NZ337031A - Process for preparation of vinyl sulfoxide compounds by using a benzyl sulfide - Google Patents

Process for preparation of vinyl sulfoxide compounds by using a benzyl sulfide

Info

Publication number
NZ337031A
NZ337031A NZ337031A NZ33703196A NZ337031A NZ 337031 A NZ337031 A NZ 337031A NZ 337031 A NZ337031 A NZ 337031A NZ 33703196 A NZ33703196 A NZ 33703196A NZ 337031 A NZ337031 A NZ 337031A
Authority
NZ
New Zealand
Prior art keywords
sulfide
preparation
benzyl sulfide
arylalkoxy
labile
Prior art date
Application number
NZ337031A
Inventor
James Abraham Aikins
Randal Scot Miller
Tony Yantao Zhang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/483,130 external-priority patent/US6372945B1/en
Priority claimed from US08/478,706 external-priority patent/US5659087A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority claimed from NZ310179A external-priority patent/NZ310179A/en
Publication of NZ337031A publication Critical patent/NZ337031A/en

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  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for preparing compounds of formula (I) wherein; R1 is hydrogen, C1-C4 alkoxy, arylalkoxy, halo or amino R2 is hydrogen, C1-C4 alkoxy, arylalkoxy, halo or amino R3 is a thermally-labile or acid-labile C4-C10 alkyl, C4-C10 alkenyl, or aryl(C1-C10 alkyl) group all having a tertiary carbon atom adjacent to the sulphur atom The process involves: 1) reacting a benzyl sulfide with a strong base to form a benzylic anion 2) condensing the benzylic anion with a benzaldehyde 3) reacting the condensation product with an acid chloride to produce an ester 4) treating the ester with a strong base to produce styryl sulfide 5) oxidizing the styryl sulfide with an oxidizing agent
NZ337031A 1995-06-07 1996-06-04 Process for preparation of vinyl sulfoxide compounds by using a benzyl sulfide NZ337031A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/483,130 US6372945B1 (en) 1995-06-07 1995-06-07 Process for the synthesis of vinyl sulfoxides
US08/478,706 US5659087A (en) 1995-06-07 1995-06-07 Diarylvinyl sulfoxides
NZ310179A NZ310179A (en) 1995-06-07 1996-06-04 Vinyl sulfoxides and a process for their synthesis

Publications (1)

Publication Number Publication Date
NZ337031A true NZ337031A (en) 2001-01-26

Family

ID=27353821

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ337031A NZ337031A (en) 1995-06-07 1996-06-04 Process for preparation of vinyl sulfoxide compounds by using a benzyl sulfide
NZ337030A NZ337030A (en) 1995-06-07 1996-06-04 Preparation of benzo[b]thiophenes from vinyl sulphoxides

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ337030A NZ337030A (en) 1995-06-07 1996-06-04 Preparation of benzo[b]thiophenes from vinyl sulphoxides

Country Status (1)

Country Link
NZ (2) NZ337031A (en)

Also Published As

Publication number Publication date
NZ337030A (en) 2000-11-24

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