NZ336245A - Identifying GDNF homologs by incubating in cells expressing c-RET receptors - Google Patents

Identifying GDNF homologs by incubating in cells expressing c-RET receptors

Info

Publication number
NZ336245A
NZ336245A NZ336245A NZ33624596A NZ336245A NZ 336245 A NZ336245 A NZ 336245A NZ 336245 A NZ336245 A NZ 336245A NZ 33624596 A NZ33624596 A NZ 33624596A NZ 336245 A NZ336245 A NZ 336245A
Authority
NZ
New Zealand
Prior art keywords
gdnf
incubating
cells
homologs
cells expressing
Prior art date
Application number
NZ336245A
Inventor
Carlos Ibanez
Urmas Arumae
Hannu Sariola
Petro Suvanto
Miles Trupp
Mart Saarma
Original Assignee
Mart Saarma
Miles Trupp
Petro Suvanto
Hannu Sariola
Carlos Ibanez
Urmas Arumae
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mart Saarma, Miles Trupp, Petro Suvanto, Hannu Sariola, Carlos Ibanez, Urmas Arumae filed Critical Mart Saarma
Priority claimed from NZ324511A external-priority patent/NZ324511A/en
Publication of NZ336245A publication Critical patent/NZ336245A/en

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A competitive assay for identifying compounds that bind to GDNF (neurotrophic factor) receptor comprising: (a) Incubating the compounds with cells that express c-RET receptors in the presence of an excess of labeled 125I-GDNF; (b) Measuring the amount of labeled GDNF bound to the cells; and (c) Comparing the amount labeled GDNF bound to the cells to that of controls not incubated with the compounds. The cells are selected from NB2/a, MN-1 or PC12 cells.
NZ336245A 1995-11-13 1996-11-13 Identifying GDNF homologs by incubating in cells expressing c-RET receptors NZ336245A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US661995P 1995-11-13 1995-11-13
US1576796P 1996-04-16 1996-04-16
US2063896P 1996-06-27 1996-06-27
US2196596P 1996-06-27 1996-06-27
US2063996P 1996-06-27 1996-06-27
NZ324511A NZ324511A (en) 1995-11-13 1996-11-13 Identification and isolation of glial cell line-derived neurotrophic factor receptors (gdnf receptors)

Publications (1)

Publication Number Publication Date
NZ336245A true NZ336245A (en) 2000-09-29

Family

ID=27555273

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ336245A NZ336245A (en) 1995-11-13 1996-11-13 Identifying GDNF homologs by incubating in cells expressing c-RET receptors

Country Status (1)

Country Link
NZ (1) NZ336245A (en)

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