NZ336245A - Identifying GDNF homologs by incubating in cells expressing c-RET receptors - Google Patents
Identifying GDNF homologs by incubating in cells expressing c-RET receptorsInfo
- Publication number
- NZ336245A NZ336245A NZ336245A NZ33624596A NZ336245A NZ 336245 A NZ336245 A NZ 336245A NZ 336245 A NZ336245 A NZ 336245A NZ 33624596 A NZ33624596 A NZ 33624596A NZ 336245 A NZ336245 A NZ 336245A
- Authority
- NZ
- New Zealand
- Prior art keywords
- gdnf
- incubating
- cells
- homologs
- cells expressing
- Prior art date
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A competitive assay for identifying compounds that bind to GDNF (neurotrophic factor) receptor comprising: (a) Incubating the compounds with cells that express c-RET receptors in the presence of an excess of labeled 125I-GDNF; (b) Measuring the amount of labeled GDNF bound to the cells; and (c) Comparing the amount labeled GDNF bound to the cells to that of controls not incubated with the compounds. The cells are selected from NB2/a, MN-1 or PC12 cells.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US661995P | 1995-11-13 | 1995-11-13 | |
US1576796P | 1996-04-16 | 1996-04-16 | |
US2063896P | 1996-06-27 | 1996-06-27 | |
US2196596P | 1996-06-27 | 1996-06-27 | |
US2063996P | 1996-06-27 | 1996-06-27 | |
NZ324511A NZ324511A (en) | 1995-11-13 | 1996-11-13 | Identification and isolation of glial cell line-derived neurotrophic factor receptors (gdnf receptors) |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ336245A true NZ336245A (en) | 2000-09-29 |
Family
ID=27555273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ336245A NZ336245A (en) | 1995-11-13 | 1996-11-13 | Identifying GDNF homologs by incubating in cells expressing c-RET receptors |
Country Status (1)
Country | Link |
---|---|
NZ (1) | NZ336245A (en) |
-
1996
- 1996-11-13 NZ NZ336245A patent/NZ336245A/en unknown
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