NZ335649A - Method of preparing amino carboxylic acids, such as N-(phosphonomethyl)glycine, via a carboxymethylation step - Google Patents
Method of preparing amino carboxylic acids, such as N-(phosphonomethyl)glycine, via a carboxymethylation stepInfo
- Publication number
- NZ335649A NZ335649A NZ335649A NZ33564998A NZ335649A NZ 335649 A NZ335649 A NZ 335649A NZ 335649 A NZ335649 A NZ 335649A NZ 33564998 A NZ33564998 A NZ 33564998A NZ 335649 A NZ335649 A NZ 335649A
- Authority
- NZ
- New Zealand
- Prior art keywords
- hydrocarbyl
- hydrogen
- carboxymethylation
- amino carboxylic
- phosphonomethyl
- Prior art date
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- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Process for the preparation of an N-acyl amino carboxylic acid by means of a carboxymethylation reaction. In this reaction, a reaction mixture is formed which contains a base pair, carbon monoxide, hydrogen and an aldehyde with the base pair comprising a carbamoyl compound and a carboxymethylation catalyst precursor. In a preferred embodiment, the carbamoyl compound and aldehyde are selected to yield an N-acyl amino carboxylic acid which is readily converted to N-(phosphonomethyl)glycine, or a salt or ester thereof. The carbamoyl compound has the general formula as seen above wherein: R1 is hydrogen, hydrocarbyl, substituted hydrocarbyl, -NR3R4, -OR5, or -SR6; R2 and R2a are independently hydrogen, hydrocarbyl, or substituted hydrocarbyl; R3 and R4 are independently hydrogen, hydrocarbyl, or substituted hydrocarbyl; R5 and R6 are independently hydrogen, hydrocarbyl, substituted hydrocarbyl, or a salt-forming cation; provided, however: (1) at least one of R2 and R2a is hydrogen, hydroxymethyl, amidomethyl, or another substituent which, under the carboxymethylation reaction conditions, is capable of producing an N-H bond, or (2) R1 is -NR3R4 and at least one of R3 and R4 is hydrogen, hydroxymethyl, amidomethyl, or another substituent, which, under the carboxymethylation reaction conditions, is capable of producing an N-H bond.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73777597A | 1997-02-13 | 1997-02-13 | |
PCT/US1998/002882 WO1998035930A1 (en) | 1997-02-13 | 1998-02-12 | Method of preparing amino carboxylic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ335649A true NZ335649A (en) | 2001-01-26 |
Family
ID=24965266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ335649A NZ335649A (en) | 1997-02-13 | 1998-02-12 | Method of preparing amino carboxylic acids, such as N-(phosphonomethyl)glycine, via a carboxymethylation step |
Country Status (1)
Country | Link |
---|---|
NZ (1) | NZ335649A (en) |
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1998
- 1998-02-12 NZ NZ335649A patent/NZ335649A/en unknown
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