NZ333030A - Compositions comprising solutes selected from raffinose, trehalose, trimethyl amine oxide and betaine, and use for the preservation of living tissues - Google Patents

Compositions comprising solutes selected from raffinose, trehalose, trimethyl amine oxide and betaine, and use for the preservation of living tissues

Info

Publication number
NZ333030A
NZ333030A NZ333030A NZ33303096A NZ333030A NZ 333030 A NZ333030 A NZ 333030A NZ 333030 A NZ333030 A NZ 333030A NZ 33303096 A NZ33303096 A NZ 33303096A NZ 333030 A NZ333030 A NZ 333030A
Authority
NZ
New Zealand
Prior art keywords
preservation
solutions
biological material
raffinose
trehalose
Prior art date
Application number
NZ333030A
Inventor
Philippa M Wiggins
Alexander B Ferguson
Original Assignee
Biostore Nz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biostore Nz Ltd filed Critical Biostore Nz Ltd
Priority claimed from PCT/NZ1996/000057 external-priority patent/WO1997047192A1/en
Publication of NZ333030A publication Critical patent/NZ333030A/en

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  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Solutions and method for preserving biological material that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of biological activity. The solutions may be either (i) substantially isotonic with the biological material to be preserved and are substantially free of univalent oxyanions and of iodide and/or (ii) comprise a first neutral solute having a molecular weight of at least about 335 and a solubility in water of at least about 0.3 M, and a second neutral solute having a molecular weight of less than about 200 and having both hydrophilic and hydrophobic moieties. The solutions preferably contain CaSO4, together with combinations of anions and cations from the protein-stabilizing ends of the Hofmeister series, such as K2SO4. The biological material may be pre-treated with sodium butyrate prior to the preservation solution.
NZ333030A 1996-06-14 1996-06-14 Compositions comprising solutes selected from raffinose, trehalose, trimethyl amine oxide and betaine, and use for the preservation of living tissues NZ333030A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/NZ1996/000057 WO1997047192A1 (en) 1996-06-14 1996-06-14 Compositions and methods for the preservation of living tissues

Publications (1)

Publication Number Publication Date
NZ333030A true NZ333030A (en) 2000-05-26

Family

ID=19916330

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ333030A NZ333030A (en) 1996-06-14 1996-06-14 Compositions comprising solutes selected from raffinose, trehalose, trimethyl amine oxide and betaine, and use for the preservation of living tissues

Country Status (3)

Country Link
JP (1) JP2000512625A (en)
DE (1) DE69625254T2 (en)
NZ (1) NZ333030A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY142987A (en) 2005-06-08 2011-02-14 Hayashibara Biochem Lab Solution for tissue adhesion prevention and method for tissue adhesion prevention
JPWO2007129618A1 (en) * 2006-05-08 2009-09-17 国立大学法人 香川大学 Neutrophil activation and migratory factor inhibitors and their use
JP5753874B2 (en) * 2010-11-09 2015-07-22 株式会社大塚製薬工場 Cell viability decline inhibitor
JP6170041B2 (en) * 2012-04-27 2017-07-26 協和メデックス株式会社 Method for stabilizing ascorbic acid in serum or plasma
WO2020122928A1 (en) * 2018-12-14 2020-06-18 National Taiwan University A stable cardioplegic solution for cardiac surgery
CN112501024A (en) * 2020-12-03 2021-03-16 英科新创（苏州）生物科技有限公司 Universal quality control product preservation solution for in-vitro diagnosis kit

Also Published As

Publication number Publication date
DE69625254T2 (en) 2003-04-17
DE69625254D1 (en) 2003-01-16
JP2000512625A (en) 2000-09-26

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