NZ332524A - 3-alkoxypyridine-2-carboxylic acid amide esters as inhibitors of collagen biosynthesis - Google Patents

3-alkoxypyridine-2-carboxylic acid amide esters as inhibitors of collagen biosynthesis

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Publication number
NZ332524A
NZ332524A NZ332524A NZ33252496A NZ332524A NZ 332524 A NZ332524 A NZ 332524A NZ 332524 A NZ332524 A NZ 332524A NZ 33252496 A NZ33252496 A NZ 33252496A NZ 332524 A NZ332524 A NZ 332524A
Authority
NZ
New Zealand
Prior art keywords
radical
alkoxypyridine
inhibitors
collagen biosynthesis
carboxylic acid
Prior art date
Application number
NZ332524A
Inventor
Klaus Weidmann
Karl Heinz Baringhaus
Georg Tschank
Martin Bickel
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Priority to NZ332524A priority Critical patent/NZ332524A/en
Priority claimed from PCT/EP1996/001793 external-priority patent/WO1997041103A1/en
Publication of NZ332524A publication Critical patent/NZ332524A/en

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Abstract

The compounds of formula I inhibit prolyl-4-hydroxylase and therefore lead to an inhibition of collagen biosynthesis. The compounds may be used in a medicament to treat fibrotic disorders of the lung, kidney, heart, eye and skin, and to treat artherosclerosis. In formula I; R1, R2 and R3 are Hydrogen, R4 is (C1-C6)-alkyl, A is CH2, in which a Hydrogen can be replaced by a methyl group, and B is CO2G, wherein G is a branched or unbranched or cyclic (C1-C20)-alkyl, a branched or unbranched or cyclic (C2-C20)-alkenyl or alkinyl radical, a corresponding (C4-C20)-alkeninyl radical, a retinyl radical, or an optionally substituted phenylalkyl radical.
NZ332524A 1996-04-30 1996-04-30 3-alkoxypyridine-2-carboxylic acid amide esters as inhibitors of collagen biosynthesis NZ332524A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ332524A NZ332524A (en) 1996-04-30 1996-04-30 3-alkoxypyridine-2-carboxylic acid amide esters as inhibitors of collagen biosynthesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP1996/001793 WO1997041103A1 (en) 1996-04-30 1996-04-30 3-alkoxypyridine-2-carboxylic acid amide esters, their preparation and their use as drugs
NZ332524A NZ332524A (en) 1996-04-30 1996-04-30 3-alkoxypyridine-2-carboxylic acid amide esters as inhibitors of collagen biosynthesis

Publications (1)

Publication Number Publication Date
NZ332524A true NZ332524A (en) 2000-09-29

Family

ID=19926988

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ332524A NZ332524A (en) 1996-04-30 1996-04-30 3-alkoxypyridine-2-carboxylic acid amide esters as inhibitors of collagen biosynthesis

Country Status (1)

Country Link
NZ (1) NZ332524A (en)

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