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Priority claimed from US08/284,391external-prioritypatent/US5851828A/en
Priority claimed from US08/394,388external-prioritypatent/US6753162B1/en
Application filed by Gen Hospital CorpfiledCriticalGen Hospital Corp
Priority claimed from NZ291017Aexternal-prioritypatent/NZ291017A/en
Publication of NZ330034ApublicationCriticalpatent/NZ330034A/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Abstract
The use and preparation of medicaments for treating HIV in a mammal by administering an effective amount of therapeutic cells, the therapeutic cells expressing a membrane-bound, proteinaceous chimeric receptor comprising: 1. an extracellular portion which includes a fragment of CD4 that is capable of specifically recognising and binding an HIV-infected cell but does not mediate HIV infection; and 2. an intracellular portion that is capable of signaling the therapeutic cell to destroy the receptor-bound HIV-infected cell.
NZ330034A1994-08-021995-07-26Method of treating HIV in mammals by administering cells bearing CD4 decoy receptors
NZ330034A
(en)
method for direction of cell response TOWARDS infection agent, cell, infected with the said agent, tumor, malignant cell or autoimmune cell (variants), cell expressing membrane-tied protein chimeric receptor (variants), DNA coding chimeric receptor, vector, a method for the treatment of infection of immunodeficiency virus (variants)