NZ304076A - cell culture methods to produce neural cells population with an introduced positive selective marker - Google Patents

cell culture methods to produce neural cells population with an introduced positive selective marker

Info

Publication number
NZ304076A
NZ304076A NZ304076A NZ30407696A NZ304076A NZ 304076 A NZ304076 A NZ 304076A NZ 304076 A NZ304076 A NZ 304076A NZ 30407696 A NZ30407696 A NZ 30407696A NZ 304076 A NZ304076 A NZ 304076A
Authority
NZ
New Zealand
Prior art keywords
cell culture
neural cells
culture methods
selective marker
selectable marker
Prior art date
Application number
NZ304076A
Inventor
Bradley Michael John Stringer
Original Assignee
Cellfactors Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellfactors Plc filed Critical Cellfactors Plc
Publication of NZ304076A publication Critical patent/NZ304076A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A graft or tissue implant comprises cells having a positive selectable marker operably linked to a tissue- or cell-specific expression element introduced therein. The cells of the implant can also comprise a negative selectable marker which can be a gene encoding products involved in programmed cell death or apoptosis such as the p53 gene. The cells can be neurones and the positive selectable marker can be neomycin phosphotransferase, hygromycin phosphotransferase, xanthineguanidine phosphoribosyl transferase or the herpes simplex virus type I thymidine kinase.
NZ304076A 1995-03-21 1996-03-20 cell culture methods to produce neural cells population with an introduced positive selective marker NZ304076A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9505663.6A GB9505663D0 (en) 1995-03-21 1995-03-21 Genetically modified neural cells
PCT/GB1996/000671 WO1996029395A1 (en) 1995-03-21 1996-03-20 Cell culture method

Publications (1)

Publication Number Publication Date
NZ304076A true NZ304076A (en) 2001-01-26

Family

ID=10771558

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ304076A NZ304076A (en) 1995-03-21 1996-03-20 cell culture methods to produce neural cells population with an introduced positive selective marker

Country Status (10)

Country Link
EP (1) EP0815206A1 (en)
JP (1) JPH11502702A (en)
KR (1) KR19980703205A (en)
AU (1) AU5116596A (en)
CA (1) CA2214385A1 (en)
CZ (1) CZ295997A3 (en)
GB (1) GB9505663D0 (en)
HU (1) HUP9802640A3 (en)
NZ (1) NZ304076A (en)
WO (1) WO1996029395A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9807935D0 (en) * 1998-04-14 1998-06-10 Univ Edinburgh Lineage specific cells and progenitor cells
US6482937B1 (en) * 1997-10-09 2002-11-19 Biotransplant, Inc. Porcine Oct-4 promoter
US6576464B2 (en) 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
DK1740945T3 (en) 2004-04-07 2019-01-21 Ncardia Ag KKE-INVASIVE, IN-VITRO FUNCTIONAL TISSUE TEST SYSTEMS
JP4814875B2 (en) 2004-05-11 2011-11-16 アキシオジェネシス エージー Assay for drug discovery based on in vitro differentiated cells
US20110223671A1 (en) * 2008-09-30 2011-09-15 Novozymes, Inc. Methods for using positively and negatively selectable genes in a filamentous fungal cell
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
JP6612227B2 (en) 2013-11-16 2019-11-27 テルモ ビーシーティー、インコーポレーテッド Cell growth in bioreactors
EP3122866B1 (en) 2014-03-25 2019-11-20 Terumo BCT, Inc. Passive replacement of media
JP6830059B2 (en) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド Scheduled cell feeding
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
JP7034949B2 (en) 2016-05-25 2022-03-14 テルモ ビーシーティー、インコーポレーテッド Cell proliferation
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN110612344B (en) 2017-03-31 2023-09-12 泰尔茂比司特公司 cell expansion
GB2619893A (en) 2021-03-23 2023-12-20 Terumo Bct Inc Cell capture and expansion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070243A (en) * 1976-08-30 1978-01-24 University Of Illinois Foundation Method for distinguishing subpopulations in a population of morphologically indistinguishable cells
CA1228025A (en) * 1983-05-20 1987-10-13 Paul I. Terasaki Method and composition for isolating white cell elements
WO1994003199A1 (en) * 1992-08-04 1994-02-17 Regeneron Pharmaceuticals, Inc. Method of enhancing differentiation and survival of neuronal precursor cells
US5514552A (en) * 1993-04-30 1996-05-07 Arch Development Corporation Hybrid neuronal cell lines compositions and methods
GB9422236D0 (en) * 1994-11-03 1994-12-21 Stringer Bradley M J Transgenic organisms and their uses
GB9422643D0 (en) * 1994-11-08 1995-01-04 Stringer Bradley M J Neural cell lines

Also Published As

Publication number Publication date
HUP9802640A3 (en) 1999-04-28
WO1996029395A1 (en) 1996-09-26
AU5116596A (en) 1996-10-08
CZ295997A3 (en) 1998-01-14
HUP9802640A2 (en) 1999-03-29
KR19980703205A (en) 1998-10-15
GB9505663D0 (en) 1995-05-10
EP0815206A1 (en) 1998-01-07
JPH11502702A (en) 1999-03-09
MX9707195A (en) 1997-11-29
CA2214385A1 (en) 1996-09-26

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