NZ287734A

NZ287734A - Preparation of n-phosphonomethylamino carboxylic acids using dialkyl phosphite

Info

Publication number: NZ287734A
Application number: NZ287734A
Authority: NZ
Inventors: Brian Kai-Ming Cheng; Jerry Rudolph Ebner; Michael Keith Stern; Dennis Patrick Riley
Original assignee: Monsanto Co
Priority date: 1994-07-01
Filing date: 1995-05-26
Publication date: 1997-12-19
Also published as: CN1109039C; DE69505534T2; DK0769014T3; PL317851A1; DE69505534D1; HU215465B; PL182347B1; HU9603604D0; JPH10502370A; AU2655795A; CA2193234A1; CN1284507A; TW340116B; CN1161042A; EP0769014A1; WO1996001266A1; HUT76816A; MY112629A; CN1061981C; ATE172465T1

Abstract

A process for preparing N-hydroxyalkylaminomethylphosphonic acid or salts thereof which comprises contacting an alkanolamine, formaldehyde and a dialkyl phosphite in the presence of an alcohol under suitable reaction conditions to produce a reaction mixture, and hydrolyzing the reaction mixture under acidic or basic conditions. In one embodiment, the N-hydroxyalkylaminomethylphosphonic acid or salts thereof is catalytically oxidized to produce an N-phosphonomethylaminocarboxylic acid or salts thereof.

Description

<div class="application article clearfix" id="description"> New Zealand Paient Spedficaiion for Paient Number £87734 New Zealand No. International No. 287734 PCT/US95/06799 TO BE ENTERED AFTER ACCEPTANCE AND PUBLICATION Priority dates: 01.07.1994;26.04.1995; Complete Specification Filed: 26.05.1995 Classification:(6) C07F9738 Publication date: 19 December 1997 Journal No.: 1423 NO DfOAKlK^QS NEW ZEALAND PATENTS ACT 1953 COMPLETE SPECIFICATION Title of Invention: Process for preparing IM-phosphonomethylamino carboxylic acids Name, address and nationality of applicant(s) as in international application form: MONSANTO COMPANY, a Delaware corporation of 800 North Lindbergh Boulevard, St Louis, MO 63167, United States of America WO 96/01266 -1- pct/ds95/06799 2877 PROCESS FOR PREPARING N-PHOSPHONOMETHYIAMINO CARBOXYLIC ACIDS 10 BACKGROUND OF THE INVENTION This invention relates to a process for preparing n-hydroxyalkylaminomethylphosphonic acid or salts thereof. In one aspect, this invention relates to a new 15 and useful process for preparing N-hydroxyalkyl- aminomethylphosphonic acid or salts thereof from an alkanolamine, formaldehyde and a dialkyl phosphite. In another aspect, this invention relates to a process for preparing N-phosphonomethylaminocarboxylie acid or salts 20 thereof by the catalytic oxidation of N-hydroxyalkylaminomethylphosphonic acid or salts thereof. In yet another aspect, this invention relates to a process for preparing N-phosphonomethylglycine useful as a herbicide. 25 N-hydroxyalkylaminomethylphosphonic acid or salts thereof are useful as a raw material in the preparation of agricultural chemicals. N-phosphonomethylaminocarboxylic acids or salts thereof are useful as agricultural chemicals. Specifically, 30 N-phosphonomethylglycine, known also by its common name glyphosate, is a highly effective and commercially important phytotoxicant useful in controlling a large variety of weeds and crops. It is applied to the foliage of a very broad spectrum of perennial and annual 35 grasses and broad-leafed plants to achieve the desired control. Industrial uses include control of weeds along WO 96/01266 PCT/US95/06799 -2- roadsides, waterways, transmission lines, in storage areas, and in other nonagricultural areas. Usually glyphosate is formulated into herbicidal compositions in the form of its various salts which retain the anionic 5 form of glyphosate in solution, preferably in water. The reaction of a primary amine with an aldehyde and a phosphite diester is disclosed in Fields, NThe Synthesis of Esters of Substituted Amino Phosphonic Acids", J. Am. Chem. Soc., Vol. 74, pp. 1528-31 (1952). 10 However, the reaction product contains considerable amounts of the undesirable bis-phosphonomethylated product. Similarly, the reaction of a primary amine with formaldehyde and phosphorous acid is disclosed in Moedritzer and Irani, "'the Direct Synthesis of 15 a-Aminomethylphosphonic Acids. Mannich-Type Reactions with Orthophosphorous Acid", J. Org. Chem., Vol. 31, pp. 1603-1607 (1966). As in Fields, the reaction product is predominantly the bis-phosphonomethylated product. 20 Barsukov et al, "Synthesis of New Complexons and Their Derivatives", Zhurnal Obshchei Khimii, Vol. 53, No. 6, pp. 1243-49 (1983) and Barsukov et al, "Synthesis of New Complexons of the Aliphatic Series and Investigation of the Mechanism of Acidic Dissociation", . 25 Zhurnal Obshchei Khimii, Vol. 55, No. 7, pp. 1594-1600 (1985) disclose the reaction of ethanolamine with paraformaldehyde and dimethyl hydrogen phosphite with a mole ratio of amine/phosphite of 1.0 and a mole ratio of formaldehyde/amine of 1.0. While these articles 30 disclose that the product is the mono- phosphonomethylated compound, reproduction of the reaction disclosed in the experimental section resulted in no mono-phosphonomethylated product being produced, i.e. 31P-NMR of the material analyzed in the Barsukov 35 example showed a 0% yield of N-(2-hydroxyethyl)aminomethylphosphonic acid 07-21(12493)A 287 73 4 -3- 10 (See Example 3 herein). The process as described in the Barsukov et al articles is, therefore, incapable of preparing N-hydroxyalkylaminomethylphosphonic acid in a commercially practicable manner. A process for preparing N-hydroxyalkyl-aminomethylphosphonic acid or salts thereof which is economical, commercially viable, and can produce essentially only the mono-phosphonomethylated product is highly desirable. SUMMARY OF THE INVENTION It is an object of the invention to provide an efficient and economical process for preparing 15 N-hydroxyalkylaminomethylphosphonic acid or salts thereof that is commercially viable; and/or to provide a process for preparing N-hydroxyalkylaminomethylphosphonic acid or salts thereof for use in the production of 20 N-phosphonomethylaminocar boxy lie acid or salts thereof1, and/or to provide an efficient and economical process for preparing N-phosphonomethylaminocarboxylic acid or salts thereof for use as agricultural chemicals, and/or 25 to provide an efficient and economical process for preparing N-phosphonomethylglycine that is commercially viable; or at least to provide the public with a useful choice. According to the invention, a process for preparing N-hydroxyalkylaminomethylphosphonic acid or 30 salts thereof is provided which comprises contacting an alkanolamine, formaldehyde and a dialkyl phosphite in the presence of an alcohol under suitable reaction conditions to produce a reaction mixture, and hydrolyzing the reaction mixture under acidic or basic 35 conditions. In one embodiment, the N-hydroxyalkylaminomethylphosphonic acid or salts N.Z. PAIL NT C 8 OCT 199/ WO 96/01266 -4- PCT/US95/06799 thereof is catalytically oxidized to produce a N-phosphonomethylaminocarboxylic acid or salts thereof. Further according to the invention, a process for preparing N-phosphonomethylglycine or salts thereof is 5 provided which comprises contacting ethanolamine, formaldehyde and a dialkyl phosphite in the presence of an alcohol under suitable reaction conditions to produce a reaction mixture, hydrolyzing the reaction mixture under acidic or basic conditions to produce 10 N-hydroxyethylaminomethylphosphonic acid or salts thereof, and catalytically oxidizing the N-hydroxyethyl-aminomethylphosphonic acid or salts thereof. 15 DETAILED DESCRIPTION OF THE INVENTION The invention relates to a process for preparing N-hydroxyalkylaminomethylphosphonic acid represented by the formula P H I HO ^ N—(-CH2")tt-OH 20 or salts thereof comprising (a) contacting an alkanolamine represented by the formula H2N-fCH2-)-nOH wherein n is 2 to 6, formaldehyde and a dialkyl phosphite in the presence of 2m alcohol represented by the formula R(0H)m, wherein R is an alkyl group having 1 25 to about 18 carbon atoms and m is 1 to 3, under suitable conditions of time and temperature to produce a reaction mixture wherein the molar ratio of alkanolamine to phosphite is 1:1 to about 8:1 and the molar ratio of formaldehyde to alkanolamine is about 0.125:1 to about WO 96/01266 5- PCT/U S95/06799 3:1, and (b) hydrolyzing the reaction mixture under acidic or basic conditions. For producing N-phosphonomethylaminocarboxylic acid represented by the formula or salts thereof, the processes of the invention further comprise (c) catalytically oxidizing the N-hydroxyalkyl-aminomethylphosphonic acid or salts thereof. 10 preparing N-phosphonomethylglycine or salts thereof comprising (a) contacting ethanolamine, formaldehyde and a dialkyl phosphite in the presence of an alcohol represented by the formula R(0H)m, wherein R is an alkyl group having l to about 18 carbon atoms and m is l to 3, 15 under suitable reaction conditions of time and temperature to produce a reaction mixture wherein the molar ratio of ethanoleunine to phosphite is about 1:1 to about 8:1 and the molar ratio of formaldehyde to alkanolamine is about 0.125:1 to about 3:1, (b) 20 hydrolyzing the reaction mixture under acidic or basic conditions to produce N-hydroxyethylaminomethyl-phosphonic acid or salts thereof, and (c) catalytically HO— 5 The invention further relates to a process for WO 96/01266 PCT/U S9S/06799 -6- oxidizing the N-hydroxyethylaminomethylphosphonic acid or salts thereof. As used herein, the tern "salts of N-hydroxyalkylaminomethylphosphonic acid" means alkali 5 netal or alkaline earth netal salts of N-hydroxyalkylaminomethylphosphonic acid and the tern " salts of N-phosphonomethylaminocarboxylic acid" neans alkali metal or alkaline earth netal salts of N-phosphonomethylaminocarboxylie acid. Thus, the 10 products of the hydrolysis and oxidation reactions can include the acid, the salts thereof or any combination thereof, depending on the specific reaction and reaction conditions selected. Alkanolamines that can be employed according to 15 the invention are represented by the formula H2N eCH2)n— OH wherein n is 2 to 6. Examples of alkanolamines include ethanolamine, 3-amino-l-propanol, 4-amino-l-butanol, 20 5-amino-l-pentanol, 6-amino- 1-hexano 1 and mixtures thereof. The currently preferred alkanolamine is ethanolamine because of ready availability and the commercial significance of the product prepared using ethanolamine as the starting material. 25 Formaldehyde can be employed according to the invention as paraformaldehyde or as an aqueous solution of formaldehyde. Aqueous formaldehyde is commercially available as 37-50 weight percent aqueous solutions which may contain methanol, ethanol, or n-butanol. 30 Dialkyl phosphites, useful in the process of the invention, are commercially available or are readily prepared by conventional methods such as by reacting WO 96/01266 PCT/CS9S/06799 -7- PC13 or P4 with an alcohol including polyols. If a polyol is used as a react aunt, the phosphite product could have a cyclic structure, i.e. a cyclic phosphite ester. See, for example, Ford-Moore et al., Org. Syn., 5 Coll. Vol. XV, p. 955 and Cook et al., J. Chea. Soc., €35 (1949) for methods utilizing PC13 and U.S. Patent No. 2,661,364 for a method utilizing P4. The alkyl groups of the dialkyl phosphites are linear or branched alkyl groups having l to 18 carbon atoms and are 10 optionally substituted with -OH groups. The preferred alkyl groups cure those that jure branched or sterically hindered, or substituted with an -OH group. Examples of suitable dialkyl phosphites include, but are not limited to, diethyl phosphite, diisopropyl 15 phosphite, di(2-butyl) phosphite, dibutyl phosphite, dimethyl phosphite, didecyl phosphite, diisooctyl phosphite, dilauryl phosphite, di(1,2-dihydroxyethane)phosphite, di(l,2-dihydroxypropane)phosphite, 20 di(l,3-dihydroxypropane)phosphite, 5,5-dimethyl-l, 3,2-dioxaphosphorinane-2-oxide, and mixtures thereof. The amount of alkanolamine utilized in the process of the invention cam be expressed as a molar ratio of alkanolamine starting material to 25 phosphite starting material. Broadly, the molar ratio of alkanolamine to phosphite is about 1:1 to about 8:1, preferably about 1:1 to about 3:1, and most preferably about 1:1 to about 1.5:1. The amount of formaldehyde utilized in the 30 process of the invention can be expressed as a molar ratio of formaldehyde starting material to alkanolamine starting material. Broadly, the molar ratio of formaldehyde to alkanolamine is about 0.125:1 to about 3:1, preferably about 0.66:1 to about 2.5:1, and most 35 preferably about 1.7:1 to about 2.3:1. WO 96/01266 -8- PCT/US95/06799 The reaction of alkanolamine, formaldehyde and phosphite is conducted at a suitable temperature which can vary over a wide range. The reaction temperature will generally be within the range of about 50°C to 5 about 150°C, preferably about 60*C to about 120°C and most preferably about 70*C to about 110eC. The reaction of alkanolamine, formaldehyde and phosphite is conducted for a suitable time which can vary over a wide range depending on various parameters, e.g. the reaction 10 temperature. Generally, the reaction time will be within the range of the time necessary for the phosphite to be consumed to about 16 hours, preferably about 2 hours to about 16 hours, and most preferably about 4 hours to about 6 hours. 15 The reaction of alkanolamine, formaldehyde and phosphite is conducted in the presence of an alcohol solvent wherein the alcohol is represented by the formula R(0H)m and R is an alkyl group having 1 to about 18 carbon atoms and m is 1 to 3. The alkyl group, R, 20 can be linear or branched and preferably is the same alkyl group as that utilized in the dialkyl phosphite starting material. Examples of suitable alcohols include, but are not limited to, methanol, ethanol, isopropanol, 25 n-butanol, 2-butanol, isooctanol, decyl alcohol, isodecyl alcohol, lauryl alcohol, ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, glycerol, 2-hydroxymethyl-2-methyl-l,3-propanediol, l,3,5-trihydroxycyclohexane and mixtures thereof. 30 The hydrolysis reaction can be conducted under acidic or basic conditions using any one of several conventional methods known to those skilled in the art. When the hydrolysis reaction is conducted under 35 acidic conditions, a preferred method is to remove the excess alkanolamine from the reaction mixture together WO 96/01266 PCT/US9S/06799 —9- with any alcohol co-solvent optionally present followed by hydrolyzing the reaction mixture in hydrochloric acid. The concentration of the hydrochloric acid is preferably in the range of 6N HC1 to 12N HC1 5 (concentrated HC1). The temperature for the acid hydrolysis reaction is generally in the range of the boiling point of the EC1 to about 250*C, preferably 80°C to 120°C. Generally, the reaction tine will be within the range of the time necessary for hydrolysis to occur 10 to about 24 hours, preferably about 2 hours to about 16 hours. After the hydrolysis reaction is completed, the N-hydroxyalkylaminonethylphosphonic acid can be recovered by amy conventional method known to those skilled in the art. 15 When the hydrolysis reaction is conducted under basic conditions, a preferred method is to contact the reaction mixture with an alkali netal hydroxide or alkaline earth netal hydroxide, preferably an alkali netal hydroxide. The concentration of the alkali netal 20 hydroxide or alkaline earth netal hydroxide is broadly within the range of about 15 weight percent to about 90 weight percent, preferably about 40 weight percent to about 60 weight percent, and nost preferably about 50 weight percent. The anount of alkali metal hydroxide 25 or alkaline earth netal hydroxide utilized in the hydrolysis reaction can be expressed as the ratio of equivalents of hydroxide to noles of phosphite starting material. Broadly, the ratio is about 2:1 to about 5:1, preferably about 2.5:1 to about 4:1, and most preferably 30 about 3:1. In the preferred embodiment of the hydrolysis conducted under basic conditions, the alcohol formed during the hydrolysis, i.e. the alcohol corresponding to the alkyl groups in the dialkyl phosphite, is removed 35 from the reaction mixture during hydrolysis, such as by distillation. For example, when diisopropyl phosphite WO 96/01266 PCT/US95/06799 is utilized in the process isopropyl alcohol is removed during the hydrolysis. The alkali metal hydroxides for use in the process of the invention include lithium hydroxide, 5 sodium hydroxide, potassium hydroxide, rubidium hydroxide and cesium hydroxide. Because of their ready availability and ease of handling, sodium hydroxide and potassium hydroxide are preferred, and sodium hydroxide is especially preferred. 10 The alkaline earth metal hydroxides for use in the process of the invention include beryllium hydroxide, magnesium hydroxide, calcium hydroxide, strontium hydroxide and barium hydroxide. Calcium hydroxide is currently preferred because of its ready 15 availability. The temperature for the base hydrolysis reaction is generally in the range of about 80°C to about 250°c, preferably about 80°C to about 180°C, most preferably about 120°C to about 150°C. Generally, the reaction 20 time will be within the range of the time necessary for hydrolysis to occur to about 48 hours, preferably about 2 hours to about 24 hours and most preferably about 2 hours to about 16 hours. After the hydrolysis reaction is completed, the N-hydroxyalkylaminomethylphosphonic 25 acid or salts thereof can be recovered by any conventional method known to those skilled in the art. The oxidation of the N-hydroxyalkylaminomethyl-phosphonic acid or salts thereof is conducted in the presence of a catalyst. Suitable oxidation catalysts 30 are well known to those skilled in the art such as Raney copper and those described in U.S. 4,810,426 and U.S. 5,292,936, which are both incorporated by reference herein. In U.S. 4,810,426, the oxidation of 35 N-(2-hydroxyethyl)aminomethylphosphonic acid is conducted with an alkali metal hydroxide in the presence of water and a WO 96/01266 PCT/US95/06799 -11- suitable catalyst select from cadmium, zinc, copper, palladium and platinum and their respective oxides, hydroxides and salts. The oxidation reaction is conducted at a temperature of 200eC to 300°C. 5 In U.S. 5,292,936, the oxidation of N- (2-hydroxyethyl) aminomethylphosphonic acid is conducted with an alkali metal hydroxide in the presence of em effective eunount of a Raney copper catalyst containing from about 50 peurts per million to about 10 10,000 parts per million of an element selected from the group consisting of chromium, titanium, niobium, tantalum, zirconium, vanadium, molybdenum, manganese, tungsten, cobalt, nickel and mixtures thereof. Of the above elements, chromium, molybdenum, and mixtures of 15 chromium and molybdenum are preferred. The oxidation reaction is conducted at a temperature between about 120#C and 220°C. Another particularly applicable type of oxidation catalysts are the supported mixed metal catalysts such 20 as those in U.S. Application Serial No. 08/269,722, and its subsequent continuation-in-part U.S. Application Serial No. 08/407,723, which are incorporated by reference herein. The supported mixed metal catalyst of the present invention is prepared by depositing from 25 about 1 wt.% to about 50 wt.%, based on the total weight of the catalyst, of an element selected from the group consisting of copper, cobalt, nickel, cadmium and mixtures thereof on a hydroxide resistant support having from about 0.05 wt.% to about 10 wt.% of an anchor metal 30 selected from the group consisting of platinum, palladium, ruthenium, silver, gold and mixtures thereof. Suitable hydroxide resistant supports include titanium oxide, zirconium oxide and carbon. Carbon is preferred. Activated carbon is even more preferred. 35 The particulate anchor metal deposited on the hydroxide resistant support can be a noble metal. By WO 96/01266 PCT/DS95/06799 -12- noble metal is meant gold, silver, platinum, palladium ruthenium or mixtures thereof. Platinum or palladium are preferred. Platinum is most preferred. The amount of anchor metal to be deposited on the hydroxide 5 resistant support can vary from about 0.05 wt.% to about 10 wt.%, based on the total weight of the catalyst. When less than about 0.05 wt.% anchor metal is deposited on the hydroxide resistant support, there is insufficient anchor metal to combine with the copper, 10 cobalt, nickel, and/or cadmium to provide a satisfactory catalyst. On the other hand, when more than about 10 wt.% anchor metal, based on the total weight of the catalyst, is deposited, on the support, the crystallite size of plated metal tends to increase. Larger crystal 15 sizes of the plated elemental metal sometimes leads to reduced catalytic performance. It is preferred to use from about 0.1 wt.% and about 5 wt.%, based on the total weight of the catalyst, of the anchor metal. The currently preferred supported mixed metal catalyst is a 20 carbon supported mixture of copper and platinum or palladium. Suitable hydroxide resistart supports containing a suitable anchor metal can be obtained commercially. The amount of deposited metal (i.e., copper, 25 cobalt, nickel and/or cadmium) should be sufficient to cover at least some of the embedded anchor metal particles. In addition to the coated particles the presence of at least some particles of the plating metal embedded on the support but not adherent on the anchor 30 metal can exist. X-ray Photoelectron Spectroscopy (XPS) is a technique which can be used to measure the relative concentration of surface atoms in the catalyst. Using this technique, it has been found that preferably in the catalysts of this invention the surface atomic ratio of 35 the deposited metal to the anchor metal is greater than 2.0, and more preferably, the XPS surface atomic ratio WO 96/01266 PCT/US95/06799 -13- is greater than the corresponding bulk atomic ratio. Any number of techniques can be used to deposit the anchor metal on the alkali resistant substrate and to deposit the copper, cobalt, nickel, and/or cadmium 5 onto the anchor metal. It is preferred, however, to use electroless metal deposition. Electroless metal deposition refers to the chemical deposition of an adherent metal coating on a suitable substrate in the absence of an externally applied electric source. 10 Regardless by the method of depositing the anchor metal onto the substrate, the size of the metal particles is a critical parameter in that it dictates the size of the crystals of copper, cobalt, nickel and cadmium to be deposited. The crystallite size of the 15 copper, cobalt, nickel, and cadmium should be less than about 500 Angstroms, and in the case of copper, it is preferred that the crystallite size is less than about 300 Angstroms. Although applicants do not wish to be bound by any particular theory, it is believed that a 20 uniform distribution of the anchor metal is best for achieving high reaction yields, but not necessary fast reaction rates. Further, it is believed that it is important to have small, well-reduced, highly-dispersed anchor metal particles. 25 In practice, the substrate containing the anchor metal is added to and slurried in water. Next, a plating solution, e.g., copper plating solution, is prepared by mixing the plating solution in the appropriate proportions while the slurry of substrate 30 and water Ar- gently stirred at a temperature of about 0°c up to i0°C or higher in an open container. The plating solution containing a complexing agent and a reducing agent is added to the slurry in small increments by monitoring the pH with each addition. 35 After an appropriate time interval, the next increment of the slurry is slowly added. The amount of plating WO 96/01266 PCT/US95/06799 -14- solution added depends on the desired weight percent catalytic metal on the anchor metal in the catalyst. When the deposition of catalytic metal is completed, an essentially colorless filtrate results. 5 Next, the finished catalyst is filtered and washed with distilled water. The filtration must be done in an inert atmosphere, such as a nitrogen atmosphere, to avoid exposure of the catalyst to air. Washing the catalyst removes unreacted components such 10 as parts per million impurities and unreacted reducing agent, such as formaldehyde. It has been found that from about 0.5 to 1.5 wt. % alkali metal is left on the catalyst, which is usually not harmful. The catalyst should be stored in a manner which avoids exposure to 15 oxygen, preferably by being kept under water. The currently preferred oxidation catalysts for use in the process of the invention are the catalysts of U.S. 5,292,936 and the supported mixed metal catalysts, with the supported mixed metal catalysts being 20 especially preferred. The reactions of the present invention can be conducted under atmospheric pressure or in a closed reaction vessel under a pressure. When the reactions are conducted in a pressure vessel, the pressure will 25 generally be the vapor pressure of the reaction mixture at the reaction conditions. 30 General Procedures; Dialkyl phosphites were purchased from Aldrich Chemical when available. Phosphites which were not. commercially available were synthesized from PC13 and the corresponding alcohol by the method of Ford-Moore et. al Org. Syn. Coll. Vol. IV 35 p. 955 or the method of Cook et. al. J. Chem. Soc. 635, (1949) . Formaldehyde was purchased from Aldrich WO 96/01266 PCT/US95/06799 -15- Chemical as a 37% solution in water. Paraformaldehyde (91-93%)was obtained from Hoechst Celanese Corporation. The yield of N-hydroxyalkylaminomethylphosphonic acids or their salts were determined by 31P-NMR in D20 using 5 methylenediphosphonic acid as an internal standard. Typically NMR samples were prepared in D20 containing conc. HC1 such that a sample pH»0.7 was obtained. NMR spectra were obtained on Varian VXR-300 or Varian VXR-4 00 spectrometers. Qualitative and quantitative mass 10 spectra were run on a Finnigan MAT90, a Finnigan 4500 and a VG40-250T spectrometers. Example 1 15 This comparative example illustrates the use of various dialkylphosphites in the synthesis of N-(2-hydroxyethyl)aminomethylphosphonic acid conducted without an alcohol being present. Diisopropylphosphite (17 g, 0.1 mmol), 20 paraformaldehyde (3.6 g, 0.12 mmol) and ethanolamine (48.8 g, 0.8 mmol) was charged into a round bottom flask equipped with magnetic stir bar and reflux condenser. The reaction was heated to 100°C for 16 h. Base hydrolysis of the intermediate esters was achieved by 25 adding 2 equiv. of NaOH (16 g of a 50% solution) and heating to 120°C for 16 hours. The reaction was allowed to cool and was concentrated under vacuum. Water (30 mL) was added to the reaction mixture and a sample was removed for 31P-NMR analysis. Yield of 30 N-(2-hydroxyethyl)aminomethylphosphonic acid (13%) was based on moles of phosphite charged. Summarized in Table l are the results of reactions run with a similar experimental protocol as described above but with different dialkylphosphites and various 35 ratios of reagents. WO 96/01266 PCT/US95/06799 -16- table 1 Preparation of N-2-Hydracye thyUininoroethytphcuphon ir Acid Using • Variety of Dialkylpbocphitet 5 Jdafe Phosphite ffttumolaminc Formaldehyde* Reaction Temp *C Hydrolysis Method % Yield6 1C Dimethyl 0.1 0.8 0.12 (p) 80 base 20 Diethyl 0.1 0.8 0.1 <p) 70 acid 18s Diisopropyl 15 0.1 Di-tec-butvl 0.8 0.12 (p) 100 base 13 0.1 0.8 0.12 <j») 100 base 15 * Formaldehyde was charged as a 37% solution in water, (p) denotes when panfonnaldehyde was used. 20 b Yields determined by 31P-NMR and are based on moles of phosphite charged' Reactions were run for 6 hours. Example 2 25 This example illustrates the advantage of using an alcohol as solvent in the preparation of N-(2-hydroxyethyl)aminomethylphosphonic acid from dialkylphosphites. 30 A solution of paraformaldehyde (4.0 g, 0.13 mol), ethanolamine (6 mL, 0.097 mol), diisopropylphosphite (17 g, 0.1 mol) and 50 ml of isopropanol was stirred at 120°C for 16 hours. The solution was concentrated to dryneiss and 17 ml of 50% NaOH was added. The solution 35 was heated at reflux for 16 h, cooled to room temperature and concentrated under vacuum. Water (100 mL) was added to homogenize the mixture. The reaction was analyzed by 31P NMR in D20 at pH= 0.8. N- (2-Hydroxylethyl) aminomethylphosphonic acid was 40 obtained in 33% yield. WO 96/01266 PCT/US95/06799 -17-Bxample 3 This is a comparative example which illustrates the procedure reported by Barsukov et al, "Synthesis of New 5 complexons and Their Derivatives'*, Zhurnal Obshchei Khimii, Vol. 53, No. 6, pp 12243-49 (1983) for the preparation of N-(2-hydroxyethyl)aminomethylphosphonic acid utilizing dimethylphosphite. Dimethylphosphite (36g, 0.3227 mole) was added io dropwise over a period of l hour to a stirring solution of paraformaldehyde (9.8 g, 0.32 mole) and ethanolamine (20 g, 0.32 mole) below 20°C under nitrogen. The solution was heated to. 80°C for 1 hour and then cooled to room temperature. The solution was extracted with 15 350 ml of benzene as described in the paper. The benzene solution was then passed through a column containing 1 kg of alumina and the column was eluted with 1 liter of benzene. The benzene solution was concentrated under vacuum to dryness and 250 mL of Cone. 20 HC1 was added. The solution was heated to 110°C for 6 hours. Analysis of the reaction mixture by 31P-NMR showed o* yield of N-(2-hydroxyathyl)-aminomethylphosphonic acid. This Example demonstrates that contrary to what is disclosed in the Barsukov et al 25 reference, the process taught in the Barsukov et al reference produces no N-(2-hydroxyethyl)-aminomethylphosphonic acid. IBHfflPl* 4 30 This example illustrates the use of the Raney copper catalyst containing chromium of U.S. 5,292,936 to convert N-(2-hydroxyethyl)aminomethylphosphonic acid to N-phosphonomethylglycine. 35 WO 96/01266 PCT/US95/06799 -18- Into a 160 ml nickel autoclave equipped with a stirrer is charged N-2-(hydroxyethyl)aminomethylphosphonic acid (16.84 g, o.n mol.) vater (11.3 al) and 45 weight % potassium 5 hydroxide (48.7 g, 0.39 mol.) and Raney copper catalyst containing 943 parts per million chromium (3.53 g). The autoclave is sealed and heated to 160°c. under a pressure of 9.5 Kg/cm2 while stirring the liquid phase in the autoclave. After 1.85 hours, hydrogen evolution 10 ceases. The yield of N-phosphonomethylglycine as its potassium salt is 98.5%. Example S 15 This example illustrates the preparation of the supported mixed metal catalyst of the present invention. Into a one-liter glass beaker containing a teflon coated, 5 centimeter long, magnetic stirring bar, on a magnetic stirring plate are added distilled water 20 (169 ml) and wet 5% platinum on activated carbon in powder form, available from Degussa Corporation of Ridgefield Park, NY, which corresponds to 13.37 grams on a dry weight basis. In a separate one-liter beaker a copper plating solution is prepared by adding the 25 following components, most of which are available from MacDermid, Inc. of Waterbury, CT, with stirring in the following order: (1) 687 ml deionized water (2) 90 ml MACuPlex Ultra Dep 1000B* 30 (3) 54 ml MACuPlex Ultra Dep 1000A* (4) 18 ml MACuPlex Ultra Dep 1000D* (5) 5 ml 37% w/w formaldehyde 35 * proprietary products of MacDermid TOTAL VOLUME 854 ml WO 96/01266 PCT/US95/06799 -19- According to MacDermid's product description for Product Code No. 17970, the resulting aqueous solution comprises the following active ingredients: 5 Copper sulfate 4.0 g/1 Formaldehyde 6.0 g/1 Sodium hydroxide 9.0 g/1 Excess EDTA chelant 0.06 molar 10 The resulting plating solution is filtered and then added to the slurry of the 5% platinum on activated carbon by adding 122 milliliter increments every 3 minutes at 40°C. The pH is monitored to verify the extent of the reaction. Time between additions is 15 extended when gas evolution becomes too vigorous. After the addition of the plating solution is completed, the catalyst is recovered by filtration using a 4 liter vacuum flask, a 350 ml coarse glass filter funnel, and a glass dome over the top of the funnel with 20 nitrogen. After filtration, the solid material is washed with three to four 250 milliliter portions of deionized water. The dry weight yield in this preparation is 18.4 grams. Microanalysis of the catalyst shows the elemental composition to be 13.4 wt.% 25 copper and 3.4 wt.% platinum, based on the total weight of the catalyst. The average copper crystal size as determined by XRD line broadening is found to be 157 Angstroms. 30 This example shows another preparation of the supported mixed metal catalyst of the present invention. To a 2-liter glass beaker containing a Teflon polymer coated, 2.5 centimeter long, magnetic stirring 35 bar on a magnetic stir plate is added distilled water (190 ml) followed by 5 wt.% platinum on activated WO 96/01266 PCT/US95/06799 -20- carbon, available from Degassa Corporation, corresponding to 16.42 grains (dry weight). An aqueous copper plating solution is prepared in a 4 liter beaker by adding the following components with stirring. 5 (1) 500 ml DI water (2) NaKC4H406«4 H20 (tartrate) [29.99 g, 0.106 moles]; stir to dissolve (3) In a separate beaker, dissolve 11.79 gms of 10 cuS04*5 H20 (3 gms Cuf) (0.047 mo.'es) in 400 ml deionized water (4) Add copper solution (3) to the resulting tartrate solution (2) (5) Add 13.60 grams of 50 wt% NaOH [0.17 mole] 15 (6) 11.35 ml 37 wt.% formaldehyde [0.15 mole] TOTAL VOLUME 1125 ml The resulting plating solution is added to the 20 slurry of 5 wt. % platinum on carbon in a total of about twelve, 79 ml increments with one increment every 2.5 minutes. The pH is monitored to verify the extent of the reaction and to delay incremental addition in time if and when the solution degassing becomes too vigorous. 25 The catalyst, after the plating solution is added to the slurry, is recovered by filtration as in Example 9. The dry weight yield is 20.03 grams. The composition is analyzed and is found to be 14.5% copper and 3.8% platinum, based on the total weight of the catalyst. 30 The average copper crystal dimension is 119 Angstroms. Example 7 This comparative example illustrates the 35 production of N-(2-hydroxyethyl)aminomethylphosphonic acid using diisopropylphosphite in the absence of WO 96/01266 PCT/US95/06799 -21- alcohol as solvent. A solution of 37% aqueous formaldehyde (8.2 g, 0.1 mole) and ethanolamine (9 g, 0.15 mole) was stirred at room temperature between one and two hours followed by 5 the addition of diisopropylphosphite (17 g, o.l mole). The reaction solution was heated at 80*C for 3 hours. Water (50 mL) and 16 mL of 50% NaOH was added to the reaction and the mixture was distilled in a Dean-Stark apparatus for 3 hours at 150°C to hydrolyze the 10 intermediate esters with the simultaneous removal of water, isopropanol and ethanolamine (80-100 mL total volume removed). A white precipitate formed which was dissolved with an additional 50 mL of water. Analysis of the reaction mixture by 31P-NMR showed a 49% yield of 15 N-(2-hydroxyethyl)aminomethylphosphonic acid and 6% yield of bis-N-(2-hydroxyethyl)aminomethylphosphonic acid. Example 8 20 This comparative example illustrates the production of N-(2-hydroxyethyl)aminomethylphosphonic acid when the amount of formaldehyde is varied and the reaction is conducted with a dialkyl phosphite in the absence of 25 alcohol as solvent. The reaction conditions employed are the same as those described in Example 7 except that the amount of formaldehyde used was varied between 1 and 2 equivalents based on phosphite. The results of these experiments 30 are summarized in Table 2. 35 WO 96/01266 -22 PCT/US95/06799 TABLE 2 Prcpvmtioa of N-HydregyethyUminotneUiyiphotpltook: Add Using Diitopropyiphotphlle 5 _ Mole % YleM Fhtxphhc Bthanolamfae FbrtMldehycJc1 Temp *C Mono* Bis*1 10 0.1 0.1 15 ai 0.1 0.1 20 * N-(2-hyiJroxyethyl)«rainomethylpho«phofik: add. bbU-N(-2-hydroxyethyl)amlriocnethy1pho«phonk add. BXftffPUt 9 25 This example illustrate the effect of varying the amount of formaldehyde employed in the reaction when a dialkyl phosphite is used in the presence of an alcohol solvent. 30 In a typical reaction 37% formaldehyde (17 g, 0.2 mole) was added to a mixture of ethanolamine (6.1 g, 0.1 mole) in 100 mL of methanol. The mixture was heated to 70°C and dimethylphosphite (11 g, 0.1 mole) was added in one portion. The reaction was stirred at 70°C for 35 several hours. Concentrated HC1 was added (50 mL) and the reaction was heated at 120 °C for 2 hours to hydrolyze the intermediate esters. Analysis of the reaction mixture by 31P-NMR showed a 74% yield of 0.15 0.10 80 49 6 0.15 0.12 80 37 3 0.1S 0.16 80 47 6 0.15 0.18 80 48 10 0.15 020 80 38 11 </div>

Claims

1. WO 96/01266 PCT/US95/06799 N-(2-hydroxyethy1)aminomethylphosphonic acid. The results of identical reactions conducted with varying amounts of formaldehyde are shown in Table 3. 5 TftBftE 3 Preparation of N-HydroxycthyUnuno«nelhylphoiphooic Add Usinf Dhnethyiphosphile In Methanol Solvent with Vatyinj Amounts of Formaldehyde 10 jtssti N-{2-hydro*yethyl)amhK>-Pbocphitc Ethanolamine Formaldehyde Temp *C metbytpboaphoaic add 15 o.i 0.10 .0.10 to ao 0.1 0.10 0.17 70 X 20 0.1 aio OJO 70 74 Example 10 25 This example illustrates the production of N-hydroxyethylaminomethylphosphonic acid utilizing the cyclic dialkyl phosphite 5,5-dimethyl-l,3,2-dioxaphosphorinane-2-oxide. A mixture of p-formaldehyde (6.6 g, 0.22 mole), 30 ethanolamine(6.1 g, 0.1 mole) and methanol (100 mL) were stirred at 80°C for 4 hours under nitrogen. 5,5-dimethyl-l,3,2—dioxaphosphorinane-2-oxide (15 g, 0.1 mole) was added in one portion to the mixture. The reaction was stirred at 80°C for several hours. 35 Concentrated HC1 was added (50 mL) and the mixture was refluxed for 16 hours. Analysis of the reaction by 31P-NMR showed 59% yield of N-hydroxyethylaminomethylphosphonic acid. WO 96/01266 PCT/US9S/06799 ?877 3 -24- THAT WHICH 18 CTiRTMKT) IS:

l. A process for preparing N-hydroxyalkyl-aminomethylphosphonic acid represented by the formula 5 10 or salts thereof comprising: (a) contacting an alkanolamine represented by the formula wherein n is 2 to 6, formaldehyde and a dialkyl phosphite in the presence of an alcohol under suitable 20 conditions of time and temperature to produce a reaction mixture wherein the molar ratio of alkanolamine to phosphite is about 1:1 to about 8:1 and the molar ratio of formaldehyde to alkanolamine is about 0.125:1 to about 3:1, and 25 (b) hydrolyzing said reaction mixture under acidic or basic conditions.
2. The process of Claim 1 wherein said alcohol is represented by the formula R(0H)n wherein R is an alkyl group having 1 to about 18 carbon atoms and n is l to 3. 30
3. The process of Claim 1 wherein the molar ratio of formaldehyde to alkanolamine is about 0.66:1 to about 2.5:1.
4. The process of Claim 3 wherein the molar ratio of formaldehyde to alkanolamine is about 1.7:1 to about 35 2.3:1. 15 H2N (CH2 )n—OH
5. The process of Claim 1 wherein the molar ratio wo 96/01266 25 pct/cs95/06799 287734 of alkanolamine to phosphite is about 1:1 to about 3:1.
6. The process of Claim 1 wherein said phosphite is dimethyl phosphite.
7. The process of Claim 1 wherein the hydrolysis 5 is conducted under basic conditions.
8. The process of Claim 7 wherein said hydrolysis is conducted in the presence of an alkali metal hydroxide or alkaline earth metal hydroxide.
9. The process of Claim 7 wherein alcohol formed 10 during said hydrolysis is removed during said hydrolysis.
10. The process of Claim 1 wherein n is 2.
11. The process of Claim 1 further comprising: (c) catalytically oxidizing said 15 N-hydroxyalkyl-aminomethylphosphonic acid or salts thereof to produce an N-phosphonomethylaminocarboxylic acid represented by the formula 20 OH O 0 _ i II HO P^^N-tCH2lSTC— OH H<!> 25 or salts thereof. 30
12. The process of Claim 11 wherein the oxidation is conducted by contacting said N-hydroxyalkyl-aminomethylphosphonic acid or salts thereof with an alkali metal hydroxide in the presence of an effective eunount of a Raney copper catalyst containing from about 35 50 to about 10,000 parts per million of an element selected from the group consisting of chromium, 0 7- 21 ( 12-1 9 J ) A 287734 titanium, niobium, tantalum, zirconium, vanadium, molybdenum, manganese, tungsten, cobalt, nickel and mixtures thereof.
13. The process of Claim 11 wherein the oxidation 5 is conducted in the presence of an effective amount of a carbon supported mixed metal catalyst.
14. The process of Claim 13 wherein said catalyst is a carbon supported mixture of Cu and Pt or Pd.
15. The process of Claim 1 wherein said temperature • • 10 of the reaction of (a) is about 50 C to about 150 C.
16. A process for preparing N-phosphonomethylglycine or salts thereof comprising: (a) contacting ethanolamine, formaldehyde and a dialkyl phosphite in the presence of an alcohol under 15 suitable reaction conditions of time and temperature to produce a reaction mixture wherein the molar ratio of ethanolamine to phosphite is about 1:1 to about 8:1 and the molar ratio of formaldehyde to ethanolamine is about 0.125:1 to about 3:1, 20 (b) hydrolyzing said reaction mixture under acidic or basic conditions to produce N-hydroxyethyl-aminomethylphosphonic acid or salts thereof, and (c) catalytically oxidizing said N-hydroxyethyl-aminomethylphosphonic acid or salts thereof. 25
17. The process of Claim 16 wherein the oxidation is conducted by contacting said N-hydroxyalkyl-aminomethylphosphonic acid or salts thereof with an alkali metal hydroxide in the presence of an effective amount of a Raney copper catalyst containing from about 30 50 to about 10,000 parts per million of an element selected from the group consisting of chromium, titanium, niobium, tantalum, zirconium, vanadium, molybdenum, manganese, tungsten, cobalt, nickel and mixtures thereof. ^ 35
18. The process of Claim 16 wherein the oxidation - is conducted in the presence of an effective amount of a 07-21(12493)A -27- 287 73 k carbon supported mixed metal catalyst.
19. The process of Claim 16 wherein the hydrolysis is conducted under basic conditions.
20. The process of Claim 16 wherein the hydrolysis 5 is conducted in the presence of an alkali metal hydroxide or alkaline earth metal hydroxide.
21. The process of Claim 19 wherein alcohol formed during said hydrolysis is removed during said hydrolysis. 10
22. The process of Claim 16 wherein said alcohol is represented by the formula R(0H)m wherein R is an alkyl group having 1 to about 18 carbon atoms and m is 1 to 3.
23. The process of Claim 16 wherein the molar ratio 15 of ethanolamine to phosphite is about 1:1 to about 3:1.
24. The process of Claim 16 wherein the molar ratio of formaldehyde to ethanolamine is about 0.66:1 to about 2.5:1.
25. The process of Claim 24 wherein the molar ratio 20 of formaldehyde to ethanolamine is about 1.7:1 to about 2.3:1.
26. The process of Claim 16 wherein said phosphite is dimethyl phosphite.
27. A process for preparing N-hydroxyalkyl-aminomethyl-phosphonic acid of the formula defined in claim 1 or salts thereof substantially as herein described with reference to any example thereof.
28. A process for preparing N-phosphonomethylglycine or salts thereof substantially as herein described with reference to any example thereof. END OF CLAIMS N ~Z PATENT Q1 ' ■' ^ S 8 OCT tW i i R£0c(V t-t-/