NZ250737A - Powdered suspension of acetaminophen with one or more antacid agents - Google Patents
Powdered suspension of acetaminophen with one or more antacid agentsInfo
- Publication number
- NZ250737A NZ250737A NZ250737A NZ25073794A NZ250737A NZ 250737 A NZ250737 A NZ 250737A NZ 250737 A NZ250737 A NZ 250737A NZ 25073794 A NZ25073794 A NZ 25073794A NZ 250737 A NZ250737 A NZ 250737A
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- NZ
- New Zealand
- Prior art keywords
- therapeutic composition
- weight
- parts
- composition
- suspension
- Prior art date
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
New Zealand Paient Spedficaiion for Paient Number £50737
250737
Priority Date(s):
Owmpifcte Specification Filed:
RwucaN^,. IW.;. AM ¥33A.c*v»fva.
Publication Date: .???!
P.O. Journal. No: .
WO DRAWimS
PATENTS FORM NO. 5
Our Refs DT202629
NEW ZEALAND
PATENTS ACT 1953 COMPLETE SPECIFICATION
THERAPEUTIC CQMPOSITIOH AND METHOD OF USING SAME FOR TREATMENT OF HANGOVER
We, BARHETT LABORATORIES LIMITED, a caapany wwftor the laws of the State of Louisiana, U.S.A of 3302 Mercer, Houston, Texas 77027, United States of America hereby declare the invention, for which we pray that a patent may be granted to us and the method by which it is to be performed, to be particularly described in and by the following statement:
PT0583964
(followed by page la)
THERAPEUTIC COMPOSITION AND METHOD OF USING SAME FOR TREATMENT OF HANGOVE:
250737
Background of the Invention
Field of the Invention
The present invention relates to therapeutic compositions, particularly non-prescription compositions and methods of administering same for treatment of hangover as a result of overindulgence in alcohol.
Description of the Prior Art
The major symptoms of the condition generally known as "hangover" resulting from overindulgence in alcohol, include headache, acid indigestion, queasiness or nausea, diarrhea, lethargy and a general malaise. These symptoms have been treated by various techniques, generally aimed at relief of only one or a few of the symptoms. At least one formulation, designed for relief of all of the symptoms, is disclosed in U.S. Patent No. 3,829,569. However, that formulation must be administered in two separate portions. This is because the ingredients are such that the necessary quantities thereof required to produce the desired therapeutic results are too large to permit administration in a single dose. Furthermore, the ingredients are such that, if admixed in a single-portion dose, they interact in such a way as to adversely affect the stability of the formulation. Also, the formulation is administered in capsule form and, therefore, must normally be taken with water or some other fluid to facilitate swallowing.
It is a general object of the present invention to provide an improved therapeutic composition for the treatment of hangover, which lessens or avoids the disadvantages of prior formulations or at least provides '
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* 3
the public with a useful alternative.
Summary of the Invention la
(followed by page 2)
250737
An important'feature of the invention is the provision of a therapeutic composition for simultaneous treatment of all of the symptoms of hangover, and which can be administered in liquid form.
Another feature of the invention is the provision of a therapeutic composition of the type set forth, which may be taken in a single-portion dose and is characterized by stability and long shelf life.
In connection with the foregoing feature, it is another feature of the invention to provide a therapeutic composition of the type set forth, which includes acetaminophen along with antacid agents in a form to optimize effectiveness while not adversely affecting the acetaminophen.
Still another feature of the invention is the provision of a method for oral administration of a therapeutic composition of the type set forth.
Certain of these and other features of the invention are attained by providing a therapeutic composition for oral administration comprising, in suspension in a non-toxic therapeutically acceptable suspension medium, a finely powdered form of each of
(a) a pain relieving amount of acetaminophen, and
(b) an acid neutralizing and stomach settling amount of one or more mild antacid agents,
such that the composition is basic and has a pH less than 9.
The invention consists of these and other novel features hereinafter fully described, and particularly pointed out in the appended claims, it being understood that various changes in the details may be made without departing from the spirit, or sacrificing any of the advantages of the present invention. -• ^
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Description of the Preferred Embodim
The composition of the present invention includes four principal active ingredients: (1) an analgesic; (2) an antacid; (3) a stimulant; and (4) a rapidly available energy source. Aspirin and acetaminophen are both effective analgesics. Aspirin functions as an anti-inflanunatory agent as well as an analgesic, but its anti-inflammatory properties are not needed in the treatment of hangover. Furthermore, aspirin has the disadvantages of exacerbating acid indigestion, which is one of the hangover symptoms to be treated, as well as irritating the stomach lining and potentially causing gastro-intestinal bleeding. Accordingly, in the present invention acetaminophen is used as the sole analgesic.
Heretofore, it has been thought that acid indigestion was one of the principal manifestations of hangover. Consequently, formulations for treating hangover have typically contained a strong antacid agent, such as magnesium hydroxide. This has resulted in very high pH formulations, which tend to degrade acetaminophen, resulting in unacceptably short shelf life of compositions which include acetaminophen. One solution to this problem was separation of the acetaminophen and the strong antacid into separate capsules, and is disclosed in the aforementioned U.S. patent no. 3,829,569. But that solution is attended by more complicated and expensive manufacture and inconvenient usage.
Applicants have determined that acid indigestion is not as significant a symptom of overindulgence in alcohol as had
*250737
250737
queasiness and occasional diarrhea. Thus, a significant aspect of the present invention is the provision of a hangover treatment composition in which the selection, proportions, particle size and physical characteristics of the antacid agents is such as to provide sufficient acid neutralizing capacity to be effective in treating minor conditions of acid indigestion or mild stomach acidity, and also provide marked improvement in treating queasiness and diarrhea* This has made it possible to significantly reduce the pH of the composition vhile permitting it to be provided in a suspension forn which accelerates and enhances the therapeutic action o£ the ingredients.
A composition effective in treating all of the major 0 hangover symptoms requires, in addition to analgesic and antacid agents, active ingredients which provide other therapeutic effects. These ingredients include a stimulant to induce alertness, a quickly available carbohydrate to provide a source of energy, and a stomach protectant or adsorbent. There oust also be provided a suitable suspension medium and it is also desirable that the composition be pleasant tasting.
A formulation vhich provides the foregoing effects and which has been found to produce excellent results in relieving the symptoms of overindulgence in alcohol is set forth in the following Example:
Substance
Example I
Function
250737
Amount in Parts By Weight ± 10%
Acetaminophen Magnesium trisilicate
Calcium citrate, pulverized to a fine powder Calcium carbonate, light precipitated powder Caffeine, anhydrous Methylparaben Propylparaben Dextrose
Glycerin
Xanthan gum
Spearmint oil Caramel
Purified water
Analgesic 8.0
Antacid, stomach 6 protectant, adsorbent
Antacid, calcium 10 source
Antacid 2.8
Stimulant 1.6
Preservative 0.216
Preservative 0.024
Sweetener, energy 32 source
Suspension medium, 50.4 8 solvent, sweetener
Suspending agent, 0.24 thickener
Stomachic, flavorant 1.1052
Colorant 0.4
Suspension medium, 40 solvent, diluent
The specific formulation set forth above produces optimal therapeutic results within the permissible deviation indicated. However, certain individual ingredients may vary in amount, one at a time, over a wider range and still produce an efficacious composition. It may also be possible to vary the amounts of more than one ingredient at a time as long as the pH of the resulting composition does not fall outside a predetermined range, set forth hereinafter. For those ingredients which may vary beyond ±10%, the maximum ranges of variation are as follows:
Table l
Maximum Variation Substance from Example I Amounts
Acetaminophen
Magnesium trisilicate
Calcium citrate
Calcium carbonate
Caffeine
Dextrose
Spearmint oil
+50%,
-50%
+50%,
-50%
+50%,
-50%
+ 50%,
-50%
+50%,
-60%
+100%,
-75%
+100%,
-50%
lj
V
- . 1
While the dextrose can be increased 100% from Example I, this may require increasing the amount of water to prevent preciptation of the dextrose upon cooling of the composition.
The purified water in the composition of Example I serves as a diluent and may be added in any desired amount to produce the desired total volume of composition. The amount set forth in Example I is an amount which will result in an effective single dose having a volume of one tablespoon, i.e., 0.5 fluid ounce or approximately 15 ml. It will be appreciated that compositions with greater or lesser concentrations of the active ingredients could be used as long as a sufficient volume of the formulation is administered to deliver the effective amounts of the active ingredients. Those effective amounts are set forth in Table 2 for a 14.785 ml dose:
Table 2
Amount (mg.)/
Substance 14.785 ml Dose % w/w
25A217
Acetaminophen
1000
.23
Magnesium trisilicate
750
3.93
Calcium citrate,
1250
6.54
pulverized powder
Calcium carbonate, light
350
1.83
precipitated powder
Caffeine anhydrous
200
1.05
Methylparaben
27
0.14
Propylparaben
3
0.02
Dextrose
4000
.93
Glycerin
6310
33.02
Xanthan gum
0.16
Spearmint oil
138
0.72
Liquid caramel
50
0.26
Purified water
5000
26.17
In the composition of Example I the dextrose serves as a sweetener and as a source of energy. Any readily available carbohydrate may provide the source of energy, but
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250737
a sugar is selected, since it serves as a sweetner in addition to providing an energy source. More complex sugars, such as sucrose and lactose, could be used, but do not break down as rapidly and are, therefore, not as rapid a source of energy as a monosaccharide, such as fructose or dextrose. But, fructose tends to change color more readily to an undesirable mud-brown color. Thus, dextrose is preferred, since it exhibits much less color shift. Whatever small color shift may be exhibited by the dextrose is masked by the caramel colorant. The methylparaben and propylparaben serve as anti-bacterial preservative agents. The spearmint oil serves as a mild stomachic, a flavorant and a breath freshening agent.
As indicated above, a significant aspect of the invention is that it utilizes a unique combination of mild antacid agents. No strong antacids, such as hydroxides, are used. The resulting composition is basic, but has a ^ relatively low pH. More specifically, the pH of the composition is less than 9 and, preferably, in a range from about 8.2 to about 8.4 for the formulation of Example I.
This results in minimal degradation of the acetaminophen, producing a composition with a stable shelf life in excess of two years. The unique combination of antacid agents is such that it also provides auxiliary therapeutic functions.
Thus, the calcium citrate also serves as a calcium source, and the magnesium trisilicate also serves as a stomach protectant and adsorbent, as described below.
Another significant aspect of the invention is that theY composition is in the form of a suspension, the suspending medium consisting essentially of the glycerin, the xanthan gum acting as a suspending agent and the purified water,
%
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250737
with ■ the admixture of the other ingredients suspended therein. This permits the composition to be administered in liquid form, obviating the use of an auxiliary fluid, such as water or the like, which is necessary with pills or capsules to facilitate swallowing and dissolution in the stomach. The active ingredients in the suspension of the present invention are available for immediate action In the person being treated. The glycerin also serves as a sweetener.
The antacid agents are provided in a powdered or micro-pulverized form so as to provide a relatively smooth suspension. In this regard, commercially available calcium citirate "powder" is actually in a granular form which produces an unsuitably gritty suspension. Accordingly, the calcium citrate is finely ground in a hammer mill. Indeed, all of the powdered ingredients, including the antacid agents, the acetaminophen and the caffeine, are provided in a finely powdered form with a particle size which will pass through a 325 mesh screen. Also, the fine grinding of the antacids affords a greatly increased surface area to facilitate immediate action. Furthermore, the suspended form of magnesium trisilicate permits that ingredient to act not only as an antacid, but also as a stomach protectant or coater and as an adsorbent of undesirable elements in the gastro-intestina1 tract.
The suspension of the composition of Example I is preferably prepared in relatively large quantities. The method of preparation of one gallon of the composition of Example I is described in detail below, but it will be appreciated that larger quantities can be prepared by
8
scaling up the amounts appropriately. The prepar four-part process.
In Part I, 7.68 gin of xanthan gum is weighed and dispersed in 0.213 lbs. of glycerin. This dispersion is then dissolved in 0.2 gal. of purified water, mi;:ing continuously while adding the dispersion. The mixture is allowed to stand for a few hours to completely dissolve the gum. The resulting product is a pale white, translucent, smooth paste.
In Part II water-soluble ingredients are dissolved in water. More specifically, 6.912 gm. of methylparaben, 0.768 gm. of propylparaben and 2.256 lbs. of dextrose are dissolved in 0.133 gal. of purified water and heated to the boiling point and allowed to cool. The resulting product is a solution which is clear and colorless when hot, and cloudy when cooled.
In Part III, non-soluble powdered ingredients ground to a 325 mesh particle size, are mixed together with glycerin. More specifically, 0.564 lbs. of acetaminophen, 0.423 lbs. of magnesium trisilicate, 0.705 lbs. of calcium citrate in pulverized powder form, 0.197 lbs. of calcium carbonate in light precipitated powder form, and 0.113 lbs. of caffeine are mixed with 3.345 lbs. of glycerin in a blender or colloid mill to make a smooth paste. Then 38.4 ml. of spearmint oil is added to the suspension and mixed to dissolve the spearmint oil. There results a chalky white, smooth paste with a pleasant spearmint aroma.
In Part IV, the xanthan gum paste from Part I is added to the suspension from Part III, and then mixed continuously in a blender while adding the solution from Part II. Then 12.8 gm. of liquid*'caramel is added and mixed into the
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Claims (15)
- suspension. Enough purified water is added gallon, and the product is blended to make a uniform suspension. The resulting product is a caramel or coffee-colored suspension having a specific gravity betfl*en 1.20 and 1.21, a pH in the range from about 8.2 to about 8.4, an acid neutralizing capacity of from about 16 to about 18 meq. and with a total aerobic microbial count which does not exceed 100 per ml. and which meets the requirements of tests for absence of Escherichia coli and Pseudomonas aeruginosa.;The composition of Example I is administered orally in a single dose of one-half fluid ounce or one tablespoon, i.e., approximately 15 ml. The dosage may be repeated after four to six hours if symptoms persist.;From the foregoing, it can be seen that there has been provided an improved therapeutic composition for the treatment of the manifestations of hangover resulting from overindulgence in alcohol and a method of administration thereof, with the composition including acetaminophen and one or more antacid agents in a liquid suspension form with a pH which is mildly basic so as to provide effective therapeutic activity without degrading the acetaminophen.;10;•V;V';WHAT )^WE CLAIM IS:;250737;1. A therapeutic composition for oral administration comprising, in suspension in a non-toxic therapeutically acceptable suspension medium, a finely powdered form of each of;(a) a pain relieving amount of acetaminophen, and;(b) an acid neutralizing and stomach settling amount such that the composition is basic and has a pH less than 9.;
- 2. The therapeutic composition of claim 1, wherein said antacid agents include one or more of magnesium trisilicate, calcium citrate and calcium carbonate.;
- 3. The therapeutic composition of claim 1, and further comprising a carbohydrate energy source.;
- 4. The therapeutic composition of claim 3, wherein said energy source is dextrose.;
- 5. The therapeutic composition of claim 1, and further comprising a stomachic agent.;
- 6. The therapeutic composition of claim 5, wherein said stomachic agent is spearmint oil.;
- 7. The therapeutic composition of claim 1, and further comprising a stimulant.;of one or more mild antacid agents,;c;11;2 ^v';;I.;250737;•8. A therapeutic composition of matter including the following ingredients present in the recited approximate parts by weight:;Amount in Parts Ingredient by Weight ±10%;Acetaminophen
- 8.0;Magnesium trisilicate 6.0;Calcium citrate 10.0;Calcium carbonate 2.8;Caffeine 1.6;said ingredients being suspended in a suspension medium including the following constituents present in the recited approximate parts by weight:;Amount in Parts. Constituent by Weight ±10%;Glycerin 50.48;Xanthan gum 0.24;Purified water 40.0;
- 9. The therapeutic composition of claim 8, and further comprising one or more anti-bacterial preservative agents.;
- 10. The therapeutic composition of claim 9, wherein said preseirvative agents include approximately 0.216 parts by weight of methylparaben and approximately 0.024 parts by weight of propylparaben.;
- 11. The therapeutic composition of claim 8, and further comprising a carbohydrate energy source.;
- 12. The therapeutic composition of claim 11, wherein said energy source includes approximately 32.0 parts by weight of dextrose.'- /£\ ••:;A* ' Xf 25073?
- . 13. The therapeutic composition of claim 8, and further comprising approximately 1.1 parts by weight of spearmint oil.
- 14. The therapeutic composition of claim 8, and further comprising approximately 0.4 parts by weight of liquid caramel.
- 15. A therapeutic composition for oral administration substantially as described in this specification with reference to the Example. BARNETT LABORATORIES LIMITED 14 /4nd^O /By Their Attorneys BALDWIN, SON & CAREY
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ250737A NZ250737A (en) | 1994-01-21 | 1994-01-21 | Powdered suspension of acetaminophen with one or more antacid agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ250737A NZ250737A (en) | 1994-01-21 | 1994-01-21 | Powdered suspension of acetaminophen with one or more antacid agents |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ250737A true NZ250737A (en) | 1995-08-28 |
Family
ID=19924616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ250737A NZ250737A (en) | 1994-01-21 | 1994-01-21 | Powdered suspension of acetaminophen with one or more antacid agents |
Country Status (1)
Country | Link |
---|---|
NZ (1) | NZ250737A (en) |
-
1994
- 1994-01-21 NZ NZ250737A patent/NZ250737A/en unknown
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