NZ216930A - 2- or 3-nitratoalkyl- 1,4-benzodioxane derivatives; preparatory processes and pharmaceutical compositions - Google Patents

2- or 3-nitratoalkyl- 1,4-benzodioxane derivatives; preparatory processes and pharmaceutical compositions

Info

Publication number
NZ216930A
NZ216930A NZ216930A NZ21693086A NZ216930A NZ 216930 A NZ216930 A NZ 216930A NZ 216930 A NZ216930 A NZ 216930A NZ 21693086 A NZ21693086 A NZ 21693086A NZ 216930 A NZ216930 A NZ 216930A
Authority
NZ
New Zealand
Prior art keywords
integer
group
formula
nitratoalkyl
pharmaceutical compositions
Prior art date
Application number
NZ216930A
Inventor
Kunii Toshinobu
Minami Norio
Ozaki Fumihiro
Mori Nobuyuki
Takeda Mikio
Katoh Hiroshi
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NZ216930A publication Critical patent/NZ216930A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1,4-Benzodioxane derivatives represented by the following general formula: <CHEM> wherein p stands for an integer of 0 - 2, X and Y are same or different, and each represent a hydrogen atom; or a group represented by the formula -OR in which R denotes a hydrogen atom, a lower alkyl, lower alkoxycarbonyl or acyl group, or a group represented by the formula <CHEM> m being an integer of 1 or 2; cyano group; or carboxy group, n is an integer of 1 - 3, exclusive of the case wherein p = 0 and X = Y = H, or a pharmacologically acceptable salt thereof. Their process for the preparation, pharmacological compositions containing them as active ingredient, their use in the preparation of therapeutic and/or preventive medicament for the treatment of ischemic heart diseases or heart failure and for the control of blood pressure during surgical operations are also described.
NZ216930A 1985-07-23 1986-07-22 2- or 3-nitratoalkyl- 1,4-benzodioxane derivatives; preparatory processes and pharmaceutical compositions NZ216930A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60161096A JPS6222777A (en) 1985-07-23 1985-07-23 1,4-benzodioxane derivative

Publications (1)

Publication Number Publication Date
NZ216930A true NZ216930A (en) 1989-08-29

Family

ID=15728530

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ216930A NZ216930A (en) 1985-07-23 1986-07-22 2- or 3-nitratoalkyl- 1,4-benzodioxane derivatives; preparatory processes and pharmaceutical compositions

Country Status (13)

Country Link
US (2) US4794118A (en)
EP (2) EP0307970A1 (en)
JP (1) JPS6222777A (en)
KR (1) KR870001189A (en)
AT (1) ATE124692T1 (en)
AU (1) AU596108B2 (en)
CA (1) CA1277321C (en)
DE (1) DE3650347T2 (en)
DK (1) DK347486A (en)
ES (2) ES2004491A6 (en)
HU (1) HU203230B (en)
NZ (1) NZ216930A (en)
PH (1) PH23359A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63179868A (en) * 1987-01-21 1988-07-23 Eisai Co Ltd 1,4-benzodioxane derivative and production thereof
US5158956A (en) * 1990-05-04 1992-10-27 Eli Lilly And Company Method of inhibiting gastric acid secretion with benzodioxanes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3101345A (en) * 1960-04-29 1963-08-20 Thomae Gmbh Dr K 2-hydroxymethyl-8-hydroxy-1,4-benzodioxane
US3166573A (en) * 1963-11-08 1965-01-19 Colgate Palmolive Co 2-(nitratoalkyl)-1, 4-benzodioxanes

Also Published As

Publication number Publication date
ES2004491A6 (en) 1989-01-16
DE3650347T2 (en) 1996-01-25
EP0210581A1 (en) 1987-02-04
AU596108B2 (en) 1990-04-26
DK347486D0 (en) 1986-07-22
HU203230B (en) 1991-06-28
ATE124692T1 (en) 1995-07-15
EP0307970A1 (en) 1989-03-22
AU6042486A (en) 1987-01-29
HUT44776A (en) 1988-04-28
CA1277321C (en) 1990-12-04
EP0210581B1 (en) 1995-07-05
JPH0535150B2 (en) 1993-05-25
US4959376A (en) 1990-09-25
JPS6222777A (en) 1987-01-30
PH23359A (en) 1989-07-14
KR870001189A (en) 1987-03-12
DK347486A (en) 1987-01-24
US4794118A (en) 1988-12-27
ES2006545A6 (en) 1989-05-01
DE3650347D1 (en) 1995-08-10

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