NZ199957A - Pseudomonic acid as a growth/feed utilisation promoter in livestock - Google Patents
Pseudomonic acid as a growth/feed utilisation promoter in livestockInfo
- Publication number
- NZ199957A NZ199957A NZ199957A NZ19995782A NZ199957A NZ 199957 A NZ199957 A NZ 199957A NZ 199957 A NZ199957 A NZ 199957A NZ 19995782 A NZ19995782 A NZ 19995782A NZ 199957 A NZ199957 A NZ 199957A
- Authority
- NZ
- New Zealand
- Prior art keywords
- pseudomonic acid
- livestock
- salt
- ester
- feedstuff
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Description
New Zealand Paient Spedficaiion for Paient Number 1 99957
II99 o 5"
i
P^OTity Date(s}: ...
Complete Specification Filed: n
Class:
M l ' n 'ti 6'AUG 1985
f^Pication Date:
P.O. Journal, No: .. 1*73
No.:
Date:
new zealand patents act, 1953
complete specification
GROWTH PROMOTER
We, BEECHAM GROUP p. I.e. (Formerly Beecham Group Limited)
of Beecham House, Great West Road, Brentford, Middlesex, England,
hereby declare the invention for whichXK/ we pray that a patent may be granted to jne/us, and the method by which it is to be performed, to be particularly described in and by the following statement: -
(followed by la)
199 9 57
- la -
growth promoter
The present invention relates to the use of pseudomonic acid, its salts and esters, as growth promoting agents for livestock.
UK Patent No 1 395 907 discloses pseudomonic acid, of formula oh co2(ch2)8co2h oh and salts and esters thereof.
It has now been found that pseudomonic acid, its salts and esters, are surprisingly active as growth promoting agents for livestock, particularly for pigs.
I
199957
Accordingly, the present invention provides a method for improving the weight gain and feed utilisation efficiency of livestock, which method comprises administering pseudomonic acid or a salt or ester thereof to livestock in feedstuff wherein the pseudomonic acid or salt or ester thereof comprises from 2 to 200 ppm of the total feedstuff.
Preferred salts of pseudomonic acid are alkali metal or alkaline earth metal salts, and preferred esters are alkyl esters.
Preferably pseudomonic acid, sodium pseudomonate or methyl pseudomonate are used in the method of the present invention.
Whilst pseudomonic acid, its salts and esters, may be administered to any livestock, they are particularly suitable for improving the weight gain and feed utilisation efficiency of pigs.
Pseudomonic acid, its salts and esters, may be administered orally in the feedstuff provided for the livestock. Conveniently these are administered in the feedstuff at from 2 to 200 ppm, suitably less than 100 ppm.
For administration in feedstuff the drugs are conveniently formulated as a premix in association with a suitable carrier.
199957
Suitable carriers are inert conventional agents such as powdered starch. Other conventional feedstuff premix carriers may also be employed.
Pseudomonic acid, its salts and esters, may conveniently 5 be produced by fermentation of Pseudomonas Fluorescens
(NCIB 10586) as disclosed in UK Patent No 1 395 907. Modifications of this process are described in US Patent No 4 222 942 and European Patent Application No 0 005 614.
For use in the present invention, pseudomonic acid, 10 its salts and esters may be purified by techniques such as those described in the aforementioned patents, however, it may be uneconomic to undertake such purification and in this case either crude pseudomonic acid, or salts or esters thereof, may be employed, or the bacterial broth or solids 15 thereof from fermentation of Pseudomonas Fluorescens (NCIB
10586) may be used directly.
U
1
s
The present invention will now be illustrated with reference to the following Examples, which are not intended to limit the scope of the invention in any way.
1999 57
Example 1
Groups of pigs [8 or 10 Landrace x Large White c.a. 20 kg each, (equal numbers of females and castrate males) per group] were assigned to each of the following treatments:
Treatment g/tonne feed (free acid equivalent)
1 Negative control
2 Sodium pseudomonate 100
The pigs were fed ad libitum and weighed weekly for a period of twelve weeks.
The results of the experiment were as follows:
Treatment
Kg wt gain per pig
% improvement over negative control
Kg feed per Kg weight gain
% improvement of feed utilisation efficiency over negative control
1
2
56.5 61.7
+9.2
3.501 3.254
+ 7.1
199 9 57
_ 5 _
Example 2
Groups of pigs [8 or 10 Landrace x Large White c.a. 20 kg each, (equal numbers of females and castrate males) per group] were assigned to each of the following treatments:
Treatment g/tonne (free acid equivalent)
1 Negative control
2 Sodium pseudomonate
3 Sodium pseudomonate
4 Sodium pseudomonate
40 100
The pigs were fed ad libitum and weighed weekly for a period of six weeks.
The results of the experiment were as follows:
Treatment Kg wt gain % improvement Kg feed per % improvement of per pig over negative kg weight feed utilisation control gain efficiency over negative control
1
2
3
4
29.30 31.40 30.92 31.00
+ 7.1 + 5.5 + 5.8
3.142 3.046 3.044 3.073
+ 3.1 + 3.2 + 3.2
299957
Claims (8)
1. A method for improving the weight gain and feed utilisation efficiency of livestock, which method comprises administering pseudomonic acid or a salt or ester thereof to livestock in feedstuff wherein the pseudomonic acid or salt or ester thereof comprises from 2 to 200 ppm of the total feedstuff.
2. A method according to claim 1 wherein the pseudomonic acid or salt or ester thereof comprises up to 100 ppm of the total feedstuff.
3. A method according to claim 1 or claim 2, wherein pseudomonic acid or an alkali metal or alkaline earth metal salt thereof is administered to livestock.
4. A method according to claim 3, wherein pseudomonic acid or the sodium salt thereof is administered to livestock.
5. A method according to claim 1 or claim 2, wherein an alkyl ester of pseudomonic acid is administered to livestock.
6. A method according to claim 5 wherein methyl pseudomonate is administered to livestock.
7. A method according to claim 1 or claim 2, wherein the pseudomonic acid or salt or ester thereof is administered as a feedstuff premix in association with a conventional feedstuff premix carrier.
8. Pseudomonic acid or a salt or ester thereof for use in a method according to claim 1. H % ?
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8107710A GB2097670B (en) | 1981-03-11 | 1981-03-11 | Growth promotor containing pseudomonic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ199957A true NZ199957A (en) | 1985-08-16 |
Family
ID=10520325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ199957A NZ199957A (en) | 1981-03-11 | 1982-03-09 | Pseudomonic acid as a growth/feed utilisation promoter in livestock |
Country Status (7)
| Country | Link |
|---|---|
| AU (1) | AU549767B2 (en) |
| BE (1) | BE892450A (en) |
| GB (1) | GB2097670B (en) |
| HK (1) | HK94886A (en) |
| IE (1) | IE52833B1 (en) |
| IT (1) | IT1148122B (en) |
| NZ (1) | NZ199957A (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3273944D1 (en) * | 1982-05-06 | 1986-12-04 | Beecham Group Plc | A method for improving the weight gain and feed utilisation efficiency of pigs |
| GB8415579D0 (en) * | 1984-06-19 | 1984-07-25 | Beecham Group Plc | Compounds |
| GB8428952D0 (en) * | 1984-11-16 | 1984-12-27 | Beecham Group Plc | Formulations |
| US5594026A (en) * | 1990-12-11 | 1997-01-14 | Smithkline Beecham Group P.L.C. | Polymorphs of crystalline mupirocin |
| GB9026873D0 (en) * | 1990-12-11 | 1991-01-30 | Beecham Group Plc | Novel compounds |
-
1981
- 1981-03-11 GB GB8107710A patent/GB2097670B/en not_active Expired
-
1982
- 1982-03-09 IT IT47949/82A patent/IT1148122B/en active
- 1982-03-09 NZ NZ199957A patent/NZ199957A/en unknown
- 1982-03-10 BE BE0/207535A patent/BE892450A/en not_active IP Right Cessation
- 1982-03-10 AU AU81272/82A patent/AU549767B2/en not_active Ceased
- 1982-03-10 IE IE545/82A patent/IE52833B1/en unknown
-
1986
- 1986-12-04 HK HK948/86A patent/HK94886A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE820545L (en) | 1982-09-11 |
| IE52833B1 (en) | 1988-03-16 |
| GB2097670A (en) | 1982-11-10 |
| IT8247949A0 (en) | 1982-03-09 |
| BE892450A (en) | 1982-09-10 |
| AU8127282A (en) | 1982-09-16 |
| AU549767B2 (en) | 1986-02-13 |
| IT1148122B (en) | 1986-11-26 |
| GB2097670B (en) | 1985-02-27 |
| HK94886A (en) | 1986-12-12 |
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