NZ189818A - 1-oxa-4-aza-2,6-disilacyclohexanes and pharmaceutical compositions - Google Patents

Description

New Zealand Paient Spedficaiion for Paient Number 1 89818 1 898 1 8 F'iad" & ' 3' 7^ colFikn AfciK3 fl e « ■» 1 n/j c » s iiitiaiiaiiit 12^8 ^ pfj>, ps. fpc?rj st ^ ^ r> '■ :" ". 1 '.'." {-] y p-M. tew? te g la NEW ZEALAND No.: Date: PATENTS ACT, 1953 p" K -5 MAR 1979 -scevno COMPLETE SPECIFICATION 1-OXA-4-AZA-2,6-DISILACYCLOHEXANES THEIR PRODUCTION AND USE AS MUSCLE RELAXANTS -WWe, SANDOZ LTD, 35 Lichtstrasse, 4002 Basle, Switzerland, a Swiss Body Corporate hereby declare the invention for which "f / we pray that a patent may be granted to^we^us, and the method by which it is to be performed, to be particularly described in and by the following statement:- - 1 - (followed by page la) I P 9 Q I o I 0 Jo I 0 - la - The invention provides compounds of formula I, ■<l3T R R- R. j ^ /4 i / si\ • CH-—N O ' 2 s Si-' / \ R, in which either R^ and R2 are independently hydrogen, fluorine, chlorine, alkyl or alkoxy of 1 to 4 carbon atoms, or tri-fluoromethyl, or R^ is - (CI^) nN (R-y)(Rg), in which R^ and Rg are independently hydrogen, methyl or ethyl, and n is 0 or 1, and R2 is hydrogen, and R^, R^, R5 and Rg are independently methyl or ethyl, in free base or acid addition salt form.

The invention also provides a process for the production of compounds of formula I, or acid addition salts thereof,^ comprising condensing a compound of formula II, / a\ 1 0 0 01 0 1 0 J u I u R3 Y - CH 2 0 II / R Y - CH 6 in which R_, R., Rc and R, are as defined above, and 3 4' 5 6 the Y's each represent a leaving group, ) with a compound of formula III# •2 ch2-nh2 III in which R^ and R2 are as defined above, and if required converting a compound of the formula I thus obtained into an acid addition salt thereof or vice versa.

Suitable leaving groups Y include alkyl or aryl-sulphonate groups, e.g. tosylate and mesylate groups, and halogen atoms, e.g. iodo, bromo or chloro. Preferably, the groups Y are identical.

The process may be carried out in conventional manner, suitably in the presence of an acid binding agent, such as a tertiary amine, e.g. pyridine, triethylamine or di-isopropylamine, or an alkali metal hydroxide or hydride, such as potassium or sodium hydroxide, or lithium hydride. Alternatively, an excess of the compound of formula III may 1 898 1 8 GOO-GQir— be employed to serve as acid binding agent. Preferably, no solvent is employed, but, if desired, an inert aprotic solvent such as acetonitrile, dimethylformamide, or dimethyl-acetamide, or a protic solvent, such as a C^_^alkanol, e.g. methanol or ethanol, may be used. The process is conveniently effected at a temperature of from -10° to +100°C, preferably 20° to 30°C, and the reaction time may vary typically from 2 to 12 hours, more usually about 3 to 5 hours.

The resulting compounds of formula I may be isolated and purified using conventional techniques. Where required, free base forms of the compounds may be converted into acid addition salt forms in conventional manner, and vice versa.

The compounds of formula II and III are either known 15 or may be prepared in conventional manner from available materials.

The compounds of formula I possess pharmacological activity. In particular, they possess muscle relaxant activity, as indicated 1) by their activity in the rotorod 20 test as described by Dunham and Miya [J. Am. Pharm. Assoc., 45, 208,(1957)], 2) by their ability to depress spinal reflexes measured by flexor and patellar responses using force displacement transducers in male cats given 0.1 to 3.0 mg/kg of animal body weight, i.v. of the test compound, - 4 - COO COl- L8 98 and 3) by their ability to produce docility in behaviour tests in mice given 25 to 200 mg/kg of animal body weight, i.p. of the-test compound according to the 30-word adjective check sheet system basically as described by Irwin S.

(Gordon Research Conference, Medicinal Chemistry, 1959), and Chen (Symposium on Sedative and Hypnotic Drugs, Williams and Wilkins, 1954).

The compounds are therefore indicated for use as muscle relaxants. An indicated suitable daily dosage is 10 from 5 to 500 mg, suitably administered in divided doses of from 1.25 to 250 mg two to four times daily, or in sustained release form.

The compounds may be administered in free base form, or in the form of physiologically acceptable acid addition 15 salts, which salt forms have the same order of activity as the free base forms. Suitable salt forms include mineral' acid salt forms, e.g. the hydrochloride, hydrobromide or sulphate.

The compounds may be administered alone, or in ad-20 mixture with a pharmaceutically acceptable diluent or carrier, and, optionally, other excipients, and administered orally in such forms as tablets, elixirs, capsules or suspensions, or parenterally in such forms as injectable solutions or suspensions. 1898 18 - 5 - ■■ GOO GOll The preferred compounds of formula I are those in which R3, R4# R,. and Rg each signify methyl. Particularly preferred are those in which one of R-^ and R2 is hydrogen and the other is C^^alkoxy, more particularly methoxy.

The most preferred compound is that of Example 2 hereinafter.

The following Examples illustrate the invention. 1 8 98 1 8 COO GOll EXAMPLE 1; 4-Benzy1-2,2,6,6-tetramethyl-l-oxa-4-aza-2,6-dlsilacyclohexane An amount of 33.6 g (0.315 mole) of benzylamine is added over a period of approximately 5 minutes to 41.4 g 5 (0.1 mole) of 1,3-bis-iodomethyl-l,1,3,3-tetramethyl-disiloxane, with stirring, in a bath at room temperature. Stirring is continued at room temperature for one hour. (A slurry results). Addition of 50 ml of acetonitrile gives a clear solution which is then heated to reflux for 2 hours. The cooled solution is distributed between approx-« imately 0.5 1 of pentane and 1.5 1 of water. The aqueous layer is then extracted with one more approximately 200 ml portions of pentane, and the combined organic layer is washed twice with approximately 300 ml of water, dried over anhydrous sodium sulphate, filtered and evaporated in vacuo to' provide a clear yellow mobile liquid. This product is then vacuum distilled to give 4-benzyl-2,2,6,6-tetramethyl-l-oxa-4-aza-2,6-disilacyclohexane, b.p. 134° to 135°C, at 13 mm Hg.

The hydrochloride salt of the title compound is prep ared by dissolving 10.0 g (37.7 m moles) of the free base in 150 ml of diethylether. There is then injected, with stirring and ice-cooling, 900 ml of hydrogen chloride gas. The resulting slurry is allowed to stand at 0° overnight, 18 9818 600-6811 filtered and the precipitate is washed with more ether and dried at 110°C in vacuo to give the hydrochloride salt form, m.p. 250 to 251°C.

EXAMPLE 2: 4-(m-Methoxybenzy1)-2,2,6,6-tetramethy1-1-oxa-5 4-aza-2,6-disilacyclohexane A solution containing 92.4 g (400 m moles) of 1,3-bis-chloromethyl-1,1,3,3-tetramethyldisiloxane and 100 g of acetonitrile, dried over molecular sieves, is heated to 90°C bath temperature. To this solution, there is added, 10 with stirring, a solution of 55 g (400 m moles) of m- methoxybenzylamine in 88.8 g (2 x 1.1 x 400 = 880 m moles) of triethylamine, over a period of 25 minutes. A solid separates in the reaction mixture from the time at which about half the amine is added. The mildly exothermic 15 reaction keeps the mixture refluxing. The resulting slurry is stirred for an additional 4-3/4 hours, then cooled in ice. Toluene (/v0.5 1) is then added and the mixture is extracted with 1 litre of water; the latter is washed with 100 ml of toluene. The combined organic phase is washed 20 with two 500 ml portions of water and concentrated in vacuo first at 40°C then at 60°C. The resultant oil is distilled through a short Vigreux column to give 4-(m-methoxybenzyl)-2,2,6,6-tetramethyl-l-oxa-4-aza-2,6-disilacyclohexane. 1 898 1 8 - 8 - ■ 600-6811 The hydrochloride salt of the title compound is prepared in the following manner.

A solution of 13.5 ml of aqueous concentrated hydrochloric acid (slight excess over 135 m mol) in 50 ml of 5 acetone is added, without cooling, to a solution of 40 g (135 m mol) of 4-(m-methoxybenzyl)-2,2,6,6-tetramethyl-l-oxa-4-aza-2,6-disilacyclohexane in 100 ml of acetone. An additional 50 ml of acetone is added to facilitate stirring.' The resultant white slurry is stirred for 10 min-10 utes, then 100 ml of ethyl acetate is added, while continuing stirring for an additional 10 minutes. The mixture is then allowed to stand at 0°C for 3 hours. The resulting slurry is then filtered and the precipitate is washed with 60 ml of 1:1 acetone:ethyl acetate, then with 50 ml of 15 ethyl acetate; the solids are resuspended in each portion of wash. The resulting product is dried overnight in vacuo at 100°C to give the hydrochloride salt form, m.p. 230° to 231.5°C.

EXAMPLES 3 to 13: In manner analogous to that of Example 1, employing appropriate starting materials in approximately equivalent amounts, the compounds of formula I, set out in the following Table, may be obtained. 1 898 - 9 - GOO COll NO. r1 r2 r3 r4 R5 R6 Salt Form m.p. °C 3 h £-Cl ch3 ch3 ch3 ch3 4 h £-F ch3 ch3 ch3 ch3 HCl 247-248° H P-CH3 ch3 ch3 ch3 ch3 HCl 245-246° 6 H £-CH30 ch3 ch3 ch3 ch3 HCl 223° 7 3-c1 4-c1 ch3 ch3 ch3 ch3 • 8 H 3-cf3 ch3 ch3 ch3 ch3 HCl 233-234° 9 H 4- (ch3)2n- ch3 ch3 ch3 ch3 H 4- (ch )2nch2" ch3 ch3 ch3 ch3 11 h m-Cl ch3 ch3 ch3 ch3 HCl 273° 12 H m-ch3 ch3 ch3 ch3 ch3 HCl 250° 13 H o-Cl ch3 ch3 ch3 ch3 HCl 221-222° 1 898 1 8 - 10 - GOO C011-

Claims (10)

WHAT WE CLAIM IS:

1. Compounds of formula I, R., R. \3 /4 r^X>~ch2-<:;> 2 / \ R5 R6 * in which either R^ and R2 are independently hydrogen, fluorine, chlorine, alkyl or alkoxy of 1 to 4 carbon atoms, or tri-5 fluoromethyl, or R1 is -(CH2)nN(R?)(Rg), in which R? and Rg are independently hydrogen, methyl or ethyl, and n is 0 or 1, and R2 is hydrogen, 10 and R^, R^, R5 and Rg are independently methyl or ethyl, in free base or acid addition salt form. - 11 - I89SI8

2. Compounds of Claim 1, in which , R^, R^ and Rg are all methyl.

3. Compounds of Claim 1 or 2, in which one of R^ and R2 is hydrogen and the other is C^_C^alkoxy.

4. Compounds of any one of Claims 1, 2 or 3 in which one of R^ and R2 is hydrogen and the other is methoxy.

5. 4-Benzyl-2/2,6,6-tetramethyl-l-oxa-4-aza-2,6-disilacyclohexane, or an acid addition salt thereof.

6. 4-(m-Methoxybenzyl)-2,2,6,6-tetramethyl-l-oxa-4-aza-2,6-disilacyclohexane, or an acid addition salt thereof.

7. A compound of Claim 1, in which R^, R^, Rj. and Rg are all methyl, and R^ is hydrogen and R2 is £-fluoro-, £-methyl, £-methoxy, m-chloro, m-methyl or o-chloro, or an acid addition salt thereof.

8. A process for the production of a compound of formula I, stated in Claim 1, or an acid addition salt thereof, comprising condensing a compound of formula II, R3 0 Y - CH 2 5 II in which R^, R^, R^ and Rg are as defined above, and the Y's each represent a leaving group, - 12 - 189818 with a compound of formula III R 1 III CH2-NH2 R 2 in which R^ and R2 are as defined above, and if required converting a compound of the formula I thus obtained into an acid addition salt thereof or vice versa.

9. A process for the production of a compound of formula I, stated in Claim 1, substantially as hereinbefore described with reference to any one of the Examples.

10. A pharmaceutical composition comprising a compound of formula I, stated in Claim 1, in free base or physiologically acceptable acid addition salt form, in association with a pharmaceutically acceptable diluent or carrier. dated this V)^L DAY OF