NO972314L - Neisseria meningitidis TBP2 subunit - Google Patents

Neisseria meningitidis TBP2 subunit

Info

Publication number
NO972314L
NO972314L NO972314A NO972314A NO972314L NO 972314 L NO972314 L NO 972314L NO 972314 A NO972314 A NO 972314A NO 972314 A NO972314 A NO 972314A NO 972314 L NO972314 L NO 972314L
Authority
NO
Norway
Prior art keywords
tbp2
subunit
meningitidis
strain
neisseria meningitidis
Prior art date
Application number
NO972314A
Other languages
Norwegian (no)
Other versions
NO972314D0 (en
Inventor
Marie-Jose Quentin-Millet
Bachra Rokbi
Original Assignee
Pasteur Merieux Serums Vacc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Merieux Serums Vacc filed Critical Pasteur Merieux Serums Vacc
Publication of NO972314D0 publication Critical patent/NO972314D0/en
Publication of NO972314L publication Critical patent/NO972314L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Det beskrives et i det vesentlige rensel protein, dvs, underenheten (Tbp2) med lavere molekylvekt av den humane transferriiu-eseptoren (HTR) av en N. meningilidis-stamme som er karakterisert ved at det ikke gjenkjennes i en doi blol-analyse av et antisenam til et polypeptid som tilsvarer Tbp2 i N. meningitidis-stamme M982 (Tbp2 M982) hvorfra de hypervariable delene i det andre området er fjernet. Tbp2-underenhelen er karakterisert (i) ved al den kodes av et DNA-fragment på rundt 2,1 kb, og (ii) ved al den har en hengselregion av M982-typen. Nevnte Tbp2-underenhel og de polypeptidfragmenler som er oppnådd derfra er spesielt anvendbare som vaksiner, spesielt når de kombineres med kjente N. meningitidis Tbp2-underenheter. DNA- fragmenter som koder for den nye Tbp2 og avledede polypeptider beskrives også.A substantially purified protein, that is, the lower molecular weight subunit (Tbp2) of the human transferri receptor (HTR) of an N. meningilidis strain, is characterized which is not recognized in a doi blol analysis of a antisenam to a polypeptide corresponding to Tbp2 in N. meningitidis strain M982 (Tbp2 M982) from which the hypervariable moieties of the second region are removed. The Tbp2 subunit is characterized (i) by all of it encoded by a DNA fragment of about 2.1 kb, and (ii) by all of it having a M982-type hinge region. Said Tbp2 subunit and the polypeptide fragments obtained therefrom are particularly useful as vaccines, especially when combined with known N. meningitidis Tbp2 subunits. DNA fragments encoding the new Tbp2 and derived polypeptides are also described.

NO972314A 1995-10-10 1997-05-21 Neisseria meningitidis TBP2 subunit NO972314L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9512106A FR2739624B1 (en) 1995-10-10 1995-10-10 NEW NEISSERIA MENINGITIDIS TBP2 SUBUNIT
PCT/FR1996/001580 WO1997013860A1 (en) 1995-10-10 1996-10-10 Neisseria meningitidis subunit tbp2

Publications (2)

Publication Number Publication Date
NO972314D0 NO972314D0 (en) 1997-05-21
NO972314L true NO972314L (en) 1997-07-18

Family

ID=9483560

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972314A NO972314L (en) 1995-10-10 1997-05-21 Neisseria meningitidis TBP2 subunit

Country Status (7)

Country Link
EP (1) EP0796332A1 (en)
JP (1) JPH11500630A (en)
CA (1) CA2207302A1 (en)
FR (1) FR2739624B1 (en)
HU (1) HUP9801714A3 (en)
NO (1) NO972314L (en)
WO (1) WO1997013860A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2767060B1 (en) * 1997-08-07 2000-02-11 Pasteur Merieux Serums Vacc MENINGOCOCCAL VACCINE WITH BZ83 STRAIN VALENCE
JP5102414B2 (en) 1998-05-01 2012-12-19 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Meningococcal antigens and compositions
AU2012203235B2 (en) * 1998-05-01 2014-04-24 Glaxosmithkline Biologicals Sa Neisseria meningitidis antigens and compositions
GB9902084D0 (en) * 1999-01-29 1999-03-24 Smithkline Beecham Biolog Novel compounds
CN100392082C (en) 1999-04-30 2008-06-04 启龙股份公司 Conserved neisserial antigens
DK2270173T3 (en) 1999-05-19 2016-03-07 Glaxosmithkline Biolog Sa Neisserial combination compositions
GB9928196D0 (en) 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
MXPA02008314A (en) * 2000-02-28 2002-12-09 Chiron Spa Heterologous expression of neisserial proteins.
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
CA2501812C (en) 2002-10-11 2012-07-10 Mariagrazia Pizza Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
CA2810971C (en) 2010-09-10 2020-11-03 Novartis Ag Developments in meningococcal outer membrane vesicles
WO2013186753A1 (en) 2012-06-14 2013-12-19 Novartis Ag Vaccines for serogroup x meningococcus
WO2016091902A1 (en) * 2014-12-09 2016-06-16 Sanofi Pasteur Compositions comprising n. meningitidis proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2682041B1 (en) * 1991-10-03 1994-01-14 Pasteur Merieux Serums Vaccins VACCINE AGAINST NEISSERIA MENINGITIDIS INFECTIONS.
FR2692592B1 (en) * 1992-06-19 1995-03-31 Pasteur Merieux Serums Vacc DNA fragments encoding the Neisseria meningitidis transferrin receptor subunits and methods of expressing them.
FR2720408B1 (en) * 1994-05-31 1996-08-14 Pasteur Merieux Serums Vacc Fragments Tbp2 of Neisseria meningitidis.

Also Published As

Publication number Publication date
HUP9801714A2 (en) 1998-10-28
WO1997013860A1 (en) 1997-04-17
CA2207302A1 (en) 1997-04-17
HUP9801714A3 (en) 2000-03-28
AU7221396A (en) 1997-04-30
FR2739624A1 (en) 1997-04-11
NO972314D0 (en) 1997-05-21
FR2739624B1 (en) 1997-12-05
JPH11500630A (en) 1999-01-19
EP0796332A1 (en) 1997-09-24
AU720789B2 (en) 2000-06-15

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