NO971836L - Recombinant Alternaria alternata allergens - Google Patents

Recombinant Alternaria alternata allergens

Info

Publication number
NO971836L
NO971836L NO971836A NO971836A NO971836L NO 971836 L NO971836 L NO 971836L NO 971836 A NO971836 A NO 971836A NO 971836 A NO971836 A NO 971836A NO 971836 L NO971836 L NO 971836L
Authority
NO
Norway
Prior art keywords
protein
allergens
alt
allergen
recombinant
Prior art date
Application number
NO971836A
Other languages
Norwegian (no)
Other versions
NO971836D0 (en
Inventor
Gernot Achatz
Erich Lechenauer
Birgit Simon
Dietrich Kraft
Michael Breitenbach
Andrea Unger
Hannes Oberkofler
Christoph Ebner
Hans-Joerg Prillinger
Original Assignee
Biomay Prod & Handel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomay Prod & Handel filed Critical Biomay Prod & Handel
Publication of NO971836D0 publication Critical patent/NO971836D0/en
Publication of NO971836L publication Critical patent/NO971836L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Denne oppfinnelsen vedrører den fullstendige cDNA-sekvens av Alternaria alternata-allergenene Alt a 45 og Alt a 12. Det er blitt mulig innenfor rammen av den molekylærbiologiske analyse av allergenene å identifisere Alt a 45 som en proteindisulfidisomerase. Dette protein er et 45 kD stort protein som 47% av pasientene reagerer på, og er således et viktig primært allergen. Alt a 12 som 8% av pasientene reagerer på ble identifisert som et ribosomalt protein som er av interesse fordi autoantistoffer mot ribosomale proteiner blir funnet i pasienter som lider av lupus. Det gjenstår å se hvorvidt det er en eventuell forbindelse mellom allergi mot muggsopp og autcimmuniske sykdommer. Ved anvendelse av denne rekombinante sekvens og datamaskinanalyse er det blitt mulig å identifisere svært potente B- og T- celieepitoper og å anvende peptidene avledet fra de rekombinante proteiner for diagnosen av allergi mot alternaria alternata muggsopper. Peptidene har også vist seg egnet både for in vitro og in vivo allergenspesifik stimulering av T-celler proliterasjon, interleukinfremstiiling, og for blokkering av T-cellcne som resulterer i en toleranse av de allergenspesifikke T-lymfocytter.This invention relates to the complete cDNA sequence of Alternaria alternata allergens Alt a 45 and Alt a 12. It has become possible in the context of the molecular biological analysis of the allergens to identify Alt a 45 as a protein disulfide isomerase. This protein is a 45 kD protein that 47% of patients respond to, and is thus an important primary allergen. All α 12 to which 8% of patients respond was identified as a ribosomal protein of interest because autoantibodies to ribosomal proteins are found in patients suffering from lupus. It remains to be seen whether there is a possible link between allergy to mold and autoimmune diseases. Using this recombinant sequence and computer analysis, it has become possible to identify very potent B and T cell epitopes and to use the peptides derived from the recombinant proteins for the diagnosis of allergy to alternaria alternate mold fungi. The peptides have also been found to be suitable for both in vitro and in vivo allergen-specific stimulation of T-cell proliferation, interleukin production, and for blocking T-cells resulting in a tolerance of the allergen-specific T-lymphocytes.

NO971836A 1994-11-02 1997-04-21 Recombinant Alternaria alternata allergens NO971836L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0203894A AT401181B (en) 1994-11-02 1994-11-02 RECOMBINANT DNA MOLECULES
PCT/AT1995/000212 WO1996014407A1 (en) 1994-11-02 1995-10-31 Recombinant alternaria alternata allergens

Publications (2)

Publication Number Publication Date
NO971836D0 NO971836D0 (en) 1997-04-21
NO971836L true NO971836L (en) 1997-06-25

Family

ID=3526463

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971836A NO971836L (en) 1994-11-02 1997-04-21 Recombinant Alternaria alternata allergens

Country Status (8)

Country Link
EP (1) EP0787184A1 (en)
JP (1) JPH10508474A (en)
AT (1) AT401181B (en)
AU (1) AU3736795A (en)
CA (1) CA2204362A1 (en)
FI (1) FI971894A0 (en)
NO (1) NO971836L (en)
WO (1) WO1996014407A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201209862D0 (en) 2012-06-01 2012-07-18 Circassia Ltd Cladosporium peptides

Also Published As

Publication number Publication date
FI971894A (en) 1997-05-02
CA2204362A1 (en) 1996-05-17
NO971836D0 (en) 1997-04-21
AU3736795A (en) 1996-05-31
EP0787184A1 (en) 1997-08-06
FI971894A0 (en) 1997-05-02
AT401181B (en) 1996-07-25
ATA203894A (en) 1995-11-15
WO1996014407A1 (en) 1996-05-17
JPH10508474A (en) 1998-08-25

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