NO970366L - imidazopyridine - Google Patents
imidazopyridineInfo
- Publication number
- NO970366L NO970366L NO970366A NO970366A NO970366L NO 970366 L NO970366 L NO 970366L NO 970366 A NO970366 A NO 970366A NO 970366 A NO970366 A NO 970366A NO 970366 L NO970366 L NO 970366L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- hydrogen
- alkenyl
- bond
- substituted
- Prior art date
Links
- GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical compound C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 abstract 1
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 abstract 1
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 102000003710 Histamine H2 Receptors Human genes 0.000 abstract 1
- 108090000050 Histamine H2 Receptors Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 108700023400 Platelet-activating factor receptors Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 102000030769 platelet activating factor receptor Human genes 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Forbindelser med formel (II) hvor L og A er slik at (i) L er en uforgrenet, mettet eller umettet, to- verdig hydrokarbonkjede med opp til 6 karbonatomer og A er en binding, eller (ii) L er en binding eller -CHj- og A er en toverdig 1,4-fenylengruppe som kan være substituert med Ci-Cj-alkyl, Cj-C^- alkenyl, cyan, halogen eller C^-C^- alkoksy; X er (a) -0-; eller (b) -N(rM-, hvor R^ er hydrogen, Cj-Cj- alkyl, C2-Cs-alkenyl, Cj-C^-alkynyl, Cj-Cg-sykloalkyl eller ikke-aromatisk 5- 7-heterosyklyl, hvor alle kan være sub- stituert med én eller flere Cj-Cj- alkyl-, -(C=0)0(Ci-C,-alkyl)-, -COOH- eller fenylgrupper; R^ er hydrogen, Cj- Cj-alkyl, Cj-Cj-alkenyl, C^-Ct-alkynyl, Cj-Cg-sykloalkyl eller ikke-aromatisk 5- 7-heterosyklyl som kan være substituert med én eller flere Ci-Cj-alkyl-, -(C=0)0(Ci-C4-alkyl)-, -COOH- eller fenylgrupper; B er en binding eller en rettkjedet eller forgrenet, mettet eller umettet, toverdig hydrokarbon- kjede med opp til 3 karbonatomer; R^ er hydrogen, Cj-C,-alkyl, halogen, cyan, trifluormetyl eller Cj-C^-alkoksy; W er -N= eller -C=; D er hydrogen eller hydroksyl og E er hydrogen, eller D og E er tilsammen -C=C-; R* og R^ er uav- hengig av hverandre Ci-C,-alkyl eller danner sammen med nitrogenatomet som de er bundet til, en ikke-aromatisk, heterosyklisk 5-7 ring som kan inne- holde ett eller flere andre hetero- atomer enn nitrogenatomet som R'' og R er bundet til; eller et farmasøytisk eller veterinærmedisinsk akseptabelt syreaddisjonssalt, solvat eller hydrat derav, er doble histamin Hj- og PAF- reseptorantagonister.Compounds of formula (II) wherein L and A are such that (i) L is a unbranched, saturated or unsaturated, dihydric hydrocarbon chain of up to 6 carbon atoms and A is a bond, or (ii) L is a bond or - CH 2 and A are a divalent 1,4-phenylene group which may be substituted by C 1 -C 2 alkyl, C 1 -C 4 alkenyl, cyano, halogen or C 1 -C 4 alkoxy; X is (a) -O-; or (b) -N (rM- where R 1 is hydrogen, C 1 -C 3 alkyl, C 2 -C 8 alkenyl, C 1 -C 6 alkynyl, C 1 -C 6 cycloalkyl or non-aromatic 5-7-heterocyclyl, wherein all may be substituted by one or more C 1 -C 2 alkyl-, - (C = O) O (C 1 -C 1 -alkyl) -, -COOH or phenyl groups; R 1 is hydrogen, C alkyl, Cj-Cj alkenyl, C ^-Ct alkynyl, Cj-Cg cycloalkyl or non-aromatic 5-7-heterocyclyl which may be substituted by one or more C--Cj alkyl-, - (C = O) O (C 1 -C 4 alkyl) -, -COOH or phenyl groups; B is a bond or a straight chain or branched, saturated or unsaturated, dihydric hydrocarbon chain having up to 3 carbon atoms; R 1 is hydrogen, C alkyl, halogen, cyano, trifluoromethyl or C C-C ^ alkoxy; W is -N = or -C =; D is hydrogen or hydroxyl and E is hydrogen or D and E are together -C = C-; R * and R 1 is independently C 1 -C 4 -alkyl or together with the nitrogen atom to which they are attached form a non-aromatic heterocyclic 5-7 ring which may contain one or more other heterocyclic moieties. omer than the nitrogen atom to which R 1 and R are bonded; or a pharmaceutically or veterinarily acceptable acid addition salt, solvate or hydrate thereof, are double histamine H 2 and PAF receptor antagonists.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO970366A NO970366L (en) | 1997-01-28 | 1997-01-28 | imidazopyridine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO970366A NO970366L (en) | 1997-01-28 | 1997-01-28 | imidazopyridine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO970366D0 NO970366D0 (en) | 1997-01-28 |
| NO970366L true NO970366L (en) | 1998-07-29 |
Family
ID=19900306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO970366A NO970366L (en) | 1997-01-28 | 1997-01-28 | imidazopyridine |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO970366L (en) |
-
1997
- 1997-01-28 NO NO970366A patent/NO970366L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO970366D0 (en) | 1997-01-28 |
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