NO963764L - New use of quinoline-3-carboxamide compounds - Google Patents
New use of quinoline-3-carboxamide compoundsInfo
- Publication number
- NO963764L NO963764L NO963764A NO963764A NO963764L NO 963764 L NO963764 L NO 963764L NO 963764 A NO963764 A NO 963764A NO 963764 A NO963764 A NO 963764A NO 963764 L NO963764 L NO 963764L
- Authority
- NO
- Norway
- Prior art keywords
- quinoline
- inflammatory bowel
- disease
- bowel disease
- atoms
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Anvendelse av en kinolin-3-karboksamidforbindelse mot inflammatorisk tarmsykdom, hvilken forbindelse omfatter strukturen (I) ovenfor, valgfritt med substituenter for de viste hydrogenatomer (H1"9) , eller et farmasøytisk akseptabelt salt av forbindelsen, hvor (a) ----- betyr at det er to konjugerte dobbeltbindinger mellom atome- ne, hvilke bindinger representeres med den stiplede linje; (b) X, og X2 hver uavhengig utvelges fra et oksygenatom og en NH9-gruppe, hvor X, og X2 er bundet til ringen med en enkeltbinding når de er forbundet med H7 eller H8, og med en dobbeltbinding når de ikke er forbundet med H7 eller H8; (c) H1"9 hver betyr et hydro- genatom, med det forbehold at H9 kun forekommer når minst en av X, og X2 betyr en NH9-gruppe; (d) H7 og H8 hver betyr et hydrogenatom som er forbundet med for- skjellige atomer utvalgt fra X,, X2 og nitrogenatomet (N) i kinolinringen, ved fremstilling av en sammenset- ning for behandling av inflammatorisk tarmsykdom eller tilstander forbundet med denne sykdom. Det beskrives også fremgangsmåter ved behandling av inflammatorisk tarmsykdom eller tilstander forbundet med denne sykdom, ved hvilke fremgangsmåter ovennevnte forbindelser administreres til et levende vesen. Spesielt foretrukne forbindelser er N-fenyl-N-metyl-l,2-dihydro-4-hydroksy- l-metyl-2-oksokinolin-3-karboksamid eller et salt derav.Use of a quinoline-3-carboxamide compound for inflammatory bowel disease, comprising the structure (I) above, optionally with substituents for the hydrogen atoms (H1 "9) shown, or a pharmaceutically acceptable salt of the compound, wherein (a) ---- - means that there are two conjugated double bonds between the atoms, which bonds are represented by the dotted line; (b) X, and X2 are each independently selected from an oxygen atom and an NH9 group, where X and X2 are bonded to the ring by a single bond when connected to H7 or H8, and a double bond when not connected to H7 or H8; (c) H1 "9 each means a hydrogen atom, with the proviso that H9 occurs only when at least one of X , and X2 represents an NH9 group; (d) H7 and H8 each means a hydrogen atom associated with various atoms selected from X 1, X 2 and the nitrogen atom (N) of the quinoline ring, in the preparation of a composition for the treatment of inflammatory bowel disease or conditions associated with this disease. . Methods are also disclosed in the treatment of inflammatory bowel disease or conditions associated with this disease, in which methods the above compounds are administered to a living being. Particularly preferred compounds are N-phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide or a salt thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9400809A SE9400809D0 (en) | 1994-03-10 | 1994-03-10 | New use of quinoline-3-carboxamide compounds |
| PCT/SE1995/000244 WO1995024195A1 (en) | 1994-03-10 | 1995-03-08 | New use of quinoline-3-carboxamide compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO963764D0 NO963764D0 (en) | 1996-09-09 |
| NO963764L true NO963764L (en) | 1996-09-09 |
Family
ID=26661986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO963764A NO963764L (en) | 1994-03-10 | 1996-09-09 | New use of quinoline-3-carboxamide compounds |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO963764L (en) |
-
1996
- 1996-09-09 NO NO963764A patent/NO963764L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO963764D0 (en) | 1996-09-09 |
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