NO961748L - Polycyclic antiparasitic agents, process and strain for their preparation, and use thereof - Google Patents
Polycyclic antiparasitic agents, process and strain for their preparation, and use thereofInfo
- Publication number
- NO961748L NO961748L NO961748A NO961748A NO961748L NO 961748 L NO961748 L NO 961748L NO 961748 A NO961748 A NO 961748A NO 961748 A NO961748 A NO 961748A NO 961748 L NO961748 L NO 961748L
- Authority
- NO
- Norway
- Prior art keywords
- strain
- polycyclic
- preparation
- antiparasitic agents
- antiparasitic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
Abstract
There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/146,638 US5399582A (en) | 1993-11-01 | 1993-11-01 | Antiparasitic agents |
PCT/US1994/012302 WO1995012599A1 (en) | 1993-11-01 | 1994-10-27 | Polycyclic antiparasitic agents, process and strain for their preparation and their use |
Publications (3)
Publication Number | Publication Date |
---|---|
NO961748D0 NO961748D0 (en) | 1996-04-30 |
NO961748L true NO961748L (en) | 1996-07-01 |
NO315942B1 NO315942B1 (en) | 2003-11-17 |
Family
ID=22518283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19961748A NO315942B1 (en) | 1993-11-01 | 1996-04-30 | Polycyclic compounds, process for their preparation, use of the compounds for the preparation of a preparation for the treatment of animals infected with parasites, preparations which can be used for the treatment of parasite infection in animals, |
Country Status (24)
Country | Link |
---|---|
US (2) | US5399582A (en) |
EP (1) | EP0726902B1 (en) |
JP (1) | JP3557212B2 (en) |
KR (1) | KR100333017B1 (en) |
CN (2) | CN1046943C (en) |
AT (1) | ATE188476T1 (en) |
AU (1) | AU688405B2 (en) |
CA (1) | CA2174645C (en) |
CZ (1) | CZ286032B6 (en) |
DE (1) | DE69422526T2 (en) |
DK (1) | DK0726902T3 (en) |
ES (1) | ES2143558T3 (en) |
FI (2) | FI110871B (en) |
GR (1) | GR3032493T3 (en) |
HU (1) | HU221276B1 (en) |
NO (1) | NO315942B1 (en) |
NZ (1) | NZ275339A (en) |
PL (1) | PL178879B1 (en) |
PT (1) | PT726902E (en) |
RU (1) | RU2139874C1 (en) |
SI (1) | SI0726902T1 (en) |
SK (1) | SK281510B6 (en) |
WO (1) | WO1995012599A1 (en) |
ZA (1) | ZA948542B (en) |
Families Citing this family (74)
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US5399582A (en) * | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
US5541208A (en) * | 1994-01-24 | 1996-07-30 | Merck & Co., Inc. | Indole diterpene alkaloid compounds |
US5962499A (en) * | 1995-03-20 | 1999-10-05 | Merck & Co., Inc. | Nodulisporic acid derivatives |
US6221894B1 (en) | 1995-03-20 | 2001-04-24 | Merck & Co., Inc. | Nodulisporic acid derivatives |
ATE435648T1 (en) * | 1995-03-20 | 2009-07-15 | Merck & Co Inc | DERIVATIVES OF NODULISPOR ACID |
US5595991A (en) * | 1995-03-20 | 1997-01-21 | Merck & Co., Inc. | Anthelmintic use of nodulisporic acid and analogs thereof |
US5834260A (en) * | 1996-08-30 | 1998-11-10 | Merck & Co., Inc. | Antiparasitic agents |
AU712773B2 (en) * | 1996-09-19 | 1999-11-18 | Merck Sharp & Dohme Corp. | Nodulisporic acid derivatives |
AU1155499A (en) * | 1997-10-09 | 1999-05-03 | Rhone-Poulenc Agro | Pesticidal combination |
ES2359973T3 (en) * | 1998-03-19 | 2011-05-30 | MERCK SHARP & DOHME CORP. | LIQUID POLYMER COMPOSITIONS FOR THE CONTROLLED RELEASE OF BIOACTIVE SUBSTANCES. |
US6787342B2 (en) | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
US6399786B1 (en) * | 2000-07-14 | 2002-06-04 | Merck & Co., Inc. | Nonacyclic nodulisporic acid derivatives |
US6586452B1 (en) | 2000-07-14 | 2003-07-01 | Merck & Co., Inc. | C1 to C4 side chain modified nodulisporic acid analogs |
US20040077703A1 (en) * | 2002-10-02 | 2004-04-22 | Soll Mark D. | Nodulisporic acid derivative spot-on formulations for combating parasites |
US8362086B2 (en) | 2005-08-19 | 2013-01-29 | Merial Limited | Long acting injectable formulations |
NZ595260A (en) | 2006-07-05 | 2013-01-25 | Aventis Agriculture | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof |
DK3428148T3 (en) | 2007-05-15 | 2020-08-31 | Boehringer Ingelheim Animal Health Usa Inc | ARYLOAZOLE-2-YL-CYANOETHYLAMINO COMPOUNDS, METHOD OF MANUFACTURE AND METHOD OF USE |
TWI556741B (en) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | Isoxazoline compositions and their use as antiparasitics |
EP2237774B1 (en) | 2007-12-21 | 2016-06-22 | Merial Limited | THE USE OF 6-HALOGENO-(1,2,4)-TRIAZOLO-(1,5-a)-PYRIMIDINE COMPOUNDS FOR COMBATING PESTS IN AND ON ANIMALS |
HUE044046T2 (en) | 2008-11-14 | 2019-09-30 | Merial Inc | Enantiomerially enriched aryloazol-2-yl cyanoethylamino paraciticidal compounds |
WO2010059529A2 (en) | 2008-11-19 | 2010-05-27 | Merial Limited | Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof |
CA2745434C (en) | 2008-12-04 | 2017-06-20 | Merial Limited | Dimeric avermectin and milbemycin derivatives |
ES2545738T3 (en) | 2009-07-30 | 2015-09-15 | Merial, Inc. | Insecticidal compounds based on 4-amino-thieno [2,3-d] -pyrimidine and procedures for its use |
ES2546100T3 (en) | 2009-12-04 | 2015-09-18 | Merial, Inc. | Bis-organosulfurized pesticide compounds |
NZ600845A (en) | 2009-12-17 | 2014-08-29 | Merial Ltd | Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles |
ES2569486T3 (en) | 2009-12-17 | 2016-05-11 | Merial, Inc. | Antiparasitic dihydroazole compounds and compositions comprising the same |
US20120295931A1 (en) | 2010-02-05 | 2012-11-22 | Lutz Juergen | Spiroindoline compounds for use as anthelminthics |
UA108641C2 (en) | 2010-04-02 | 2015-05-25 | PARASITICID COMPOSITION CONTAINING FOUR ACTIVE AGENTS AND METHOD OF APPLICATION | |
EP2621903B1 (en) | 2010-09-29 | 2017-03-01 | Intervet International B.V. | N-heteroaryl compounds |
WO2012041872A1 (en) | 2010-09-29 | 2012-04-05 | Intervet International B.V. | N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases |
EP2640728B1 (en) | 2010-11-16 | 2016-09-07 | Merial, Inc. | Novel monensin derivatives for the treatment and prevention of protozoal infections |
JP2014520151A (en) | 2011-06-20 | 2014-08-21 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | Heterocyclic compounds for treating helminth infections |
EP2723716B1 (en) | 2011-06-27 | 2017-01-11 | Merial, Inc. | Amido-pyridyl ether compounds and compositions and their use against parasites |
WO2013003168A1 (en) | 2011-06-27 | 2013-01-03 | Merial Limited | Novel insect-repellent coumarin derivatives, syntheses, and methods of use |
WO2013017678A1 (en) | 2011-08-04 | 2013-02-07 | Intervet International B.V. | Novel spiroindoline compounds |
CR20180572A (en) | 2011-09-12 | 2019-02-01 | Merial Inc | PARASITICIDE COMPOSITIONS THAT INCLUDE AN ACTIVE AGENT OF ISOXAZOLINE, ITS METHODS AND USES (Divisional 2014-0117) |
US20130079394A1 (en) | 2011-09-23 | 2013-03-28 | Cnrs (Centre National Recherche Scientifique) | Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods |
EP2780008B1 (en) | 2011-11-17 | 2017-07-05 | Merial, Inc. | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof |
BR112014012759A8 (en) | 2011-11-28 | 2017-06-20 | Du Pont | compound, composition and method for treatment |
EP3351546B1 (en) | 2011-12-02 | 2024-02-14 | Boehringer Ingelheim Vetmedica GmbH | Long-acting injectable moxidectin formulations |
CN104168900A (en) | 2012-02-06 | 2014-11-26 | 梅里亚有限公司 | Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof |
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AR090545A1 (en) | 2012-03-28 | 2014-11-19 | Intervet Int Bv | HETEROARILO COMPOUND WITH AN ACICLIC BRIDGE UNIT |
PT2895465T (en) | 2012-04-20 | 2019-01-16 | Boehringer Ingelheim Animal Health Usa Inc | Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof |
SI2922845T1 (en) | 2012-11-20 | 2018-10-30 | Merial, Inc. | Anthelmintic compounds and compositions and method of using thereof |
WO2014099837A1 (en) | 2012-12-18 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Sulfonamide anthelmintics |
MX361516B (en) | 2013-11-01 | 2018-12-07 | Merial Inc | Antiparisitic and pesticidal isoxazoline compounds. |
US10857121B2 (en) | 2014-04-17 | 2020-12-08 | Merial Inc. | Use of malononitrile compounds for protecting animals from parasites |
CN106536518B (en) | 2014-05-19 | 2020-05-12 | 勃林格殷格翰动物保健美国公司 | Anthelmintic compounds |
WO2015196014A1 (en) | 2014-06-19 | 2015-12-23 | Merial, Inc. | Parasiticidal compositions comprising indole derivatives, methods and uses thereof |
US10864193B2 (en) | 2014-10-31 | 2020-12-15 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising fipronil at high concentrations |
UY36570A (en) | 2015-02-26 | 2016-10-31 | Merial Inc | INJECTABLE FORMULATIONS OF PROLONGED ACTION THAT INCLUDE AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES OF THE SAME |
LT3298027T (en) | 2015-05-20 | 2021-08-10 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
UY37137A (en) | 2016-02-24 | 2017-09-29 | Merial Inc | ANTIPARASITARY COMPOUNDS OF ISOXAZOLINE, INJECTABLE FORMULATIONS OF PROLONGED ACTION THAT INCLUDE THEM, METHODS AND USES OF THE SAME |
WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
US10653144B2 (en) | 2016-10-14 | 2020-05-19 | Boehringer Ingelheim Animal Health USA Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
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BR112020006214A2 (en) | 2017-09-29 | 2020-12-01 | Victoria Link Limited | heterologous biosynthesis of nodulisporic acids |
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AU2020404100A1 (en) | 2019-12-18 | 2022-06-09 | Intervet International B.V. | Anthelmintic compounds comprising azaindoles structure |
CA3183100A1 (en) | 2020-05-29 | 2021-12-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelmintic heterocyclic compounds |
CN116600807A (en) | 2020-12-11 | 2023-08-15 | 英特维特国际股份有限公司 | Insect repellent compound comprising thienopyridine structure |
CA3205997A1 (en) | 2020-12-21 | 2022-06-30 | University Of Georgia Research Foundation Inc. | Parasiticidal collar comprising isoxazoline compounds |
US20230312207A1 (en) | 2022-02-17 | 2023-10-05 | Boehringer Ingelheim Vetmedica Gmbh | Method and system for providing a fluid product mailer |
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SE434277B (en) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | SET TO MAKE NEW ANTIHELMINTICALLY EFFECTIVE ASSOCIATIONS BY CULTIVATING STREPTOMYCS AVERMITILIS |
US4199569A (en) * | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
DE3611168C2 (en) * | 1985-04-02 | 1994-01-20 | Asahi Chemical Ind | Hydroxybenzoesäurephenylester, their preparation and their use as physiologically active substances |
JP2805564B2 (en) * | 1992-08-13 | 1998-09-30 | 明治製菓株式会社 | New substance PF1101B substance and its manufacturing method |
US5399582A (en) * | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
-
1993
- 1993-11-01 US US08/146,638 patent/US5399582A/en not_active Expired - Lifetime
-
1994
- 1994-10-27 CZ CZ961249A patent/CZ286032B6/en not_active IP Right Cessation
- 1994-10-27 KR KR1019960702262A patent/KR100333017B1/en not_active IP Right Cessation
- 1994-10-27 AT AT94932063T patent/ATE188476T1/en active
- 1994-10-27 DE DE69422526T patent/DE69422526T2/en not_active Expired - Lifetime
- 1994-10-27 SI SI9430297T patent/SI0726902T1/en unknown
- 1994-10-27 SK SK539-96A patent/SK281510B6/en not_active IP Right Cessation
- 1994-10-27 EP EP94932063A patent/EP0726902B1/en not_active Expired - Lifetime
- 1994-10-27 RU RU96112175A patent/RU2139874C1/en active
- 1994-10-27 NZ NZ275339A patent/NZ275339A/en not_active IP Right Cessation
- 1994-10-27 JP JP51328695A patent/JP3557212B2/en not_active Expired - Lifetime
- 1994-10-27 DK DK94932063T patent/DK0726902T3/en active
- 1994-10-27 HU HU9601138A patent/HU221276B1/en unknown
- 1994-10-27 PT PT94932063T patent/PT726902E/en unknown
- 1994-10-27 CA CA002174645A patent/CA2174645C/en not_active Expired - Lifetime
- 1994-10-27 CN CN94194524A patent/CN1046943C/en not_active Expired - Lifetime
- 1994-10-27 ES ES94932063T patent/ES2143558T3/en not_active Expired - Lifetime
- 1994-10-27 AU AU80929/94A patent/AU688405B2/en not_active Expired
- 1994-10-27 PL PL94314190A patent/PL178879B1/en unknown
- 1994-10-27 WO PCT/US1994/012302 patent/WO1995012599A1/en active IP Right Grant
- 1994-10-31 ZA ZA948542A patent/ZA948542B/en unknown
- 1994-12-20 US US08/359,666 patent/US5614546A/en not_active Expired - Lifetime
-
1996
- 1996-04-30 FI FI961839A patent/FI110871B/en not_active IP Right Cessation
- 1996-04-30 NO NO19961748A patent/NO315942B1/en not_active IP Right Cessation
-
1999
- 1999-04-24 CN CN99106438A patent/CN1082543C/en not_active Expired - Lifetime
-
2000
- 2000-01-27 GR GR20000400187T patent/GR3032493T3/en unknown
-
2001
- 2001-11-27 FI FI20012318A patent/FI112503B/en not_active IP Right Cessation
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Legal Events
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MK1K | Patent expired |