NO960041L - Hemoregulatoriske penta- eller heksapeptider - Google Patents

Hemoregulatoriske penta- eller heksapeptider

Info

Publication number
NO960041L
NO960041L NO960041A NO960041A NO960041L NO 960041 L NO960041 L NO 960041L NO 960041 A NO960041 A NO 960041A NO 960041 A NO960041 A NO 960041A NO 960041 L NO960041 L NO 960041L
Authority
NO
Norway
Prior art keywords
hemoregulatory
hexapeptides
penta
compounds
myelopoietic
Prior art date
Application number
NO960041A
Other languages
English (en)
Other versions
NO960041D0 (no
Inventor
Erik Agner
Alan Cuthbertson
Peter Fischer
Pradip Bhatnagar
Mette Husbyn
Kjell Undheim
Original Assignee
Nycomed Pharma As
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Pharma As, Smithkline Beecham Corp filed Critical Nycomed Pharma As
Publication of NO960041D0 publication Critical patent/NO960041D0/no
Publication of NO960041L publication Critical patent/NO960041L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C07K7/067—Hemoregulatory peptides based on sequence Glp-Glu-Asp-Cys-Lys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Denne oppfinnelsen relaterer til peptidforbindelser som omfatter to monomere peptider med regulatorisk celleproliferings-aktivitet, knyttet sammen med to eller flere divalente brokoblingsenheter. Slike forbindelser har en stimulerende effekt på celledeling, spesielt for 1 myelopoese- og beinmargsceller.I. Peptidforbindelsene med regulatorsik celleproliferasjon aktivitet har formlene I. n eller III. hvor j A, og A,, som er like ete forskjeUige, representererI! hverkan uavhengig av hverandre være pyroglutaminsyre (p-Glu). picolinsyre (Pic), 3-hydroksypicolinsyre (30H-Pic). prolin. N-acetyl-prolin. pyrazinkarboksylsyre. pyrazindikarboksylsyre. nikotinsyre. isonikotinsyre. pipekolinsyre. pyrrolkarboksylsyre. antranilsyre. kinolinkarboksylsyre. isokinolinkarboksylsyre. turahkarboksylsyre, ortinsyre. eller pyraiolkarboksylsyre; 1 hver R» kan uavhengig av hverandre være «rin (Ser), gutaminsyre (Glu), \ uparagu«yre(Mp).treoiun(Trj)eneralloueordn(aThr); hver R' kan uavhengig være asparaginsyre (Mp), glutaminsyre (Glu), eller cystin(Cys); R' kan uavhengig være lysin (Lys), ortinin (Om) eller cystin (Cys); r og s kan begge være 0 eller 1; t og u kan begge være 0 eller 1 men minst en av t og u ml være 1; hver gruppe B representerer den bindende sidekjeden til Rog R' slik at (a) hver gruppe B kan uavhengig representere -(CHJ.-CONH-<CH)-, hvor v er 1 eller 2, og w er 3 eller 4, forutsatt at det i pepudkjeden hvor gruppe B er tilknyttet er RAsp eller Glu og R' er Lys eller Orn; eller (b) hver gruppe B kan uavhengig representere -CH,-S-S-CH,-, hvor Rog R' i peptidkjeden hvor gruppe B er tilknyttet, begge er Cys;. hver R kan uavhengig av hverandre være hydrogen eller metyl; og hver Rkan være en gruppe -OH eller NH„ og saltene derav.Søknaden omhandler også fremgangsmåte for fremstilling av de angitte forbindelser og mellomprodukter.
NO960041A 1993-07-09 1996-01-04 Hemoregulatoriske penta- eller heksapeptider NO960041L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939314200A GB9314200D0 (en) 1993-07-09 1993-07-09 Peptide compounds
PCT/GB1994/001501 WO1995001990A1 (en) 1993-07-09 1994-07-11 Hemoregulatory penta- or hexapeptides

Publications (2)

Publication Number Publication Date
NO960041D0 NO960041D0 (no) 1996-01-04
NO960041L true NO960041L (no) 1996-01-04

Family

ID=10738530

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960041A NO960041L (no) 1993-07-09 1996-01-04 Hemoregulatoriske penta- eller heksapeptider

Country Status (10)

Country Link
EP (1) EP0722459B1 (no)
JP (1) JPH08512310A (no)
AT (1) ATE174927T1 (no)
AU (1) AU7129694A (no)
DE (1) DE69415548D1 (no)
EE (1) EE9400051A (no)
GB (1) GB9314200D0 (no)
NO (1) NO960041L (no)
WO (1) WO1995001990A1 (no)
ZA (1) ZA945006B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9425730D0 (en) * 1994-12-20 1995-02-22 Nycomed Pharma As Compounds
JP2010520238A (ja) 2007-03-01 2010-06-10 マリンクロット インコーポレイテッド 統合された光活性低分子および統合された光活性低分子使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8626539D0 (en) * 1986-11-06 1986-12-10 Nycomed As Peptide compounds
ZW11290A1 (en) * 1989-07-14 1990-10-31 Smithkline Beecham Corp Hemoregulatory peptides

Also Published As

Publication number Publication date
JPH08512310A (ja) 1996-12-24
ATE174927T1 (de) 1999-01-15
NO960041D0 (no) 1996-01-04
DE69415548D1 (de) 1999-02-04
AU7129694A (en) 1995-02-06
GB9314200D0 (en) 1993-08-18
WO1995001990A1 (en) 1995-01-19
EP0722459B1 (en) 1998-12-23
EP0722459A1 (en) 1996-07-24
ZA945006B (en) 1995-02-21
EE9400051A (et) 1995-12-15

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