NO955067L - FVII / TF peptides - Google Patents

FVII / TF peptides

Info

Publication number
NO955067L
NO955067L NO955067A NO955067A NO955067L NO 955067 L NO955067 L NO 955067L NO 955067 A NO955067 A NO 955067A NO 955067 A NO955067 A NO 955067A NO 955067 L NO955067 L NO 955067L
Authority
NO
Norway
Prior art keywords
pct
date
sec
fvii
peptides
Prior art date
Application number
NO955067A
Other languages
Norwegian (no)
Other versions
NO955067D0 (en
Inventor
Ross W Stephens
Lars Orning
Kjell Steinar Sakariassen
Original Assignee
Nycomed Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939312601A external-priority patent/GB9312601D0/en
Application filed by Nycomed Pharma As filed Critical Nycomed Pharma As
Publication of NO955067D0 publication Critical patent/NO955067D0/en
Publication of NO955067L publication Critical patent/NO955067L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PCT No. PCT/GB94/01315 Sec. 371 Date May 28, 1996 Sec. 102(e) Date May 28, 1996 PCT Filed Jun. 17, 1994 PCT Pub. No. WO95/00541 PCT Pub. Date Jan. 5, 1995The present invention relates to compounds comprising the amino acid sequences of the formulae (IA): -CVNENGGCEQYCSD-, (IB): -FCLPAFEGRNCE- and/or (IC): -RCHEGYSLLADGVSCT- as well as peptide fragments thereof, esters, amides, salts and cyclic derivatives thereof, functional analogues thereof and extended peptide chains carrying amino acids or peptides at the termini of the above sequences or fragments, for use in the prevention or inhibition of binding of tissue factor to FVII.
NO955067A 1993-06-18 1995-12-14 FVII / TF peptides NO955067L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939312601A GB9312601D0 (en) 1993-06-18 1993-06-18 Peptides
GB9409335A GB9409335D0 (en) 1993-06-18 1994-05-10 Peptides
PCT/GB1994/001315 WO1995000541A1 (en) 1993-06-18 1994-06-17 Factor vii-derived peptides

Publications (2)

Publication Number Publication Date
NO955067D0 NO955067D0 (en) 1995-12-14
NO955067L true NO955067L (en) 1995-12-14

Family

ID=26303086

Family Applications (1)

Application Number Title Priority Date Filing Date
NO955067A NO955067L (en) 1993-06-18 1995-12-14 FVII / TF peptides

Country Status (15)

Country Link
US (1) US5962418A (en)
EP (1) EP0703923B1 (en)
JP (1) JPH08511794A (en)
CN (1) CN1125450A (en)
AT (1) ATE171950T1 (en)
CA (1) CA2164422A1 (en)
CZ (1) CZ334095A3 (en)
DE (1) DE69413817T2 (en)
DK (1) DK0703923T3 (en)
FI (1) FI956055A (en)
HU (1) HUT74873A (en)
NO (1) NO955067L (en)
NZ (1) NZ267453A (en)
SK (1) SK156395A3 (en)
WO (1) WO1995000541A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652332A (en) * 1993-03-12 1997-07-29 Xoma Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
GB9425380D0 (en) * 1994-12-15 1995-02-15 Nycomed Pharma As Peptides
GB9425381D0 (en) * 1994-12-15 1995-02-15 Nycomed Pharma As Peptides
US5837684A (en) * 1995-06-07 1998-11-17 Nycomed Imaging As Peptides
WO1999013062A1 (en) * 1997-09-09 1999-03-18 Nycomed Imaging As Factors vii fragments and analogs thereof and their use in the treatment of blood clotting disorders
WO1999013063A1 (en) * 1997-09-09 1999-03-18 Nycomed Imaging As Factor vii fragments and analogs thereof and their use in the treatment of blood clottng disorders
EP0987274A1 (en) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors
AU5062100A (en) * 1999-06-14 2001-01-02 Novo Nordisk A/S Fviia/tf activity inhibiting compounds
WO2001001749A2 (en) 1999-07-02 2001-01-11 Genentech, Inc. FVIIa ANTAGONISTS
US7164002B2 (en) 2002-02-06 2007-01-16 Genentech, Inc. FVIIa antagonists
US20060257359A1 (en) * 2005-02-28 2006-11-16 Cedric Francois Modifying macrophage phenotype for treatment of disease
WO2017121436A1 (en) 2016-01-15 2017-07-20 Rigshospitalet Quantitative pet imaging of tissue factor expression using 18f-labled active site inhibited factor vii
US20190358351A1 (en) 2016-11-17 2019-11-28 Minerva Imaging Aps 177-lu labeled active site inhibited factor vii

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
US4772587A (en) * 1985-04-16 1988-09-20 Suntory Limited Dipeptide derivative of fatty acid
US5087564A (en) * 1985-06-20 1992-02-11 Monsanto Company Release of recombinant peptides from polypeptides using V8 endopeptidase
US5047401A (en) * 1985-09-09 1991-09-10 Board Of Regents, The University Of Texas System Use of dipeptide alkyl esters to treat GVHD
EP0391999A4 (en) * 1988-09-23 1991-03-13 Corvas, Inc. Peptidyl inhibitors of the initiation of coagulation
JP3330932B2 (en) * 1990-01-29 2002-10-07 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Anticoagulant protein
DE4007902A1 (en) * 1990-03-13 1991-09-19 Behringwerke Ag SYNTHETIC PEPTIDES CONTAINING SEQUENCES OF FACTOR VIIA AND ITS USE
CA2042295A1 (en) * 1990-05-15 1991-11-16 Jacques Chauveau Endogen mediator derivatives, salts thereof, process for their preparation, applications and compositions containing such
WO1993009804A1 (en) * 1991-11-18 1993-05-27 The Scripps Research Institute Serine protease derived-polypeptides and anti-peptide antibodies, systems and therapeutic methods for inhibiting coagulation

Also Published As

Publication number Publication date
EP0703923B1 (en) 1998-10-07
FI956055A0 (en) 1995-12-15
SK156395A3 (en) 1996-06-05
CN1125450A (en) 1996-06-26
NO955067D0 (en) 1995-12-14
WO1995000541A1 (en) 1995-01-05
DE69413817T2 (en) 1999-06-10
AU6975594A (en) 1995-01-17
NZ267453A (en) 1997-03-24
AU691814B2 (en) 1998-05-28
US5962418A (en) 1999-10-05
CA2164422A1 (en) 1995-01-05
DK0703923T3 (en) 1999-06-21
ATE171950T1 (en) 1998-10-15
DE69413817D1 (en) 1998-11-12
CZ334095A3 (en) 1996-07-17
HUT74873A (en) 1997-02-28
EP0703923A1 (en) 1996-04-03
JPH08511794A (en) 1996-12-10
FI956055A (en) 1996-01-26
HU9503593D0 (en) 1996-02-28

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application