NO954739L - Substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and drugs containing these compounds - Google Patents

Substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and drugs containing these compounds

Info

Publication number
NO954739L
NO954739L NO954739A NO954739A NO954739L NO 954739 L NO954739 L NO 954739L NO 954739 A NO954739 A NO 954739A NO 954739 A NO954739 A NO 954739A NO 954739 L NO954739 L NO 954739L
Authority
NO
Norway
Prior art keywords
diagnostic
drug
compounds
processes
preparation
Prior art date
Application number
NO954739A
Other languages
Norwegian (no)
Other versions
NO954739D0 (en
Inventor
Jan-Robert Schwark
Heinz-Werner Kleemann
Hans-Jochen Lang
Andreas Weichert
Wolfgang Scholz
Udo Albus
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO954739D0 publication Critical patent/NO954739D0/en
Publication of NO954739L publication Critical patent/NO954739L/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Det er beskrevet benzoylguanidiner med formel (I) hvori R(l) betyr R(6)-CO eller R(7)R(8)N-CO, med R(2) definert som R(l), eller l betydningen H, OH, Hal, CN, N02, (pernuor)alk(en)yl, -(CH)2R(15), eller R(2) betyr (Cj-CgJ-heteroaryl, eller R(2) betyr SR(18), -OR(18). -NR(18)R(19). -CR(18)R(19)R(20); eller (R2) betyr R(21-S0n, eller R(22)R(23)N-S02-, eller R(2) betyr R(33)X-, hvorved X betyr oksygen, S, NR(34), (D-O)A-, NR(34)OMN(I<)R(35)-, eller R(2) betyr -SR(40), -OR(40), NHR(40), -NR(40)R(41), -CHR(40)R(42), -CR(42)R(43)OH, -C=CR(45), -CR(46)-CR(45) eller-[CR(47)R(48)]U-CO-[CR(49)R(50)]V-R(44); eller i R(2) betyr R(55)-HH-S02-, R(3), R(4) og R(5) er uavhengig av hverandre definert som R(l) eller R(2), ! hvorved imidlertid minst en av substltuentene R(2), R(3), R(4) og R(5) må være Ilk OH; samt deres farmasøytisk godtagbare salter.Benzoylguanidines of formula (I) are described in which R (1) means R (6) -CO or R (7) R (8) N-CO, with R (2) defined as R (1), or in the meaning of H , OH, Hal, CN, NO2, (pernu) alk (en) yl, - (CH) 2R (15), or R (2) means (C1-C8J heteroaryl, or R (2) means SR (18) , -OR (18), -NR (18) R (19), -CR (18) R (19) R (20), or (R 2) means R (21-Son, or R (22) R (23) ) N-SO 2 - or R (2) means R (33) X-, where X means oxygen, S, NR (34), (DO) A, NR (34) OMN (I <) R (35) -, or R (2) means -SR (40), -OR (40), NHR (40), -NR (40) R (41), -CHR (40) R (42), -CR (42) R (43) OH, -C = CR (45), -CR (46) -CR (45) or- [CR (47) R (48)] U-CO- [CR (49) R (50)] VR (44) or in R (2) means R (55) -HH-SO 2 -, R (3), R (4) and R (5) are independently defined as R (1) or R (2) however, whereby at least one of the substituents R (2), R (3), R (4) and R (5) must be Ilk OH, as well as their pharmaceutically acceptable salts.

NO954739A 1994-11-24 1995-11-23 Substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and drugs containing these compounds NO954739L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4441880A DE4441880A1 (en) 1994-11-24 1994-11-24 Substituted benzoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Publications (2)

Publication Number Publication Date
NO954739D0 NO954739D0 (en) 1995-11-23
NO954739L true NO954739L (en) 1996-05-28

Family

ID=6534070

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954739A NO954739L (en) 1994-11-24 1995-11-23 Substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and drugs containing these compounds

Country Status (18)

Country Link
EP (1) EP0713864A1 (en)
JP (1) JPH08225514A (en)
KR (1) KR960017628A (en)
CN (1) CN1132745A (en)
AU (1) AU3900895A (en)
BR (1) BR9505295A (en)
CA (1) CA2163598A1 (en)
CZ (1) CZ308495A3 (en)
DE (1) DE4441880A1 (en)
FI (1) FI955614A (en)
HR (1) HRP950570A2 (en)
HU (1) HUT73789A (en)
IL (1) IL116096A0 (en)
NO (1) NO954739L (en)
NZ (1) NZ280517A (en)
PL (1) PL311467A1 (en)
SI (1) SI9500362A (en)
ZA (1) ZA959972B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0765867A1 (en) * 1995-09-27 1997-04-02 Hoechst Aktiengesellschaft Substituted benzoyl guanidines, process for their preparation, their use as antiarrhythmics or diagnostic agent as well as pharmaceuticals containing them
DE19540995A1 (en) * 1995-11-03 1997-05-07 Hoechst Ag Substituted sulfonimidamides, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
DE19542306A1 (en) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (en) * 1995-12-14 1997-06-19 Hoechst Ag Substituted chromanylsulfonyl (thio) ureas, process for their preparation and their use in the manufacture of pharmaceutical preparations
DE19738604A1 (en) * 1997-09-04 1999-03-11 Hoechst Marion Roussel De Gmbh Use of Na<+>/H<+> exchange inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE158278T1 (en) * 1992-02-15 1997-10-15 Hoechst Ag ORTHO-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICATION OR DIAGNOSTIC AND A MEDICINE CONTAINING THEM
CZ284456B6 (en) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Amino substituted benzylguanidines, process of their preparation and their use for preparing medicaments
ATE157351T1 (en) * 1993-02-20 1997-09-15 Hoechst Ag SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICATION, AS INHIBITORS OF CELLULAR NA+/H+ EXCHANGE OR AS A DIAGNOSTIC, AND MEDICINE CONTAINING THEM
DE4318756A1 (en) * 1993-06-05 1994-12-08 Hoechst Ag Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them

Also Published As

Publication number Publication date
FI955614A (en) 1996-05-25
PL311467A1 (en) 1996-05-27
SI9500362A (en) 1996-06-30
BR9505295A (en) 1997-10-21
HUT73789A (en) 1996-09-30
IL116096A0 (en) 1996-01-31
CZ308495A3 (en) 1996-06-12
FI955614A0 (en) 1995-11-22
EP0713864A1 (en) 1996-05-29
CA2163598A1 (en) 1996-05-25
KR960017628A (en) 1996-06-17
ZA959972B (en) 1996-06-04
CN1132745A (en) 1996-10-09
NZ280517A (en) 1996-09-25
DE4441880A1 (en) 1996-05-30
HRP950570A2 (en) 1997-08-31
AU3900895A (en) 1996-05-30
HU9503345D0 (en) 1996-01-29
NO954739D0 (en) 1995-11-23
JPH08225514A (en) 1996-09-03

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