NO953067L - Expression of protective antigens - Google Patents
Expression of protective antigensInfo
- Publication number
- NO953067L NO953067L NO953067A NO953067A NO953067L NO 953067 L NO953067 L NO 953067L NO 953067 A NO953067 A NO 953067A NO 953067 A NO953067 A NO 953067A NO 953067 L NO953067 L NO 953067L
- Authority
- NO
- Norway
- Prior art keywords
- fragment
- antigen
- enzyme
- expression
- integration
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Denne oppfinnelse tilveiebringer en fremgangsmåte for ekspresjon av et enzymantigen som i naturen er et parasitt- tarmmembranbundet eller et fragment derav som har lignende enzym- og/eller antigen-aktivitet, hvori pattedyrvertsceller blir transfektert med en vektor tilpasset til å uttrykke nevnte enzymantigen eller fragment derav, karakterisert ved at vertscellene før transformasjon er i alt vesentlig fri for endogene enzymer som har (a) den samme funksjon og (b) den samme cellemembranintegrasjon eller mangel på integrasjon, som nevnte parasittenzymantigen eller fragment derav. En slik fremgangsmåte er særlig anvendelig for ekspresjon av integrale membranaminopeptidaseantigener fra innvollsormer.This invention provides a method for expressing an enzyme antigen which is by nature a parasitic intestinal membrane bound or a fragment thereof having similar enzyme and / or antigen activity, wherein mammalian host cells are transfected with a vector adapted to express said enzyme antigen or fragment thereof. , characterized in that the host cells prior to transformation are substantially free of endogenous enzymes having (a) the same function and (b) the same cell membrane integration or lack of integration, as said parasite enzyme antigen or fragment thereof. Such a method is particularly useful for expression of integral membrane aminopeptidase antigens from intestinal worms.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939302302A GB9302302D0 (en) | 1993-02-05 | 1993-02-05 | Process |
| PCT/GB1994/000204 WO1994018320A1 (en) | 1993-02-05 | 1994-02-04 | Expression of protective antigens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO953067D0 NO953067D0 (en) | 1995-08-04 |
| NO953067L true NO953067L (en) | 1995-10-04 |
Family
ID=10729928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO953067A NO953067L (en) | 1993-02-05 | 1995-08-04 | Expression of protective antigens |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0682702A1 (en) |
| JP (1) | JPH08506726A (en) |
| AU (1) | AU682488B2 (en) |
| BG (1) | BG61574B1 (en) |
| BR (1) | BR9406442A (en) |
| CA (1) | CA2155120A1 (en) |
| CZ (1) | CZ285042B6 (en) |
| FI (1) | FI953682A (en) |
| GB (1) | GB9302302D0 (en) |
| HU (1) | HU219539B (en) |
| NO (1) | NO953067L (en) |
| NZ (1) | NZ261144A (en) |
| PL (1) | PL178330B1 (en) |
| RU (1) | RU2126045C1 (en) |
| UA (1) | UA32437C2 (en) |
| WO (1) | WO1994018320A1 (en) |
| ZA (1) | ZA94740B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9209993D0 (en) * | 1992-05-08 | 1992-06-24 | Munn Edward A | Vaccines |
| GB9322702D0 (en) | 1993-11-03 | 1993-12-22 | Agricultural & Food Res | Vaccines |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8619293D0 (en) * | 1986-08-07 | 1986-09-17 | Munn E A | Anthelmintic agents |
| GB8906156D0 (en) * | 1989-03-17 | 1989-05-04 | Munn Edward A | Production and use of anthelmintic agents and protective immunogens |
| JP2700088B2 (en) * | 1991-07-25 | 1998-01-19 | 房則 濱島 | Immunosuppressants |
| GB9209993D0 (en) * | 1992-05-08 | 1992-06-24 | Munn Edward A | Vaccines |
| GB9322702D0 (en) * | 1993-11-03 | 1993-12-22 | Agricultural & Food Res | Vaccines |
-
1993
- 1993-02-05 GB GB939302302A patent/GB9302302D0/en active Pending
-
1994
- 1994-02-03 ZA ZA94740A patent/ZA94740B/en unknown
- 1994-02-04 WO PCT/GB1994/000204 patent/WO1994018320A1/en not_active Application Discontinuation
- 1994-02-04 BR BR9406442A patent/BR9406442A/en not_active Application Discontinuation
- 1994-02-04 PL PL94310109A patent/PL178330B1/en unknown
- 1994-02-04 CA CA002155120A patent/CA2155120A1/en not_active Abandoned
- 1994-02-04 HU HU9502311A patent/HU219539B/en not_active IP Right Cessation
- 1994-02-04 JP JP6517779A patent/JPH08506726A/en active Pending
- 1994-02-04 AU AU59753/94A patent/AU682488B2/en not_active Ceased
- 1994-02-04 UA UA95083782A patent/UA32437C2/en unknown
- 1994-02-04 EP EP94905785A patent/EP0682702A1/en not_active Withdrawn
- 1994-02-04 NZ NZ261144A patent/NZ261144A/en unknown
- 1994-02-04 CZ CZ951994A patent/CZ285042B6/en not_active IP Right Cessation
- 1994-02-04 RU RU95120188A patent/RU2126045C1/en active
-
1995
- 1995-08-02 FI FI953682A patent/FI953682A/en unknown
- 1995-08-04 NO NO953067A patent/NO953067L/en not_active Application Discontinuation
- 1995-08-28 BG BG99887A patent/BG61574B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9406442A (en) | 1996-02-27 |
| PL310109A1 (en) | 1995-11-27 |
| AU682488B2 (en) | 1997-10-09 |
| NO953067D0 (en) | 1995-08-04 |
| NZ261144A (en) | 1998-02-26 |
| FI953682A0 (en) | 1995-08-02 |
| UA32437C2 (en) | 2000-12-15 |
| CZ199495A3 (en) | 1996-02-14 |
| PL178330B1 (en) | 2000-04-28 |
| CZ285042B6 (en) | 1999-05-12 |
| JPH08506726A (en) | 1996-07-23 |
| HUT72990A (en) | 1996-06-28 |
| RU2126045C1 (en) | 1999-02-10 |
| CA2155120A1 (en) | 1994-08-18 |
| HU9502311D0 (en) | 1995-10-30 |
| GB9302302D0 (en) | 1993-03-24 |
| EP0682702A1 (en) | 1995-11-22 |
| BG99887A (en) | 1996-12-31 |
| FI953682A (en) | 1995-08-02 |
| WO1994018320A1 (en) | 1994-08-18 |
| HU219539B (en) | 2001-05-28 |
| BG61574B1 (en) | 1997-12-30 |
| AU5975394A (en) | 1994-08-29 |
| ZA94740B (en) | 1994-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Manoury et al. | An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation | |
| Zito et al. | Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin | |
| Millar et al. | Mitochondrial cytochrome c oxidase and succinate dehydrogenase complexes contain plant specific subunits | |
| Hehemann et al. | Bacteria of the human gut microbiome catabolize red seaweed glycans with carbohydrate-active enzyme updates from extrinsic microbes | |
| Charlab et al. | Toward an understanding of the biochemical and pharmacological complexity of the saliva of a hematophagous sand fly Lutzomyia longipalpis | |
| MX9606476A (en) | The cytoplasmic inhibition of gene expression. | |
| Klein et al. | Pineal Serotonin N-Acetyltransferase Activity: Abrupt Decrease in Adenosine 3′, 5′-Monophosphate May Be Signal for" Turnoff" | |
| NO20050935L (en) | BMP-2 estrogen responsive element and methods for using the same | |
| GB9703406D0 (en) | Expression of heterologous proteins | |
| SG141233A1 (en) | Control of gene expression | |
| DE69534227D1 (en) | SUBSTANCES AND METHODS FOR CONTROLLING THE HYPERACOUS EXTRACTION OF HUMAN TRANSPLANTS | |
| MXPA02006145A (en) | Method for isolation of rna from formalinfixed paraffinembedded tissue specimens. | |
| NO20050447L (en) | Isolation and identification of T cells | |
| Mourão et al. | Role of the endogenous antioxidant system in the protection of Schistosoma mansoni primary sporocysts against exogenous oxidative stress | |
| Isaac et al. | Insect angiotensin‐converting enzyme: a processing enzyme with broad substrate specificity and a role in reproduction | |
| Yi et al. | Purification of progenitors from skeletal muscle | |
| Li et al. | Comparative analysis of iTRAQ-based proteome profiles of Schistosoma japonicum female worms coming from single-sex infections and bisexual infections | |
| Liu et al. | Generation of Plasmodium yoelii malaria parasite for conditional degradation of proteins | |
| Villar et al. | Expression of heat shock and other stress response proteins in ticks and cultured tick cells in response to Anaplasma spp. infection and heat shock | |
| NO953067L (en) | Expression of protective antigens | |
| David et al. | Isoaspartate in ribosomal protein S11 of Escherichia coli | |
| AU2002361797A1 (en) | Cell lines with latent immunodeficiency virus and methods of use thereof | |
| Djuika et al. | Prokaryotic ancestry and gene fusion of a dual localized peroxiredoxin in malaria parasites | |
| Isawa et al. | Construction of an infectious cDNA clone of Culex flavivirus, an insect-specific flavivirus from Culex mosquitoes | |
| Wright et al. | Cell-type control of membrane biogenesis induced by HMG-CoA reductase. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |