NO952800L - Fremgangsmåter for forhindring av progressiv vevsnekrose, reperfusjonsskade, bakteriell translokasjon og akutt lungesviktsyndrom hos voksne - Google Patents

Fremgangsmåter for forhindring av progressiv vevsnekrose, reperfusjonsskade, bakteriell translokasjon og akutt lungesviktsyndrom hos voksne

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Publication number
NO952800L
NO952800L NO952800A NO952800A NO952800L NO 952800 L NO952800 L NO 952800L NO 952800 A NO952800 A NO 952800A NO 952800 A NO952800 A NO 952800A NO 952800 L NO952800 L NO 952800L
Authority
NO
Norway
Prior art keywords
dhea
pct
derivatives
bacterial translocation
patient
Prior art date
Application number
NO952800A
Other languages
English (en)
Other versions
NO952800D0 (no
Inventor
Raymond A Daynes
Barbara A Araneo
Original Assignee
Univ Utah Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah Res Found filed Critical Univ Utah Res Found
Publication of NO952800D0 publication Critical patent/NO952800D0/no
Publication of NO952800L publication Critical patent/NO952800L/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Foreliggende oppfinnelse er rettet mot en fremgangsmåte for å forhindre eller redusere ischemi etter skade, som f.eks. reperfusjonsskade etter ischemi, cellulsr ødeleggelse assosiert med ischemiske episoder, som infarktasjoner eller traumatiske skader, og således forhindre eller redusere den påfølgende progressive nekrose av vev som er assosiert med ischemien. Denne effekt oppnås ved å administrere DHEA eller DHEA-derivater til en pasient så snart som mulig etter skaden. Foreliggende oppfinnelse er videre rettet mot 'fremgangsmåter for å forhindre eller redusere bakteriell translokasjon ved ARDS (adult respiratory distress syndrome) hos en pasient. Likeledes forhindres eller reduseres bakteriell translokasjon og ARDS ved å administrere DHEA eller DHEA-derivater til en pasient. Egnede derivater av DHEA er blant annet 16a-brom- DHEA, androstendiol og derivater som har sidekjeder i 4'- og/eller 7'-stillingene og som ikke ødelegger den naturlige aktivitet av DHEA, men som er i stand til å inhibere sulfotransferase for å hindre omdannelsen av DHEA til DHEA-S.
NO952800A 1993-03-09 1995-07-14 Fremgangsmåter for forhindring av progressiv vevsnekrose, reperfusjonsskade, bakteriell translokasjon og akutt lungesviktsyndrom hos voksne NO952800L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2942293A 1993-03-09 1993-03-09
PCT/US1994/002558 WO1994020111A1 (en) 1993-03-09 1994-03-08 Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome

Publications (2)

Publication Number Publication Date
NO952800D0 NO952800D0 (no) 1995-07-14
NO952800L true NO952800L (no) 1995-09-14

Family

ID=21848945

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952800A NO952800L (no) 1993-03-09 1995-07-14 Fremgangsmåter for forhindring av progressiv vevsnekrose, reperfusjonsskade, bakteriell translokasjon og akutt lungesviktsyndrom hos voksne

Country Status (15)

Country Link
US (3) US5532230A (no)
EP (1) EP0688220B1 (no)
JP (1) JP2858046B2 (no)
KR (1) KR960700728A (no)
AT (1) ATE283052T1 (no)
AU (3) AU677308B2 (no)
CA (1) CA2153895A1 (no)
CZ (1) CZ193495A3 (no)
DE (1) DE69434149T2 (no)
ES (1) ES2229215T3 (no)
FI (1) FI953814A (no)
HU (1) HUT72968A (no)
NO (1) NO952800L (no)
SK (1) SK103195A3 (no)
WO (1) WO1994020111A1 (no)

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Also Published As

Publication number Publication date
JPH08507531A (ja) 1996-08-13
ATE283052T1 (de) 2004-12-15
FI953814A0 (fi) 1995-08-11
AU2013297A (en) 1997-07-10
DE69434149T2 (de) 2006-07-20
US5489581A (en) 1996-02-06
AU2013197A (en) 1997-07-10
DE69434149D1 (de) 2004-12-30
CA2153895A1 (en) 1994-09-15
US5583126A (en) 1996-12-10
AU677308B2 (en) 1997-04-17
ES2229215T3 (es) 2005-04-16
AU6400794A (en) 1994-09-26
WO1994020111A1 (en) 1994-09-15
HUT72968A (en) 1996-06-28
FI953814A (fi) 1995-11-07
EP0688220B1 (en) 2004-11-24
US5532230A (en) 1996-07-02
KR960700728A (ko) 1996-02-24
AU687704B2 (en) 1998-02-26
AU691776B2 (en) 1998-05-21
HU9502126D0 (en) 1995-09-28
EP0688220A1 (en) 1995-12-27
CZ193495A3 (en) 1996-04-17
SK103195A3 (en) 1996-12-04
EP0688220A4 (en) 1998-04-01
JP2858046B2 (ja) 1999-02-17
NO952800D0 (no) 1995-07-14

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Alemany Andrés Combalía, MD, PhD Orthopaedic Staff Associate Professor