NO952465L - Process for Preparation of Aryl-Condensed and Heteraryl-Condensed-2,4-Diazepine and 2,4-Diazocin Compounds - Google Patents

Process for Preparation of Aryl-Condensed and Heteraryl-Condensed-2,4-Diazepine and 2,4-Diazocin Compounds

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Publication number
NO952465L
NO952465L NO952465A NO952465A NO952465L NO 952465 L NO952465 L NO 952465L NO 952465 A NO952465 A NO 952465A NO 952465 A NO952465 A NO 952465A NO 952465 L NO952465 L NO 952465L
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NO
Norway
Prior art keywords
lower alkyl
phenyl
benzyl
halogen
lower alkoxy
Prior art date
Application number
NO952465A
Other languages
Norwegian (no)
Other versions
NO952465D0 (en
Inventor
Robert Ed Johnson
Donald Charles Schlegel
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NO913566A external-priority patent/NO300268B1/en
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Priority to NO952465A priority Critical patent/NO952465L/en
Publication of NO952465D0 publication Critical patent/NO952465D0/en
Publication of NO952465L publication Critical patent/NO952465L/en

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Aryl-kondensert- og hetaryH{andensert-2,4-diazeplner og -dlazoclner av de generelle formler: R» .-«*¿ R" R»' eller (XXXa) samt aryldlretanardner av formler: (Ha) (Via) (VTb) (IVa) hvor R1 er hydrogen, laverealkyl, benzyl, naftyl, tlenyl, pyridlnyl, fenyl, eller fenyl son har en eller to substltuenter valgt fra laverealkyl og lavere- alkoksy; R2 er hydrogen; laverealkyl; benzyl; fenyl; fenyl substituert med halogen, laverealkyl eller laverealkoksy; eller R2 er -OtøCHgR7, hvor R7 er laverealkoksy, benzyl, dl-( laverealkyl )amlno, pyrrolidlno, piperldlno, morfollno, fenyl, eller fenyl substituert med amlno, nltro eller lavereallqrlsulfonanido: R2" er hydrogen; lavereallgrl; dl(laverealKyl)aminoalXyl: benzyl; fenyl; fenetyl eller fenyl substituert med halogen, laverealkyl eller laverealkoksy; R33 er (YaL-(CH2)m-(Xa)n-R8, hvor Ya, p. m, n & og R8 har forskjellige betydninger; R5er hydrogen; laverealkyl; naftyl; tienyl; pyridinyl; benzyl; fenyl; eller fenyl son har en eller to substituanter valgt fra laverealkyl, laverealkoksy, halogen, hydroksyl, amlno, dl(laverealkyl )amino, laverealkylsulfmamido og lavereacylamlno; R¿ er hydrogen; laverealkyl: naftyl; tienyl; pyrldlnyl; benzyl; fenyl; eller fenyl som har en eller to substituenter valgt fra laverealtyl, laverealkcksy og halogen; R50 er laverealkyl: fenyl; naftyl; tienyl; pyrldlnyl: benzyl: eller fenyl son har en eller to substltuenter valgt fra laverealkyl, laverealkoksy og halogen; R6 er en eller to substituenter valgt uavhengig fra gruppen bestående av hydrogen, laverealkyl, laverealkoksy, halogen; nltro og laverealkylsulfonamido eller R° er en kondensert benzenrlng; R^ er en eller to substltuenter valgt uavhengig fra gruppen bestående av hydrogen, laverealkyl, laverealkcksy og halogen. Det er videre beskrevet frerrgangsnåter for fremstilling av de ovenfor angitte forbindelsene son har nyttevirkning ved behandling av hjertearytmi.Aryl-condensed and hetaryl {other-2,4-diazeplanes and dlazoclns of the general formulas: R R.. «*R ellerR eller or (XXXa) as well as aryltrethane ordinates of formulas: (Ha) (Via) ( VTb) (IVa) wherein R 1 is hydrogen, lower alkyl, benzyl, naphthyl, tlenyl, pyridinyl, phenyl, or phenyl son has one or two substituents selected from lower alkyl and lower alkoxy; R2 is hydrogen; lower alkyl; benzyl; phenyl; or halo, lower alkyl or lower alkoxy; or R 2 is -OtochCHR R 7, wherein R 7 is lower alkoxy, benzyl, dl- (lower alkyl) amino, pyrrolidino, piperidino, morpholno, phenyl, or phenyl substituted with amino, nitro or lower alkoxy; lavereallgrl; dl (lower alkyl) aminoalXyl: benzyl; phenyl; phenethyl or phenyl substituted with halogen, lower alkyl or lower alkoxy; R33 is (YaL- (CH2) m- (Xa) n-R8, where Ya, p. M, n & and R8 have different meanings; R5 is hydrogen; loweralkyl; naphthyl; thienyl; pyridinyl; benzyl; phenyl; or phenyl zone has one or two substituents selected from lower alkyl, lower alkoxy, halogen, hydroxyl, amino, dl (lower alkyl) amino, lower alkyl sulfamamido and lower acylamino; R 8 is hydrogen; lower alkyl: naphthyl; thienyl; pyridylnyl; benzyl or phenyl; two substituents selected from lower alkyl, lower alkoxy and halogen; R 50 is lower alkyl: phenyl; naphthyl; thienyl; pyridinyl: benzyl: or phenyl son has one or two substituents selected from lower alkyl, lower alkoxy and halogen; R 6 is one or two substituents selected independently of the group consisting of hydrogen, lower alkyl, lower alkoxy, halogen; nitro and lower alkyl sulfonamido or R ° is a fused benzene ring; R 2 is one or two substituents independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy and halogen. Benefits for preparing the above compounds are useful in treating cardiac arrhythmias.

NO952465A 1990-09-10 1995-06-20 Process for Preparation of Aryl-Condensed and Heteraryl-Condensed-2,4-Diazepine and 2,4-Diazocin Compounds NO952465L (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO952465A NO952465L (en) 1990-09-10 1995-06-20 Process for Preparation of Aryl-Condensed and Heteraryl-Condensed-2,4-Diazepine and 2,4-Diazocin Compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58006590A 1990-09-10 1990-09-10
US74385391A 1991-06-13 1991-06-13
NO913566A NO300268B1 (en) 1990-09-10 1991-09-10 Analogous Process for Preparation of Therapeutically Active Aryl Condensed and Hetaryl Condensed 2,4-Diazepine Compounds
NO952465A NO952465L (en) 1990-09-10 1995-06-20 Process for Preparation of Aryl-Condensed and Heteraryl-Condensed-2,4-Diazepine and 2,4-Diazocin Compounds

Publications (2)

Publication Number Publication Date
NO952465D0 NO952465D0 (en) 1995-06-20
NO952465L true NO952465L (en) 1995-06-20

Family

ID=27484208

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952465A NO952465L (en) 1990-09-10 1995-06-20 Process for Preparation of Aryl-Condensed and Heteraryl-Condensed-2,4-Diazepine and 2,4-Diazocin Compounds

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Country Link
NO (1) NO952465L (en)

Also Published As

Publication number Publication date
NO952465D0 (en) 1995-06-20

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