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Priority claimed from PCT/US1992/009932external-prioritypatent/WO1994012184A1/en
Application filed by Syntex IncfiledCriticalSyntex Inc
Publication of NO951966D0publicationCriticalpatent/NO951966D0/no
Publication of NO951966LpublicationCriticalpatent/NO951966L/no
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/33—Heterocyclic compounds
A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
A61K31/365—Lactones
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/33—Heterocyclic compounds
A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
Abstract
Stenosis, spesielt restenosis forbundet med angioplasti- eller hjerteforbiled- ningsoperasjoner, behandles ved admini- strering av en terapeutisk effektiv mengde mykofenolsyre, mykofenolat-mofe- til eller et i farmasøytisk henseende akseptabelt salt eller derivat derav.Stenosis, especially restenosis associated with angioplasty or heart bypass surgery, is treated by administering a therapeutically effective amount of mycophenolic acid, mycophenolate mofene or a pharmaceutically acceptable salt or derivative thereof.
ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 5-SUBSTITUTED-1,2-DIHYDRO-3H-PYRROLO- (1,2-A) -PYRROL-1-CARBOXYL ACIDS FROM THEIR SIMILAR NITRILS.