NO950634L - New glucan preparation - Google Patents
New glucan preparationInfo
- Publication number
- NO950634L NO950634L NO950634A NO950634A NO950634L NO 950634 L NO950634 L NO 950634L NO 950634 A NO950634 A NO 950634A NO 950634 A NO950634 A NO 950634A NO 950634 L NO950634 L NO 950634L
- Authority
- NO
- Norway
- Prior art keywords
- neutral
- production
- glucan
- glucans
- aqueous
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Den foreliggende oppfinnelse vedører nøytrale, vandige leselige /3-glukaner som har potente og spesifikke immunolo- giske effekter uten å stimulere produksjonen av visse cyto- kiner, preparater som inneholder de nye /3-glukaner, og en ny fremstillingsfremgangsmåte for disse. Det noytrale, vandige løselige /3-glukanpreparat har høy affinitet for 0-glukan- reseptoren på humane monocytter, og beholder to primære biolo- giske (eller immunologiske) aktiviteter, (1) økningen av mikrobicid aktivitet hos fagocyttceller, og (2) monocytt, neutrofil og blodplatehemopoietisk aktivitet. Ulikt løselige glukaner beskrevet i tidligere teknologi, vil det nøytrale, vandige løselige /3-glukan ifølge denne oppfinnelse verken indusere eller prime IL-1/3 og TNFa-produksjon in vitro og in vivo. Sikre og virksomme preparater av nøytralt, vandig løselige /3-glukan ifølge den foreliggende oppfinnelse kan anvendes i terapeutiske og/eller profylaktiske behandlings- regimer av mennesker og dyr for å øke deres immunrespons, uten å stimulere produksjonen av visse biokjemiske mediatorer (f.eks. IL-1/3, TNFa) som kan forårsake skadelige side- virkninger, slik som feber og betennelse.The present invention relates to neutral, aqueous readable β-glucans that have potent and specific immunological effects without stimulating the production of certain cytokines, preparations containing the novel β-glucans, and a novel process for their production. The neutral, aqueous soluble / 3-glucan preparation has high affinity for the 0-glucan receptor on human monocytes, and retains two primary biological (or immunological) activities, (1) the increase of microbicidal activity in phagocyte cells, and (2) monocyte , neutrophil and platelet hemopoietic activity. Unlike soluble glucans described in the prior art, the neutral aqueous soluble β-glucan of this invention will neither induce nor prime IL-1/3 and TNFα production in vitro and in vivo. Safe and effective preparations of neutral, aqueous soluble β-glucan of the present invention can be used in therapeutic and / or prophylactic treatment regimens of humans and animals to enhance their immune response, without stimulating the production of certain biochemical mediators (e.g. IL-1/3, TNFα) which can cause harmful side effects, such as fever and inflammation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/934,015 US5622939A (en) | 1992-08-21 | 1992-08-21 | Glucan preparation |
PCT/US1993/007904 WO1994004163A1 (en) | 1992-08-21 | 1993-08-20 | Novel glucan preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
NO950634D0 NO950634D0 (en) | 1995-02-20 |
NO950634L true NO950634L (en) | 1995-04-20 |
Family
ID=26786977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO950634A NO950634L (en) | 1992-08-21 | 1995-02-20 | New glucan preparation |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA2142811C (en) |
NO (1) | NO950634L (en) |
-
1993
- 1993-08-20 CA CA002142811A patent/CA2142811C/en not_active Expired - Lifetime
-
1995
- 1995-02-20 NO NO950634A patent/NO950634L/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO950634D0 (en) | 1995-02-20 |
CA2142811C (en) | 2006-10-31 |
CA2142811A1 (en) | 1994-03-03 |
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