NO950634L - New glucan preparation - Google Patents

New glucan preparation

Info

Publication number
NO950634L
NO950634L NO950634A NO950634A NO950634L NO 950634 L NO950634 L NO 950634L NO 950634 A NO950634 A NO 950634A NO 950634 A NO950634 A NO 950634A NO 950634 L NO950634 L NO 950634L
Authority
NO
Norway
Prior art keywords
neutral
production
glucan
glucans
aqueous
Prior art date
Application number
NO950634A
Other languages
Norwegian (no)
Other versions
NO950634D0 (en
Inventor
Spiros Jamas
Jr D Davidson Easson
Gary R Ostroff
Original Assignee
Alpha Beta Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/934,015 external-priority patent/US5622939A/en
Application filed by Alpha Beta Technology filed Critical Alpha Beta Technology
Publication of NO950634D0 publication Critical patent/NO950634D0/en
Publication of NO950634L publication Critical patent/NO950634L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Den foreliggende oppfinnelse vedører nøytrale, vandige leselige /3-glukaner som har potente og spesifikke immunolo- giske effekter uten å stimulere produksjonen av visse cyto- kiner, preparater som inneholder de nye /3-glukaner, og en ny fremstillingsfremgangsmåte for disse. Det noytrale, vandige løselige /3-glukanpreparat har høy affinitet for 0-glukan- reseptoren på humane monocytter, og beholder to primære biolo- giske (eller immunologiske) aktiviteter, (1) økningen av mikrobicid aktivitet hos fagocyttceller, og (2) monocytt, neutrofil og blodplatehemopoietisk aktivitet. Ulikt løselige glukaner beskrevet i tidligere teknologi, vil det nøytrale, vandige løselige /3-glukan ifølge denne oppfinnelse verken indusere eller prime IL-1/3 og TNFa-produksjon in vitro og in vivo. Sikre og virksomme preparater av nøytralt, vandig løselige /3-glukan ifølge den foreliggende oppfinnelse kan anvendes i terapeutiske og/eller profylaktiske behandlings- regimer av mennesker og dyr for å øke deres immunrespons, uten å stimulere produksjonen av visse biokjemiske mediatorer (f.eks. IL-1/3, TNFa) som kan forårsake skadelige side- virkninger, slik som feber og betennelse.The present invention relates to neutral, aqueous readable β-glucans that have potent and specific immunological effects without stimulating the production of certain cytokines, preparations containing the novel β-glucans, and a novel process for their production. The neutral, aqueous soluble / 3-glucan preparation has high affinity for the 0-glucan receptor on human monocytes, and retains two primary biological (or immunological) activities, (1) the increase of microbicidal activity in phagocyte cells, and (2) monocyte , neutrophil and platelet hemopoietic activity. Unlike soluble glucans described in the prior art, the neutral aqueous soluble β-glucan of this invention will neither induce nor prime IL-1/3 and TNFα production in vitro and in vivo. Safe and effective preparations of neutral, aqueous soluble β-glucan of the present invention can be used in therapeutic and / or prophylactic treatment regimens of humans and animals to enhance their immune response, without stimulating the production of certain biochemical mediators (e.g. IL-1/3, TNFα) which can cause harmful side effects, such as fever and inflammation.

NO950634A 1992-08-21 1995-02-20 New glucan preparation NO950634L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/934,015 US5622939A (en) 1992-08-21 1992-08-21 Glucan preparation
PCT/US1993/007904 WO1994004163A1 (en) 1992-08-21 1993-08-20 Novel glucan preparation

Publications (2)

Publication Number Publication Date
NO950634D0 NO950634D0 (en) 1995-02-20
NO950634L true NO950634L (en) 1995-04-20

Family

ID=26786977

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950634A NO950634L (en) 1992-08-21 1995-02-20 New glucan preparation

Country Status (2)

Country Link
CA (1) CA2142811C (en)
NO (1) NO950634L (en)

Also Published As

Publication number Publication date
NO950634D0 (en) 1995-02-20
CA2142811A1 (en) 1994-03-03
CA2142811C (en) 2006-10-31

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