NO950072L - Drug delivery device and method of preparation thereof - Google Patents

Drug delivery device and method of preparation thereof

Info

Publication number
NO950072L
NO950072L NO950072A NO950072A NO950072L NO 950072 L NO950072 L NO 950072L NO 950072 A NO950072 A NO 950072A NO 950072 A NO950072 A NO 950072A NO 950072 L NO950072 L NO 950072L
Authority
NO
Norway
Prior art keywords
polymer
matrix
drug
dextranase
crosslinking agent
Prior art date
Application number
NO950072A
Other languages
Norwegian (no)
Other versions
NO950072D0 (en
Inventor
Helle Broendsted
Lars Hovgaard
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK92895A external-priority patent/DK89592D0/en
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO950072D0 publication Critical patent/NO950072D0/en
Publication of NO950072L publication Critical patent/NO950072L/en

Links

Abstract

Legemiddelutleveringsanordning omfattende en polymermatriks og et legemiddel inneholdt i, eller omgitt av, matriksen, hvilken polymermatriks er en tverrbundet hydrogelmatriks om- fattende en dekstranasenedbrytbar poly- mer og et tverrbindingsmiddel som til- veiebringer kovalent bundet nettverks- binding mellom polymerkjedene. Anord- ningen er egnet til utlevering av lege- middel til tykktarmen. En fremgangsmåte for fremstilling av anordningen om- fatter at: a) en dekstranasenedbrytbar polymer oppløses i et oppløsnings- middel; b) et tverrbindingsmiddel som er i stand til å tverrbinde polymeren med kovalente bindinger tilsettes til oppløsningen; c) tverrbindingsmidlet tillates å reagere med den dekstranase- nedbrytbare polymer for å tilveiebringe en tverrbundet hydrogelmatriks, og legemidlet inkorporeres i oppløsningen før eller etter at reaksjonen mellom polymeren og tverrbindingsmidlet er avsluttet.Drug delivery device comprising a polymer matrix and a drug contained in, or surrounded by, the matrix, which polymer matrix is a cross-linked hydrogel matrix comprising a dextranase-degradable polymer and a cross-linking agent which provides covalently bonded network bonding between the polymer chains. The device is suitable for delivery of drug to the large intestine. A process for preparing the device comprises: a) a dextranase-degradable polymer is dissolved in a solvent; b) adding a crosslinking agent capable of crosslinking the polymer with covalent bonds to the solution; c) the crosslinking agent is allowed to react with the dextranase degradable polymer to provide a crosslinked hydrogel matrix, and the drug is incorporated into the solution before or after the reaction between the polymer and the crosslinking agent is completed.

NO950072A 1992-07-07 1995-01-06 Drug delivery device and method of preparation thereof NO950072L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK92895A DK89592D0 (en) 1992-07-07 1992-07-07 PHARMACEUTICAL DELIVERY ESTABLISHMENT AND PROCEDURES FOR PREPARING THEREOF
PCT/DK1993/000227 WO1994001136A1 (en) 1992-07-07 1993-07-06 A drug delivery device and a method of making such device

Publications (2)

Publication Number Publication Date
NO950072D0 NO950072D0 (en) 1995-01-06
NO950072L true NO950072L (en) 1995-03-01

Family

ID=26064864

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950072A NO950072L (en) 1992-07-07 1995-01-06 Drug delivery device and method of preparation thereof

Country Status (1)

Country Link
NO (1) NO950072L (en)

Also Published As

Publication number Publication date
NO950072D0 (en) 1995-01-06

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