NO950072L - Drug delivery device and method of preparation thereof - Google Patents
Drug delivery device and method of preparation thereofInfo
- Publication number
- NO950072L NO950072L NO950072A NO950072A NO950072L NO 950072 L NO950072 L NO 950072L NO 950072 A NO950072 A NO 950072A NO 950072 A NO950072 A NO 950072A NO 950072 L NO950072 L NO 950072L
- Authority
- NO
- Norway
- Prior art keywords
- polymer
- matrix
- drug
- dextranase
- crosslinking agent
- Prior art date
Links
Abstract
Legemiddelutleveringsanordning omfattende en polymermatriks og et legemiddel inneholdt i, eller omgitt av, matriksen, hvilken polymermatriks er en tverrbundet hydrogelmatriks om- fattende en dekstranasenedbrytbar poly- mer og et tverrbindingsmiddel som til- veiebringer kovalent bundet nettverks- binding mellom polymerkjedene. Anord- ningen er egnet til utlevering av lege- middel til tykktarmen. En fremgangsmåte for fremstilling av anordningen om- fatter at: a) en dekstranasenedbrytbar polymer oppløses i et oppløsnings- middel; b) et tverrbindingsmiddel som er i stand til å tverrbinde polymeren med kovalente bindinger tilsettes til oppløsningen; c) tverrbindingsmidlet tillates å reagere med den dekstranase- nedbrytbare polymer for å tilveiebringe en tverrbundet hydrogelmatriks, og legemidlet inkorporeres i oppløsningen før eller etter at reaksjonen mellom polymeren og tverrbindingsmidlet er avsluttet.Drug delivery device comprising a polymer matrix and a drug contained in, or surrounded by, the matrix, which polymer matrix is a cross-linked hydrogel matrix comprising a dextranase-degradable polymer and a cross-linking agent which provides covalently bonded network bonding between the polymer chains. The device is suitable for delivery of drug to the large intestine. A process for preparing the device comprises: a) a dextranase-degradable polymer is dissolved in a solvent; b) adding a crosslinking agent capable of crosslinking the polymer with covalent bonds to the solution; c) the crosslinking agent is allowed to react with the dextranase degradable polymer to provide a crosslinked hydrogel matrix, and the drug is incorporated into the solution before or after the reaction between the polymer and the crosslinking agent is completed.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK92895A DK89592D0 (en) | 1992-07-07 | 1992-07-07 | PHARMACEUTICAL DELIVERY ESTABLISHMENT AND PROCEDURES FOR PREPARING THEREOF |
PCT/DK1993/000227 WO1994001136A1 (en) | 1992-07-07 | 1993-07-06 | A drug delivery device and a method of making such device |
Publications (2)
Publication Number | Publication Date |
---|---|
NO950072D0 NO950072D0 (en) | 1995-01-06 |
NO950072L true NO950072L (en) | 1995-03-01 |
Family
ID=26064864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO950072A NO950072L (en) | 1992-07-07 | 1995-01-06 | Drug delivery device and method of preparation thereof |
Country Status (1)
Country | Link |
---|---|
NO (1) | NO950072L (en) |
-
1995
- 1995-01-06 NO NO950072A patent/NO950072L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO950072D0 (en) | 1995-01-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |