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Priority claimed from US08/026,800external-prioritypatent/US5505931A/en
Priority claimed from PCT/US1993/006254external-prioritypatent/WO1994000145A1/en
Application filed by Dow Chemical Co, Inst Molecular Biology IncfiledCriticalDow Chemical Co
Publication of NO945093D0publicationCriticalpatent/NO945093D0/en
Publication of NO945093LpublicationCriticalpatent/NO945093L/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Det beskrives systemer for målrettet avgivelse av spesifikke blandinger, hvor vekstfaktorer er koblet, eventuelt ved bruk av et syrespaltbart sammenkoblende ledd, til en polyaminometylenfosfonsyreligand, og som er særlig egnet for målrettet avgivelse til ben. Når det syrespaltbare sammen- koblende ledd er tilstede, aktiveres blandingen for vekst- faktorene på det aktuelle bensetet, mens det forblir inaktivt i kroppens kretsløp. En fremgangsmåte for fremstilling av forbindelsen og blandingen er også beskrevet.There are disclosed systems for targeted delivery of specific compositions, wherein growth factors are coupled, optionally by the use of an acid-cleavable linking link, to a polyaminomethylene phosphonic acid ligand, and which is particularly suitable for targeted delivery to bone. When the acid-cleavable linking link is present, the mixture is activated for the growth factors of the particular bone, while remaining inactive in the body's circulation. A process for the preparation of the compound and mixture is also described.
NO945093A1992-06-301994-12-30
Targeted release of growth factors for bone regeneration
NO945093L
(en)
(54) Heteroaryl Succinamides, Pharmaceutical Compositions Containing the Same and Methods for Treatment of the Diseases Caused by Metalloproteinase Activity
3 ', 5'-Ditertbutyl-4'-hydroxyflavone, process for their preparation and pharmaceutical composition with antioxidant and antivasoconstriction activity