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Priority claimed from PCT/US1993/006120external-prioritypatent/WO1994000555A2/en
Application filed by Cetus Oncology CorpfiledCriticalCetus Oncology Corp
Publication of NO945021D0publicationCriticalpatent/NO945021D0/en
Publication of NO945021LpublicationCriticalpatent/NO945021L/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Peptides Or Proteins
(AREA)
Abstract
Forbindelser med proteolytisk inhibitorisk aktivitet som er nyttige for behandling av sykdommer, spesielt for behandling av sepsis, AIDS eller autoimmune sykdommer som er et resultat av en reduksjon i det sirkulerende nivået av modne proteinhormoner avledet fra den proteolytisk spaltningen av prohormonforløpere så som 26 kD TNF, og fremgangsmåter for identifisering av forbindelser som har ønsket inhibitorisk aktivitet er tilveiebragt.Compounds with proteolytic inhibitory activity useful for the treatment of diseases, in particular for the treatment of sepsis, AIDS or autoimmune diseases which result from a reduction in the circulating level of mature protein hormones derived from the proteolytic cleavage of prohormone precursors such as 26 kD TNF, and methods for identifying compounds that have desired inhibitory activity are provided.
NO945021A1992-06-251994-12-23
Compositions for Inhibition of Protein Hormone Formation and Use thereof
NO945021L
(en)