NO944429L - Enantiomeric dynemicin analogs, method of preparation and use thereof - Google Patents

Enantiomeric dynemicin analogs, method of preparation and use thereof

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Publication number
NO944429L
NO944429L NO944429A NO944429A NO944429L NO 944429 L NO944429 L NO 944429L NO 944429 A NO944429 A NO 944429A NO 944429 A NO944429 A NO 944429A NO 944429 L NO944429 L NO 944429L
Authority
NO
Norway
Prior art keywords
enantiomeric
compound
ring system
preparation
fused rings
Prior art date
Application number
NO944429A
Other languages
Norwegian (no)
Other versions
NO944429D0 (en
Inventor
Adrian L Smith
Chan-Kou Hwang
Sebastian V Wendeborn
Kyriacos C Nicolaou
Erwin P Schreiner
Wilhelm Stahl
Wei-Min Dai
Peter E Maligres
Toshio Susuki
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/886,984 external-priority patent/US5276159A/en
Priority claimed from US07/939,104 external-priority patent/US5281710A/en
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of NO944429D0 publication Critical patent/NO944429D0/en
Publication of NO944429L publication Critical patent/NO944429L/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

En enantiomer av en fusjonert ringsystemforbindelse inneholdende en epoksidgruppe på en side av de fusjon- erte ringer og en endiyn-makrosyklisk ring på den andre side av de fusjonerte ringer. De enantiomere forbindelser har forhøyede DNA-spaltende, antimikro- bielle og tumorvekstinhiberende egen- skaper i forhold til deres racemater. Kimære forbindelser hvor den enantio- mere, fusjonerte ringsystemforbindelse foreligger som et aglykon bundet til (i) en sukkergruppe som oligosakkarid- del eller (ii) et monoklonalt antistoff eller en antistoffbindingssetedel derav som immunreagerer med tumormålceller, er også beskrevet. Preparater innehol- dende en enantiomer forbindelse eller en enantiomer kimær og fremgangsmåter for fremstilling av en enantiomer for- bindelse, er også beskrevet.An enantiomer of a fused ring system compound containing an epoxide group on one side of the fused rings and an endyynocyclic ring on the other side of the fused rings. The enantiomeric compounds have elevated DNA cleavage, antimicrobial and tumor growth inhibitory properties in relation to their racemates. Chimeric compounds in which the enantiomerized ring system compound is present as an aglycone bound to (i) a sugar moiety as an oligosaccharide moiety or (ii) a monoclonal antibody or antibody binding site thereof that immunoreact with tumor target cells are also described. Compositions containing an enantiomeric compound or an enantiomeric chimera and methods for preparing an enantiomeric compound are also described.

NO944429A 1992-05-21 1994-11-18 Enantiomeric dynemicin analogs, method of preparation and use thereof NO944429L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/886,984 US5276159A (en) 1990-08-01 1992-05-21 Dynemicin analogs: syntheses, methods of preparation and use
US07/939,104 US5281710A (en) 1990-08-01 1992-09-01 Dynemicin analogs: synthesis, methods of preparation and use
PCT/US1993/004708 WO1993023046A1 (en) 1992-05-21 1993-05-18 Enantiomeric cynemicin analogs, preparation and use thereof

Publications (2)

Publication Number Publication Date
NO944429D0 NO944429D0 (en) 1994-11-18
NO944429L true NO944429L (en) 1995-01-23

Family

ID=27377381

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944429A NO944429L (en) 1992-05-21 1994-11-18 Enantiomeric dynemicin analogs, method of preparation and use thereof

Country Status (1)

Country Link
NO (1) NO944429L (en)

Also Published As

Publication number Publication date
NO944429D0 (en) 1994-11-18

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