NO944197L - Moenomycin cleavage products with hydroxylated and oxidized lipid side chain - Google Patents

Moenomycin cleavage products with hydroxylated and oxidized lipid side chain

Info

Publication number
NO944197L
NO944197L NO944197A NO944197A NO944197L NO 944197 L NO944197 L NO 944197L NO 944197 A NO944197 A NO 944197A NO 944197 A NO944197 A NO 944197A NO 944197 L NO944197 L NO 944197L
Authority
NO
Norway
Prior art keywords
hydrogen
hydroxylated
substituent
atom
moenomycin
Prior art date
Application number
NO944197A
Other languages
Norwegian (no)
Other versions
NO944197D0 (en
Inventor
Werner Aretz
Udo Hedtmann
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19934337630 external-priority patent/DE4337630A1/en
Priority claimed from DE19944402167 external-priority patent/DE4402167A1/en
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO944197D0 publication Critical patent/NO944197D0/en
Publication of NO944197L publication Critical patent/NO944197L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60—Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

MÅ med hydroksylert eller oksydert lipldsidekjeder og Moenomycln-analoger, fremgangsmåte for fremstilling og anvendelse av disse forbindelsene er beskrevet. MÅ har formel I C-atomet som bærer sub- R1, R2, R4 og R5 uavhengig av hverandre er en hydrok- sylgruppe eller hydrogen og R3 betyr hydrogen, i det bindingen mellom bærer substltuenten R4 og C-atomet som stltuenten R5 er en enkelt binding, eller R1 og R2 er uavhengig av hverandre en hydroksylgruppe eller hydrogen og R3 betyr hydrogen, i det bindingen mellom bærer substituenten R4 og C-atomet som stltuenten R5 er en dobbelt binding, eller R1, R2 og R5 uavhengig av hverandre er en gruppe eller hydrogen og R3 og R4 er sammen en oksogruppe. MÅ blir av mikroorganismen til slekten Cryptococcus hydroksylert og oksydert i lipldkjeden og er i denne formen en utgangsforbindelse for fremstilling av Moenomycin-analoger som kan anvendes som legemiddel. Moenomycin-analogene har følgende kjemiske struktur C-atomet som bærer sub- hydroksyl- 11 NHAc hvor R1 til R5 har ovennevnte betydning.MUST with hydroxylated or oxidized lipid side chains and Moenomycline analogs, process for preparation and use of these compounds are described. MUST have the formula I C atom bearing the sub-R 1, R 2, R 4 and R 5 independently of one another is a hydrocyl group or hydrogen and R 3 means hydrogen, in that the bond between the substituent R 4 and the C atom of which the substituent R 5 is a single bond, or R1 and R2 are independently a hydroxyl group or hydrogen and R3 is hydrogen, in that the bond between the substituent R4 and the C atom of which the substituent R5 is a double bond or R1, R2 and R5 are independently a group or hydrogen and R 3 and R 4 are together an oxo group. MUST be hydroxylated and oxidized by the microorganism of the genus Cryptococcus in the lipid chain and in this form is a starting compound for the preparation of Moenomycin analogues which can be used as a drug. The monoenomycin analogs have the following chemical structure, the C atom, which carries the sub-hydroxyl-11 NHAc wherein R 1 to R 5 have the above meaning.

NO944197A 1993-11-04 1994-11-03 Moenomycin cleavage products with hydroxylated and oxidized lipid side chain NO944197L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19934337630 DE4337630A1 (en) 1993-11-04 1993-11-04 MA having a hydroxylated or oxidised lipid side chain and moenomycin analogues, and a process for the preparation and the use of these compounds
DE19944402167 DE4402167A1 (en) 1994-01-26 1994-01-26 New moenomycin derivs. with hydroxylated or oxidised lipid side chain

Publications (2)

Publication Number Publication Date
NO944197D0 NO944197D0 (en) 1994-11-03
NO944197L true NO944197L (en) 1995-05-05

Family

ID=25930968

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944197A NO944197L (en) 1993-11-04 1994-11-03 Moenomycin cleavage products with hydroxylated and oxidized lipid side chain

Country Status (7)

Country Link
EP (1) EP0652205A3 (en)
JP (1) JPH07188098A (en)
KR (1) KR950014314A (en)
AU (1) AU7759894A (en)
CA (1) CA2135041A1 (en)
FI (1) FI945165A (en)
NO (1) NO944197L (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19709897A1 (en) * 1997-03-11 1998-09-17 Hoechst Ag Bismuth salts of antibiotics of the moenomycin group, process for their preparation, their use and medicaments containing such salts
EP1069130B1 (en) * 1999-07-15 2004-08-11 Hoechst Marion Roussel Moenomycin A Derivatives, their preparation, and use as antibacterial products
US9115358B2 (en) 2006-08-11 2015-08-25 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
EP2205074A4 (en) 2007-10-04 2013-07-31 Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
WO2013152277A2 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
US10106833B2 (en) 2012-04-06 2018-10-23 President And Fellows Of Harvard College Methods and compounds for identifying glycosyltransferase inhibitors
WO2013152279A1 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Chemoenzymatic methods for synthesizing moenomycin analogs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2085855T3 (en) * 1988-08-20 1996-06-16 Hoechst Ag NEW MICROORGANISM FOR THE DEGRADATION OF MOENOMYCINES, PROCEDURE FOR DEGRADATION, AS WELL AS THE USE OF DEGRADATION PRODUCTS.
ATE155171T1 (en) * 1991-03-08 1997-07-15 Hoechst Ag METHOD FOR PRODUCING MA

Also Published As

Publication number Publication date
AU7759894A (en) 1995-05-18
FI945165A0 (en) 1994-11-02
JPH07188098A (en) 1995-07-25
FI945165A (en) 1995-05-05
EP0652205A2 (en) 1995-05-10
KR950014314A (en) 1995-06-15
CA2135041A1 (en) 1995-05-05
NO944197D0 (en) 1994-11-03
EP0652205A3 (en) 1995-08-30

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