NO943988D0 - 7-Disubstituted-methyl-4-oxo-3H, 5H-pyrrolo- (3,2-d) pyrimidine and pharmaceutical uses and preparations containing the same - Google Patents

7-Disubstituted-methyl-4-oxo-3H, 5H-pyrrolo- (3,2-d) pyrimidine and pharmaceutical uses and preparations containing the same

Info

Publication number
NO943988D0
NO943988D0 NO943988A NO943988A NO943988D0 NO 943988 D0 NO943988 D0 NO 943988D0 NO 943988 A NO943988 A NO 943988A NO 943988 A NO943988 A NO 943988A NO 943988 D0 NO943988 D0 NO 943988D0
Authority
NO
Norway
Prior art keywords
pyrrolo
disubstituted
pyrimidine
oxo
methyl
Prior art date
Application number
NO943988A
Other languages
Norwegian (no)
Other versions
NO943988L (en
NO303637B1 (en
Inventor
Shir Niwas
Iii John A Secrist
John A Montgomery
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Publication of NO943988D0 publication Critical patent/NO943988D0/en
Publication of NO943988L publication Critical patent/NO943988L/en
Publication of NO303637B1 publication Critical patent/NO303637B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/40—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO943988A 1992-04-21 1994-10-20 7-Disubstituted-methyl-4-oxo-3H, 5H-pyrrolo-3,2-dipyrimidine, pharmaceutical composition, and use thereof NO303637B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87144192A 1992-04-21 1992-04-21
PCT/US1993/002841 WO1993021187A1 (en) 1992-04-21 1993-03-25 7-DISUBSTITUTED-METHYL-4-OXO-3H^_,5H^_-PYRROLO[3,2-d^_]PYRIMIDINE AND PHARMACEUTICAL USES AND COMPOSITIONS CONTAINING THE SAME

Publications (3)

Publication Number Publication Date
NO943988D0 true NO943988D0 (en) 1994-10-20
NO943988L NO943988L (en) 1994-10-20
NO303637B1 NO303637B1 (en) 1998-08-10

Family

ID=25357439

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943988A NO303637B1 (en) 1992-04-21 1994-10-20 7-Disubstituted-methyl-4-oxo-3H, 5H-pyrrolo-3,2-dipyrimidine, pharmaceutical composition, and use thereof

Country Status (10)

Country Link
EP (1) EP0638080A4 (en)
JP (1) JPH07507062A (en)
KR (1) KR950701335A (en)
AU (1) AU4276693A (en)
CA (1) CA2133346A1 (en)
FI (1) FI944933A (en)
HU (1) HUT71559A (en)
NO (1) NO303637B1 (en)
RU (1) RU94046387A (en)
WO (1) WO1993021187A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9809178A (en) * 1997-05-29 2000-08-01 Novartis Ag 2-amino-7- (1-substituted-2-hydroxyethyl) -3,5-dihydro-pyrrolo [3,2-d] pyrimidin-4-ones
US6355244B1 (en) 1997-11-17 2002-03-12 University Of Kentucky Research Foundation Methods and compositions for the treatment of psoriasis
US6174888B1 (en) 1998-05-28 2001-01-16 Novartis Ag 2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin-4-ones
GB0215392D0 (en) * 2002-07-03 2002-08-14 Glaxo Group Ltd Chemical compounds
US7557113B2 (en) 2003-08-26 2009-07-07 Teijin Pharma Limited Substituted pyrrolo[3,2-d]pyrimidine derivatives
JPWO2005019218A1 (en) * 2003-08-26 2006-10-19 帝人ファーマ株式会社 Pyrrolopyrimidinethione derivatives
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
US7763257B2 (en) 2004-12-09 2010-07-27 Christina Juneau Compositions comprising transforming growth factor (TGF)-β1 and TGF-β2 in admixture of proteins obtained from dairy products
US8138191B2 (en) 2007-01-11 2012-03-20 Critical Outcome Technologies Inc. Inhibitor compounds and cancer treatment methods
EP2225226B1 (en) 2007-12-26 2016-08-17 Critical Outcome Technologies, Inc. Compounds and their use in a method for treatment of cancer
EP2552915B1 (en) 2010-04-01 2017-07-19 Critical Outcome Technologies Inc. Compounds for the treatment of hiv

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2866478B2 (en) * 1989-10-31 1999-03-08 バイオクリスト・ファーマシューティカルズ・インコーポレイテッド Purine nucleoside phosphorylase inhibitors
US5189039A (en) * 1989-11-29 1993-02-23 Biocryst, Inc. 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo[3,2d]pyrimidine and pharmaceutical uses and compositions containing the same

Also Published As

Publication number Publication date
EP0638080A1 (en) 1995-02-15
RU94046387A (en) 1996-09-27
WO1993021187A1 (en) 1993-10-28
JPH07507062A (en) 1995-08-03
KR950701335A (en) 1995-03-23
EP0638080A4 (en) 1995-08-23
FI944933A0 (en) 1994-10-20
FI944933A (en) 1994-10-20
HUT71559A (en) 1995-12-28
AU4276693A (en) 1993-11-18
HU9403021D0 (en) 1994-12-28
NO943988L (en) 1994-10-20
NO303637B1 (en) 1998-08-10
CA2133346A1 (en) 1993-10-28

Similar Documents

Publication Publication Date Title
NO305952B1 (en) 1,5-benzodiazepine derivatives, their use and pharmaceutical preparations
IL89974A0 (en) Aryl and heteroaryl bicyclodiones,their preparations and their use as herbicides
AU8405991A (en) Pyrimidine derivative and medicine
AU7809891A (en) 2,4-diamino-6-(2-chlorophenyl)pyrimidines and use in medicine
PH27460A (en) Pyrimidine derivatives and herbicidal composition containing the same
ZA941993B (en) Amidine derivatives containing heterocyclic groups the preparation and use thereof
DE3677445D1 (en) 2-SUBSTITUTED-E-CONDENSED (1,5-C) -PYRIMIDINE, PHARMACEUTICAL PREPARATIONS AND THEIR USE.
DE59407063D1 (en) DEODORATING PREPARATIONS
DK0385279T3 (en) Biologically active agents and preparations and materials containing the biologically active agents
BR9207062A (en) Tablet formulation
NO943988L (en) 7-Disubstituted-methyl-4-oxo-3H, 5H-pyrrolo- (3,2-d) pyrimidine and pharmaceutical uses and preparations containing the same
DE69429514D1 (en) ANTIPARASITARY PREPARATIONS
AU9044091A (en) Pharmaceuticals
AU5067193A (en) Pyranoquinolines and their use as pharmaceuticals
NO931008D0 (en) PHARMACEUTICAL RELATIONS
BR9605046B1 (en) n- (pyrimidinyl) -benzenesulfonamide compounds and pharmaceutical preparation containing them.
AU8099691A (en) Pyrimidinyl and triazinyl herbicides
DK334989D0 (en) ANTIVIRAL RELATIONS AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH PRODUCTS.
NO951350D0 (en) Pharmaceutical preparations containing 3-substituted 2-oxindole-1-carboxamides
NO303392B1 (en) Polyethers, and their preparation and use
ITMI932019A0 (en) ANTIVIRAL PHARMACEUTICAL COMPOSITION CONTAINING 2-AMINO 4,6-DICHLOROPYRIMIDINE AND METHISOPRINOL
NO179907C (en) Benzoquinoxalines and pharmaceutical preparations containing the same
AU7654181A (en) 5-hydroxy-5h-(1)benzopyranon(4,3-d) pyrimidines and pharmaceutical preparations
KR950000305U (en) Hammock
DE59403371D1 (en) Polyisocyanate preparations