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Priority claimed from PCT/JP1993/000264external-prioritypatent/WO1993017702A1/en
Application filed by Daiichi Seiyaku CofiledCriticalDaiichi Seiyaku Co
Publication of NO943251D0publicationCriticalpatent/NO943251D0/en
Publication of NO943251LpublicationCriticalpatent/NO943251L/en
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents
(AREA)
Abstract
En oral vaksine omfattende et kompleks av antigener og et lipid, hvor lipidet omfatter et glykolipid med man-nose og/eller et fosfolipid som er et fosfatidylserin. Den orale vaksine er i stand til effektivt å produsere anti-stoffer mot antigenene inneholdt deri etter at den er oralt administrert til levende legemer. Det er derfor mulig-gjort å produsere en oral vaksine inneholdende mikrobielle antigener eller svekkede mikroorganismer hvilke, ifølge kjent teknikk, ikke kunne absor-beres ved oral administrering og som ikke kunne produsere antistoffene mot antigenene.An oral vaccine comprising a complex of antigens and a lipid, wherein the lipid comprises a glycolipid with mannose and / or a phospholipid which is a phosphatidylserine. The oral vaccine is capable of efficiently producing antibodies to the antigens contained therein after being orally administered to living bodies. It is therefore possible to produce an oral vaccine containing microbial antigens or attenuated microorganisms which, according to the prior art, could not be absorbed by oral administration and which could not produce the antibodies to the antigens.