NO942840L - Antithrombotic polypeptides as antagonists for binding of VWF to platelets or to subendothelium - Google Patents

Antithrombotic polypeptides as antagonists for binding of VWF to platelets or to subendothelium

Info

Publication number
NO942840L
NO942840L NO942840A NO942840A NO942840L NO 942840 L NO942840 L NO 942840L NO 942840 A NO942840 A NO 942840A NO 942840 A NO942840 A NO 942840A NO 942840 L NO942840 L NO 942840L
Authority
NO
Norway
Prior art keywords
vwf
subendothelium
polypeptides
binding
platelets
Prior art date
Application number
NO942840A
Other languages
Norwegian (no)
Other versions
NO942840D0 (en
Inventor
Reinhard Fleer
Alain Fournier
Jean-Dominique Guitton
Gerard Jung
Patrice Yeh
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO942840D0 publication Critical patent/NO942840D0/en
Publication of NO942840L publication Critical patent/NO942840L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Rekomblnante polypeptider bestående av en adheslvdel avledet fra strukturen til vWF, i stand til i det minste partlelt å antagonisere binding av vWF til plater og/eller subendotel, og en del som tillater polypeptldets stabilisering og presentasjon In vlvo. Polypeptidenes fremstilling samt farmasøytiske preparater inneholdende polypeptidene beskrives.Recombinant polypeptides consisting of an adhesive moiety derived from the structure of the vWF, capable of at least partially antagonizing binding of the vWF to plates and / or subendothelium, and a moiety allowing the stabilization and presentation of the polypeptide In vlvo. The preparation of the polypeptides as well as pharmaceutical preparations containing the polypeptides are described.

NO942840A 1992-01-31 1994-07-29 Antithrombotic polypeptides as antagonists for binding of VWF to platelets or to subendothelium NO942840L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9201066A FR2686901A1 (en) 1992-01-31 1992-01-31 NOVEL ANTITHROMBOTIC POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
PCT/FR1993/000087 WO1993015200A1 (en) 1992-01-31 1993-01-28 Antithrombotic polypeptides as antagonists of the binding of vwf to platelets or to subendothelium

Publications (2)

Publication Number Publication Date
NO942840D0 NO942840D0 (en) 1994-07-29
NO942840L true NO942840L (en) 1994-09-29

Family

ID=9426193

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942840A NO942840L (en) 1992-01-31 1994-07-29 Antithrombotic polypeptides as antagonists for binding of VWF to platelets or to subendothelium

Country Status (7)

Country Link
EP (1) EP0625199A1 (en)
JP (1) JPH07503369A (en)
CA (1) CA2126092A1 (en)
FI (1) FI943565A0 (en)
FR (1) FR2686901A1 (en)
NO (1) NO942840L (en)
WO (1) WO1993015200A1 (en)

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Also Published As

Publication number Publication date
CA2126092A1 (en) 1993-08-05
JPH07503369A (en) 1995-04-13
FI943565A (en) 1994-07-29
FR2686901A1 (en) 1993-08-06
FI943565A0 (en) 1994-07-29
EP0625199A1 (en) 1994-11-23
WO1993015200A1 (en) 1993-08-05
NO942840D0 (en) 1994-07-29

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