NO941314L - Device for transdermal administration of melatonin - Google Patents

Device for transdermal administration of melatonin

Info

Publication number
NO941314L
NO941314L NO941314A NO941314A NO941314L NO 941314 L NO941314 L NO 941314L NO 941314 A NO941314 A NO 941314A NO 941314 A NO941314 A NO 941314A NO 941314 L NO941314 L NO 941314L
Authority
NO
Norway
Prior art keywords
melatonin
skin
transdermal
transdermal administration
relates
Prior art date
Application number
NO941314A
Other languages
Norwegian (no)
Other versions
NO941314D0 (en
Inventor
F Eugene Yates
Lina T Taskovich
Su Il Yum
Nieves Marzan Crisologo
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1992/008919 external-priority patent/WO1993007870A1/en
Application filed by Alza Corp filed Critical Alza Corp
Publication of NO941314L publication Critical patent/NO941314L/en
Publication of NO941314D0 publication Critical patent/NO941314D0/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Den foreliggende oppfinnelse vedrører transdermal administrering av melatonin sammen med et egnet permea- sjonsfremmende middel. Oppfinnelsen innbefatter en anord- ning (10) for transdermal medikamentavgivelse, omfattende en matriks som er innrettet til å plasseres i melatonin- og permeasjonsmiddel-overførende relasjon med hudområdet (18). Matriksen (12) omfatter tilstrekkelige mengder av et permeasjonsfremmende middel og av melatonin, i kombina- sjon, til kontinuerlig å administrere melatoninet til huden (18) over et forutbestemt tidsrom til at det oppnås virkningsfulle terapeutiske resultater. Oppfinnelsen ved- rører også en fremgangsmåte for transdermal administrering av en terapeutisk virkningsfull mengde av melatonin sammen med en hudpermeasjonsfremmende mengde av et egnet permea- sjonsfremmende middel. Oppfinnelsen innbefatter også frem- gangsmåter for transdermal avgivelse av melatonin etter gitte tids- og hastighetsmønstre for å simulere den natur- lige circadiane rytmiske profil til melaton hos pattedyr.The present invention relates to transdermal administration of melatonin together with a suitable permeation enhancer. The invention includes a device (10) for transdermal drug delivery, comprising a matrix adapted to be placed in melatonin and permeability transmitting relationship with the skin region (18). The matrix (12) comprises sufficient amounts of a permeation promoting agent and of melatonin, in combination, to continuously administer the melatonin to the skin (18) for a predetermined period of time to achieve effective therapeutic results. The invention also relates to a method for transdermally administering a therapeutically effective amount of melatonin together with a skin permeation promoting amount of a suitable permeation enhancer. The invention also includes methods for transdermal delivery of melatonin according to given time and velocity patterns to simulate the natural circadian rhythmic profile of melatonin in mammals.

NO941314A 1991-10-18 1994-04-13 Device for transdermal administration of melatonin NO941314D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77921591A 1991-10-18 1991-10-18
PCT/US1992/008919 WO1993007870A1 (en) 1991-10-18 1992-10-16 Device for the transdermal administration of melatonin

Publications (2)

Publication Number Publication Date
NO941314L true NO941314L (en) 1994-04-13
NO941314D0 NO941314D0 (en) 1994-04-13

Family

ID=26785103

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941314A NO941314D0 (en) 1991-10-18 1994-04-13 Device for transdermal administration of melatonin

Country Status (1)

Country Link
NO (1) NO941314D0 (en)

Also Published As

Publication number Publication date
NO941314D0 (en) 1994-04-13

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