Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1993/000961external-prioritypatent/WO1994002452A1/en
Application filed by Eisai Co LtdfiledCriticalEisai Co Ltd
Publication of NO940984D0publicationCriticalpatent/NO940984D0/en
Publication of NO940984LpublicationCriticalpatent/NO940984L/en
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Den foreliggende oppfinnelse tilveiebringer et nytt benzen- derivat som er nyttig som en preventiv og medisinsk behand- lende medisin for arteriosklerose, og en kolesterol-0-acyl- transferaseinhibitor omfattende benzenderivatet som en aktiv bestanddel. Bensenderivatet i samsvar med den foreliggende oppfinnelse representeres ved den følgende generelle formel (I): ,3 (I) hvori R1 representerer en karboksylgruppe som kan være beskyttet eller en gruppe representert ved formelen: - H hvori R5 representerer en lavere alkylgruppe eller en hydroksyalkylgruppe og R6 representerer et hydrogenatom eller en hydroksylgruppe, R2 representerer et hydrogenatom, en lavere alkylgruppe eller lignende, R3 og R4 representerer hver et hydrogenatom.eller en hydroksylgruppe, og p er et heltall på l til 6.The present invention provides a novel benzene derivative useful as a preventive and medical therapeutic agent for arteriosclerosis, and a cholesterol O-acyl transferase inhibitor comprising the benzene derivative as an active ingredient. The benzene derivative of the present invention is represented by the following general formula (I):, 3 (I) wherein R 1 represents a carboxyl group which may be protected or a group represented by the formula: - H wherein R 5 represents a lower alkyl group or a hydroxyalkyl group and R6 represents a hydrogen atom or a hydroxyl group, R2 represents a hydrogen atom, a lower alkyl group or the like, R3 and R4 each represent a hydrogen atom or a hydroxyl group, and p is an integer of 1 to 6.
Use of an .alpha.-tocopherol phosphate or a derivative thereof for preparing cosmetic, dermatological or pharmaceutical compositions, and compositions thereby obtained
DERIVATIVES OF THE OXIME OF OCTAHIDRONAFTALENO FOR THE INHIBITION OF THE CHOLESTEROL SYNTHESIS, PROCEDURES FOR ITS PREPARATION AND COMPOSITIONS THAT CONTAIN THEM.