NO940448L - Novel Leukotriene B4 Antagonists, Methods of Preparing Such and Their Use as Pharmaceutical Agents - Google Patents

Novel Leukotriene B4 Antagonists, Methods of Preparing Such and Their Use as Pharmaceutical Agents

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Publication number
NO940448L
NO940448L NO940448A NO940448A NO940448L NO 940448 L NO940448 L NO 940448L NO 940448 A NO940448 A NO 940448A NO 940448 A NO940448 A NO 940448A NO 940448 L NO940448 L NO 940448L
Authority
NO
Norway
Prior art keywords
antagonists
radical
pharmaceutical agents
preparing
methods
Prior art date
Application number
NO940448A
Other languages
Norwegian (no)
Other versions
NO940448D0 (en
Inventor
Werner Skuballa
Bernd Buchmann
Josef Heindi
Wolfgang Frohlich
Roland Ekerdt
Claudia Giesen
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4127193A external-priority patent/DE4127193A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO940448D0 publication Critical patent/NO940448D0/en
Publication of NO940448L publication Critical patent/NO940448L/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Leukotrien-B4-antagonister med formel I (D hvori X representerer C,-C4-alkoksy eller -S(0)p-(C1-C4)-alkyl, p representerer O, l eller 2, Y representerer et hydrogenatom eller radikalet CO-A-COR2, hvori A represen- terer en alkylengruppe med 1-6 C-atomer i kjeden, eller et radikal R! og R2 representerer radikalet OH, -O- ( Cj-C4) -alkyl, -O- ( C3-C6) -sykloalkyl, -O- ( C6-C10) -aryl, -O- ( C7-C12) -aralkyl eller radikalet NR3R4, hvor R3 og R, betegner hydrogen, (Cj-C4 )-alkyl, (C3- C6)-sykloalkyl eller ( C7-C12)-aralkyl så vel som deres salter med fysiologisk forenlige baser og deres syklodekstrin- clathrater, en fremgangsmåte for deres fremstilling og anvendelse som farma- søytiske midler er også beskrevet.Leukotriene B4 antagonists of formula I (D wherein X represents C, -C4 alkoxy or -S (O) p- (C1-C4) alkyl, p represents O, 1 or 2, Y represents a hydrogen atom or radical CO -A-COR2, wherein A represents an alkylene group having 1-6 C atoms in the chain, or a radical R 1 and R 2 represents the radical OH, -O- (C 1 -C 4) alkyl, -O- (C 3 - C6) -cycloalkyl, -O- (C6-C10) -aryl, -O- (C7-C12) -aralkyl or radical NR3R4, wherein R3 and R, represent hydrogen, (C1-C4) -alkyl, ) -cycloalkyl or (C7-C12) -aralkyl as well as their salts with physiologically compatible bases and their cyclodextrin clathrates, a process for their preparation and use as pharmaceutical agents are also described.

NO940448A 1991-08-15 1994-02-10 Novel Leukotriene B4 Antagonists, Methods of Preparing Such and Their Use as Pharmaceutical Agents NO940448L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4127193A DE4127193A1 (en) 1991-08-15 1991-08-15 NEW LEUKOTRIEN-B (ARROW DOWN) 4 (ARROW DOWN) ANTAGONISTS, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
PCT/EP1992/001816 WO1993004056A1 (en) 1991-08-15 1992-08-06 New leukotriene-b4 antagonists, methods of preparing them and their use as drugs

Publications (2)

Publication Number Publication Date
NO940448D0 NO940448D0 (en) 1994-02-10
NO940448L true NO940448L (en) 1994-02-10

Family

ID=25906438

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940448A NO940448L (en) 1991-08-15 1994-02-10 Novel Leukotriene B4 Antagonists, Methods of Preparing Such and Their Use as Pharmaceutical Agents

Country Status (1)

Country Link
NO (1) NO940448L (en)

Also Published As

Publication number Publication date
NO940448D0 (en) 1994-02-10

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