NO940321L - Compounds with angiotensin II - antagonistic activity - Google Patents

Compounds with angiotensin II - antagonistic activity

Info

Publication number
NO940321L
NO940321L NO940321A NO940321A NO940321L NO 940321 L NO940321 L NO 940321L NO 940321 A NO940321 A NO 940321A NO 940321 A NO940321 A NO 940321A NO 940321 L NO940321 L NO 940321L
Authority
NO
Norway
Prior art keywords
hydrogen
aryl
linear
alkyl
branched alkyl
Prior art date
Application number
NO940321A
Other languages
Norwegian (no)
Other versions
NO940321D0 (en
Inventor
Aldo Salimbeni
Davide Poma
Elso Manghisi
Carlo Scolastico
Original Assignee
Luso Farmaco Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI912182A external-priority patent/IT1250749B/en
Application filed by Luso Farmaco Inst filed Critical Luso Farmaco Inst
Publication of NO940321D0 publication Critical patent/NO940321D0/en
Publication of NO940321L publication Critical patent/NO940321L/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Forbindelser med formel (I). hvor. R er C,.lineært eller forgrenet alkyl,. R, er hydrogen, C,.lineært eller forgrenet alkyl,. aryl eller arylalkyl hvor aryl er fenyl, naftyl, 2-. tienyl, 2-furanyl, eventuelt substituert med ett eller flere halogener, C,.-alkyl, C,.-alkoksy,. hydroksy, karboksy eller C,.lineære eller forgre-. nede alkoksykarbonylgrupper;. når N og X er forbundet ned en dobbeltbinding er R,. selvfølgelig ikke nærværende;. Rj er hydrogen, C,.-lineær eller forgrenet alkyl,. hydroksy, amino, aryl, hvor aryl er definert som ovenfor, eller en gruppe med formel NHhvor A er Cj-C^acyl, CN, NO, CONHB eller CSNHB hvor B er. hydrogen, C,-Ct-lineær eller forgrenet alkyl, C.-. cykloalkyl, aryl som definert ovenfor;. Rj er hydrogen eller ett eller flere halogenatomer;. X er CO eller en C-R-gruppe hvor Rkan være 0R. (hvor R, må være tilstede og har de ovennevnte betydninger), aryl eventuelt substituert med karboksy- eller hydroksygrupper eller CHOR, hvor Rj er hydrogen, lavere alkyl, arylalkyl hvori aryld-. elen er som definert ovenfor;. 2 er en CR-gruppe hvor Rer hydrogen eller et C,.-lineær eller forgrenet alkyl eller en tetrazol-. -yl-gruppe med formel. hvor Rer hydrogen eller C,.-alkyl, med det forbe-hold at når X er CO og R, = H, fenyl eller etyl, er Rforskjellig fra hydrogen eller alkyl.Compounds of formula (I). where. R is C 1-4 linear or branched alkyl. R 1 is hydrogen, C 1-4 linear or branched alkyl. aryl or arylalkyl wherein aryl is phenyl, naphthyl, 2-. thienyl, 2-furanyl, optionally substituted with one or more halogens, C 1-4 alkyl, C 1-4 alkoxy, hydroxy, carboxy or C, .linear or non-. lower alkoxycarbonyl groups; when N and X are connected down a double bond is R 1. of course not present; R 1 is hydrogen, C 1-4 linear or branched alkyl. hydroxy, amino, aryl, wherein aryl is as defined above, or a group of formula NH wherein A is C 1 -C 4 acyl, CN, NO, CONHB or CSNHB where B is. hydrogen, C 1 -C 4 linear or branched alkyl, C cycloalkyl, aryl as defined above; R 1 is hydrogen or one or more halogen atoms; X is CO or a C-R group where R may be OR. (where R 1 must be present and has the above meanings), aryl optionally substituted with carboxy or hydroxy groups or CHOR, where R 1 is hydrogen, lower alkyl, arylalkyl wherein aryl-. elen is as defined above; 2 is a CR group wherein R 1 is hydrogen or a C 1-4 linear or branched alkyl or a tetrazole. -yl group of formula. wherein R 1 is hydrogen or C 1-4 alkyl, with the proviso that when X is CO and R 1 = H, phenyl or ethyl, R is different from hydrogen or alkyl.

NO940321A 1991-08-02 1994-01-31 Compounds with angiotensin II - antagonistic activity NO940321L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI912182A IT1250749B (en) 1991-08-02 1991-08-02 HETEROCYCLIC COMPOUNDS ACTIVATED IN II ANTAGONIST
PCT/EP1992/001753 WO1993003018A1 (en) 1991-08-02 1992-08-03 Compounds having angiotensine ii antagonistic activity

Publications (2)

Publication Number Publication Date
NO940321D0 NO940321D0 (en) 1994-01-31
NO940321L true NO940321L (en) 1994-03-29

Family

ID=26069953

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940321A NO940321L (en) 1991-08-02 1994-01-31 Compounds with angiotensin II - antagonistic activity

Country Status (2)

Country Link
NO (1) NO940321L (en)
RU (1) RU2098411C1 (en)

Also Published As

Publication number Publication date
NO940321D0 (en) 1994-01-31
RU2098411C1 (en) 1997-12-10

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