NO940321L - Compounds with angiotensin II - antagonistic activity - Google Patents
Compounds with angiotensin II - antagonistic activityInfo
- Publication number
- NO940321L NO940321L NO940321A NO940321A NO940321L NO 940321 L NO940321 L NO 940321L NO 940321 A NO940321 A NO 940321A NO 940321 A NO940321 A NO 940321A NO 940321 L NO940321 L NO 940321L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen
- aryl
- linear
- alkyl
- branched alkyl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Forbindelser med formel (I). hvor. R er C,.lineært eller forgrenet alkyl,. R, er hydrogen, C,.lineært eller forgrenet alkyl,. aryl eller arylalkyl hvor aryl er fenyl, naftyl, 2-. tienyl, 2-furanyl, eventuelt substituert med ett eller flere halogener, C,.-alkyl, C,.-alkoksy,. hydroksy, karboksy eller C,.lineære eller forgre-. nede alkoksykarbonylgrupper;. når N og X er forbundet ned en dobbeltbinding er R,. selvfølgelig ikke nærværende;. Rj er hydrogen, C,.-lineær eller forgrenet alkyl,. hydroksy, amino, aryl, hvor aryl er definert som ovenfor, eller en gruppe med formel NHhvor A er Cj-C^acyl, CN, NO, CONHB eller CSNHB hvor B er. hydrogen, C,-Ct-lineær eller forgrenet alkyl, C.-. cykloalkyl, aryl som definert ovenfor;. Rj er hydrogen eller ett eller flere halogenatomer;. X er CO eller en C-R-gruppe hvor Rkan være 0R. (hvor R, må være tilstede og har de ovennevnte betydninger), aryl eventuelt substituert med karboksy- eller hydroksygrupper eller CHOR, hvor Rj er hydrogen, lavere alkyl, arylalkyl hvori aryld-. elen er som definert ovenfor;. 2 er en CR-gruppe hvor Rer hydrogen eller et C,.-lineær eller forgrenet alkyl eller en tetrazol-. -yl-gruppe med formel. hvor Rer hydrogen eller C,.-alkyl, med det forbe-hold at når X er CO og R, = H, fenyl eller etyl, er Rforskjellig fra hydrogen eller alkyl.Compounds of formula (I). where. R is C 1-4 linear or branched alkyl. R 1 is hydrogen, C 1-4 linear or branched alkyl. aryl or arylalkyl wherein aryl is phenyl, naphthyl, 2-. thienyl, 2-furanyl, optionally substituted with one or more halogens, C 1-4 alkyl, C 1-4 alkoxy, hydroxy, carboxy or C, .linear or non-. lower alkoxycarbonyl groups; when N and X are connected down a double bond is R 1. of course not present; R 1 is hydrogen, C 1-4 linear or branched alkyl. hydroxy, amino, aryl, wherein aryl is as defined above, or a group of formula NH wherein A is C 1 -C 4 acyl, CN, NO, CONHB or CSNHB where B is. hydrogen, C 1 -C 4 linear or branched alkyl, C cycloalkyl, aryl as defined above; R 1 is hydrogen or one or more halogen atoms; X is CO or a C-R group where R may be OR. (where R 1 must be present and has the above meanings), aryl optionally substituted with carboxy or hydroxy groups or CHOR, where R 1 is hydrogen, lower alkyl, arylalkyl wherein aryl-. elen is as defined above; 2 is a CR group wherein R 1 is hydrogen or a C 1-4 linear or branched alkyl or a tetrazole. -yl group of formula. wherein R 1 is hydrogen or C 1-4 alkyl, with the proviso that when X is CO and R 1 = H, phenyl or ethyl, R is different from hydrogen or alkyl.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI912182A IT1250749B (en) | 1991-08-02 | 1991-08-02 | HETEROCYCLIC COMPOUNDS ACTIVATED IN II ANTAGONIST |
PCT/EP1992/001753 WO1993003018A1 (en) | 1991-08-02 | 1992-08-03 | Compounds having angiotensine ii antagonistic activity |
Publications (2)
Publication Number | Publication Date |
---|---|
NO940321D0 NO940321D0 (en) | 1994-01-31 |
NO940321L true NO940321L (en) | 1994-03-29 |
Family
ID=26069953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO940321A NO940321L (en) | 1991-08-02 | 1994-01-31 | Compounds with angiotensin II - antagonistic activity |
Country Status (2)
Country | Link |
---|---|
NO (1) | NO940321L (en) |
RU (1) | RU2098411C1 (en) |
-
1992
- 1992-08-03 RU RU9494015173A patent/RU2098411C1/en active
-
1994
- 1994-01-31 NO NO940321A patent/NO940321L/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO940321D0 (en) | 1994-01-31 |
RU2098411C1 (en) | 1997-12-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR200100439T2 (en) | 1H-Imidazopyridine derivatives | |
NZ509045A (en) | Intermediates in the formation of antivirally active heterocyclic azahexane derivatives | |
DK0976748T3 (en) | Pyrrolidine derivatives with phospholipase A2 inhibitory activity | |
HUP0002682A1 (en) | Dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4 | |
LU88621I2 (en) | Sandopril | |
DK1485359T3 (en) | sodium | |
TR200102957T2 (en) | Method for the preparation of citalopram. | |
PL326159A1 (en) | Heterocyclic fungicides | |
DE69529418D1 (en) | CYCLOPROPACHROME CARBONIC ACID DERIVATIVES | |
ATE164844T1 (en) | AZOLE COMPOUNDS, THEIR PRODUCTION AND USE AS ANTIFUNGAL AGENTS | |
ATE72431T1 (en) | 5-MEMBER HETEROCYCLIC ANGIOTENSIN CONVERSION ENZYME INHIBITORS. | |
ES8203354A1 (en) | 1,2,4-Triazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them. | |
NO964551L (en) | Imidazole derivatives and process for their preparation | |
NO961236L (en) | Pyrrolodiazine derivatives as stabilizers for chlorine-containing polymerisates | |
NO921159L (en) | TIAZOLIDINON AND OXSAZOLIDINON DERIVATIVES, PROCEDURES FOR PREPARING THEREOF, AND USING THE DERIVATIVES AS VASODILATORS | |
NO940321L (en) | Compounds with angiotensin II - antagonistic activity | |
DE69813554D1 (en) | CYCLIC UREA AND LACTAM DERIVATIVES OF BENZO (5,6) CYCLOHEPTAPYRIDINES FOR USE AS A FARNESYL PROTEIN TRANSFERASE INHIBITOR | |
AU695633B2 (en) | Arylpiperidine and arylpiperazine derivatives and medicament containing the same | |
DE60108089D1 (en) | HETEROCYCLIC OR BENZOL DERIVATIVES OF LIPONIC ACID, THEIR PREPARATION AND THEIR USE AS CEREALS | |
ES2140524T3 (en) | METOTREXATE DERIVATIVES. | |
TW344743B (en) | Therapeutic nucleosides | |
CA2092919A1 (en) | Epoxysuccinamic acid derivatives | |
AP2001002314A0 (en) | Substituted benzolactam compounds. | |
WO1993004059A1 (en) | 4-acylaminoimidazole derivative | |
NO994104L (en) | 5-hydroxymethyl-2-aminotetralins in the form of cardiovascular agents |