NO934515L - Innskudd-mutasjoner i mycobakterier - Google Patents

Innskudd-mutasjoner i mycobakterier

Info

Publication number
NO934515L
NO934515L NO934515A NO934515A NO934515L NO 934515 L NO934515 L NO 934515L NO 934515 A NO934515 A NO 934515A NO 934515 A NO934515 A NO 934515A NO 934515 L NO934515 L NO 934515L
Authority
NO
Norway
Prior art keywords
mycobacteria
gene
mutant
mutations
deposit
Prior art date
Application number
NO934515A
Other languages
English (en)
Inventor
William R Jacobs
Barry Bloom
Ganjam V Kalpana
Jeffrey D Cirillo
Original Assignee
Einstein Coll Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Einstein Coll Med filed Critical Einstein Coll Med
Publication of NO934515L publication Critical patent/NO934515L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)

Abstract

En mutert mycobakterie valgt fra klassen bestående av nmtert M. bovis-BC, mutert M. tuberculosis og mutert M. lepra er beskrevet. Mutasjon av M.bovls-BCG, M.tubercu- losis eller M. lepra blir fortrinnsvis utført ved innskuddsmutasjon av et mycobakterielt gen. Innskudds- mutagenesen kan for eksempel bli oppnådd ved uriktig rekomblnasjon eller av et myobakterielt transposon. Slike muterte mycobakterier kan deretter bli trans- formert med en ekspressjonsvektor inneholdende et komplementgen for genet som er mutert og fortrinnsvis også et heterologt gen.
NO934515A 1991-06-13 1993-12-09 Innskudd-mutasjoner i mycobakterier NO934515L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71465691A 1991-06-13 1991-06-13
US80670691A 1991-12-12 1991-12-12
PCT/US1992/004706 WO1992022326A1 (en) 1991-06-13 1992-06-02 Insertional mutations in mycobacteria

Publications (1)

Publication Number Publication Date
NO934515L true NO934515L (no) 1994-02-02

Family

ID=27109189

Family Applications (2)

Application Number Title Priority Date Filing Date
NO934515A NO934515L (no) 1991-06-13 1993-12-09 Innskudd-mutasjoner i mycobakterier
NO934515D NO934515D0 (no) 1991-06-13 1993-12-09 Innskudd-mutasjoner i mycobakterier

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO934515D NO934515D0 (no) 1991-06-13 1993-12-09 Innskudd-mutasjoner i mycobakterier

Country Status (7)

Country Link
EP (2) EP0972839A1 (no)
JP (1) JPH06511145A (no)
AU (2) AU2189392A (no)
CA (1) CA2111217A1 (no)
FI (1) FI935566A0 (no)
NO (2) NO934515L (no)
WO (1) WO1992022326A1 (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566121B1 (en) 1991-06-13 2003-05-20 Albert Einstein College Of Medicine Of Yeshiva University Insertional mutations in mycobacteria
AU1097795A (en) 1993-11-23 1995-06-13 Regents Of The University Of California, The Abundant extracellular products and methods for their production and use
US6752993B1 (en) 1993-11-23 2004-06-22 The Regents Of The University Of California Abundant extracellular product vaccines and methods for their production and use
US7300660B2 (en) 1993-11-23 2007-11-27 The Regents Of The University Of California Abundant extracellular products and methods for their production and use
WO1995032277A1 (en) * 1994-05-23 1995-11-30 Albert Einstein College Of Medicine Of Yeshiva University Insertional mutations in mycobacteria
US5843664A (en) * 1996-06-11 1998-12-01 Institut Pasteur Method of selection of allelic exchange mutants
US6013660A (en) * 1996-10-02 2000-01-11 The Regents Of The University Of California Externally targeted prophylactic and chemotherapeutic method and agents
US6221364B1 (en) * 1996-11-12 2001-04-24 Albert Einstein College Of Medicine Of Yeshiva University Recombinant mycobacteria auxotrophic for diaminopimelate
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
WO1999002670A1 (en) * 1997-07-10 1999-01-21 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Method of attenuating pathogenic mycobacteria and strains of mycobacteria so attenuated
US6387694B1 (en) 1998-04-03 2002-05-14 Albert Einstein College Of Medicine Of Yeshiva University Mycobacterial isocitrate lyase gene and uses thereof
US7115730B1 (en) 1999-04-27 2006-10-03 Chiron Srl Immunogenic detoxified mutant E. coli LT-A-toxin
AU2001230912A1 (en) 2000-01-11 2001-07-24 The Board Of Regents Of The University Of Nebraska Identification of virulence determinants
CL2007002710A1 (es) * 2007-09-20 2008-01-04 Univ Pontificia Catolica Chile Formulacion inmunogenica que confiere proteccion contra la infeccion o patologia causada por el virus respiratorio sincicial (vrs) que comprende una cepa recombinante atenuada de mycobacterium; y uso de la formulacion inmunogenica para preparar una vacuna para prevenir, tratar o atenuar infecciones del vrs.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0681026A1 (en) * 1987-03-02 1995-11-08 Whitehead Institute For Biomedical Research Recombinant mycobacterial vaccine
US5504005A (en) * 1987-03-02 1996-04-02 Albert Einstein College Of Medicine Of Yeshiva University Recombinant mycobacterial vaccine
AU5848090A (en) * 1989-06-19 1991-01-08 Whitehead Institute For Biomedical Research Vector-mediated genomic insertion and expression of dna in bcg
CA2045842A1 (en) * 1990-07-16 1992-01-17 William R. Jacobs Dna capable of site-specific integration into mycobacteria

Also Published As

Publication number Publication date
NO934515D0 (no) 1993-12-09
CA2111217A1 (en) 1992-12-23
AU2189392A (en) 1993-01-12
EP0972839A1 (en) 2000-01-19
WO1992022326A1 (en) 1992-12-23
EP0590027A4 (en) 1994-10-19
AU1635797A (en) 1997-06-12
FI935566A (fi) 1993-12-10
EP0590027A1 (en) 1994-04-06
FI935566A0 (fi) 1993-12-10
JPH06511145A (ja) 1994-12-15

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