NO931671L - DEPOT-PREPARATION - Google Patents

DEPOT-PREPARATION

Info

Publication number
NO931671L
NO931671L NO93931671A NO931671A NO931671L NO 931671 L NO931671 L NO 931671L NO 93931671 A NO93931671 A NO 93931671A NO 931671 A NO931671 A NO 931671A NO 931671 L NO931671 L NO 931671L
Authority
NO
Norway
Prior art keywords
oxepino
pyrrole
tetrahydro
trans
chloro
Prior art date
Application number
NO93931671A
Other languages
Norwegian (no)
Other versions
NO931671D0 (en
Inventor
Petrus Johannes Maria Oetelaar
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of NO931671D0 publication Critical patent/NO931671D0/en
Publication of NO931671L publication Critical patent/NO931671L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Hemipamoat eller pamoatsalt av trans-5-klor-2-metyl-2,3,3a,12b-tetrahydro-lH-dibenz-[ 2 , 3 ; 6 , 7 ]oksepino-[4,5-c]pyrrol, er meget uløslige forbindelser med fremragende egenskaper for bruk som depot-preparater. Det beskrives også farmasøytiske preparater som inneholder pamoatsaltene av trans-5-klor-2-metyl-2,3,3a,12b-tetrahydro-lH-dibenz[2,3:6,7]-oksepino-[4,5-c]pyrrol, spesielt i krystallinsk form. Slike preparater frigjør terapeutiske anvendelige mengder av trans-5-klor-2-metyl-2,3,3a,12b-tetrahydro-lH-dibenz[2,3:6,7]-oksepino-[4,5-c]pyrrol i 2 til 6 uker etter administrering.Oppfinnelsen innbefatter også fremgangsmåter for fremstilling av de farmasøytiske preparater som generelt innbefatter at en fri base av trans-5-klor-2-metyl-2,3-3a,12b-tetrahydro-lH-dibenz-[2,3:6,7]oksepino[4,5-c]pyrrol får reagere med pamoinsyre og danne et pamoat eller hemipamoatsalt.Hemipamoate or pamoate salt of trans-5-chloro-2-methyl-2,3,3a, 12b-tetrahydro-1H-dibenz- [2,3; 6, 7] oxepino- [4,5-c] pyrrole, are very insoluble compounds with excellent properties for use as depot preparations. Also described are pharmaceutical compositions containing the pamoate salts of trans-5-chloro-2-methyl-2,3,3a, 12b-tetrahydro-1H-dibenz [2,3: 6,7] -oxepino- [4,5-c ] pyrrole, especially in crystalline form. Such preparations release therapeutically useful amounts of trans-5-chloro-2-methyl-2,3,3a, 12b-tetrahydro-1H-dibenz [2,3: 6,7] -oxepino- [4,5-c] pyrrole The invention also includes processes for the preparation of the pharmaceutical compositions which generally include a free base of trans-5-chloro-2-methyl-2,3-3a, 12b-tetrahydro-1H-dibenzene. [2,3: 6,7] oxepino [4,5-c] pyrrole is allowed to react with pamoic acid to form a pamoate or hemipamoate salt.

NO93931671A 1992-05-08 1993-05-07 DEPOT-PREPARATION NO931671L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92201319 1992-05-08

Publications (2)

Publication Number Publication Date
NO931671D0 NO931671D0 (en) 1993-05-07
NO931671L true NO931671L (en) 1993-11-09

Family

ID=8210598

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93931671A NO931671L (en) 1992-05-08 1993-05-07 DEPOT-PREPARATION

Country Status (8)

Country Link
JP (1) JPH0656840A (en)
KR (1) KR930023338A (en)
AU (1) AU3846293A (en)
CA (1) CA2095499A1 (en)
FI (1) FI932088A (en)
MX (1) MX9302711A (en)
NO (1) NO931671L (en)
ZA (1) ZA933134B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122010000050I2 (en) * 1994-03-02 2011-07-21 Organon Nv Sublingual or buccal medicine.
DK1468689T3 (en) * 1998-09-30 2007-08-13 Lilly Co Eli 2-methyl-thieno-benzodiazepine formulation
DE10041479A1 (en) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh New pharmaceutical composition for the administration of N-0923
GB0216416D0 (en) * 2002-07-15 2002-08-21 Novartis Ag Organic compounds
US6987111B2 (en) * 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
MX2012000061A (en) * 2009-06-24 2012-06-01 Msd Oss Bv Injectable formulations containing asenapine and method of treatment using same.
JP2021014404A (en) * 2017-10-13 2021-02-12 アステラス製薬株式会社 Triazolopyrazine derivative salt and crystal

Also Published As

Publication number Publication date
KR930023338A (en) 1993-12-18
FI932088A (en) 1993-11-09
ZA933134B (en) 1993-11-30
CA2095499A1 (en) 1993-11-09
AU3846293A (en) 1993-11-11
FI932088A0 (en) 1993-05-07
NO931671D0 (en) 1993-05-07
MX9302711A (en) 1994-05-31
JPH0656840A (en) 1994-03-01

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