NO924140L - OLIGONUCLEOTIDE MODULATION OF ARACHIDONIC ACID METABOLISM - Google Patents

OLIGONUCLEOTIDE MODULATION OF ARACHIDONIC ACID METABOLISM

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Publication number
NO924140L
NO924140L NO92924140A NO924140A NO924140L NO 924140 L NO924140 L NO 924140L NO 92924140 A NO92924140 A NO 92924140A NO 924140 A NO924140 A NO 924140A NO 924140 L NO924140 L NO 924140L
Authority
NO
Norway
Prior art keywords
oligonucleotide
phospholipase
metabolism
arachidonic acid
methods
Prior art date
Application number
NO92924140A
Other languages
Norwegian (no)
Other versions
NO924140D0 (en
Inventor
Clarence Frank Bennett
David J Ecker
Stanley T Crooke
Christopher K Mirabelli
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1991/002628 external-priority patent/WO1991016901A1/en
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of NO924140D0 publication Critical patent/NO924140D0/en
Publication of NO924140L publication Critical patent/NO924140L/en

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Abstract

Sammensetninger og fremgangsmåter er tilveiebragt for behandling og diagnostikk av sykdommer som kan under- kastes modulering av syntesen eller metabolismen av arachldonsyre og beslektede forbindelser. I henhold til foretrukne utfarelsesformer er ollgonuleotider og ollgonukleotldanaloger tilveiebragt som er spesifikt hybrldlserbare med nuklelnsyrer kodende for 5-lipoksy- genase, 5-llpoksygenase-aktlverende proteiner, LTA4 -hydrolase, fosfollpase A£> fosfolipase C og co-enzym A- uavhengig transacylase. Ollgonukleotld omfatter ollgonukleotldenheter som er tilstrekkelige i identitet og antall for å tilveiebringe nevnte spesifikke hybrldisering. I andre foretrukne utfarelsesformer er- ollgonukleotldene spesifikt hybrldlserbare med et transkrlpsjonsinitlerlngssete, et translasjonslnitler- ingssete og intron/ekson grensen. Fremgangsmåter for behandling av dyr som lider av sykdom som kan utsettes for terapeutisk Intervensjon ved modulering av arachi- donsyre-syntesen eller metabolismen med et oligonukleo- tid eller en oligonukleotldanalog spesifikt hybridiser- bar med RNA eller DNA tilsvarende en av de foregående proteinene er beskrevet. Fremgangsmåter for behandling av sykdommer som reagerer overfor modulering av arachidonsyre-syntesen eller metabolismen er beskrevet.Compositions and methods are provided for the treatment and diagnosis of diseases which may be subject to modulation of the synthesis or metabolism of arachldonic acid and related compounds. According to preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with nucleic acids encoding 5-lipoxygenase, 5-11oxyoxygenase activating proteins, LTA4 phospholipase A phospholipase A phospholipase A phospholipase A The oligonucleotide comprises oligonucleotide units sufficient in identity and number to provide said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translational mediation site, and the intron / exon boundary. Methods for treating animals suffering from disease that may be subjected to therapeutic intervention by modulating arachidonic acid synthesis or metabolism with an oligonucleotide or an oligonucleotide analog specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are described. Methods for treating diseases responsive to modulation of arachidonic acid synthesis or metabolism are described.

NO92924140A 1990-04-30 1992-10-27 OLIGONUCLEOTIDE MODULATION OF ARACHIDONIC ACID METABOLISM NO924140L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51696990A 1990-04-30 1990-04-30
PCT/US1991/002628 WO1991016901A1 (en) 1990-04-30 1991-04-17 Oligonucleotide modulation of arachidonic acid metabolism

Publications (2)

Publication Number Publication Date
NO924140D0 NO924140D0 (en) 1992-10-27
NO924140L true NO924140L (en) 1992-12-11

Family

ID=26783090

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92924140A NO924140L (en) 1990-04-30 1992-10-27 OLIGONUCLEOTIDE MODULATION OF ARACHIDONIC ACID METABOLISM

Country Status (2)

Country Link
FI (1) FI924915A0 (en)
NO (1) NO924140L (en)

Also Published As

Publication number Publication date
FI924915A (en) 1992-10-29
NO924140D0 (en) 1992-10-27
FI924915A0 (en) 1992-10-29

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