NO923939L - ANTI-ENDOTOKSINFORBINDELSER - Google Patents

ANTI-ENDOTOKSINFORBINDELSER

Info

Publication number
NO923939L
NO923939L NO92923939A NO923939A NO923939L NO 923939 L NO923939 L NO 923939L NO 92923939 A NO92923939 A NO 92923939A NO 923939 A NO923939 A NO 923939A NO 923939 L NO923939 L NO 923939L
Authority
NO
Norway
Prior art keywords
endotoksinforbindelser
Prior art date
Application number
NO92923939A
Other languages
Norwegian (no)
Other versions
NO180491C (en
NO923939D0 (en
NO180491B (en
Inventor
William J Christ
Lynn D Hawkins
Osamu Asano
Tsutomu Kawata
Seiichi Kobayashi
Daniel P Rossignol
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/935,050 external-priority patent/US5530113A/en
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO923939D0 publication Critical patent/NO923939D0/en
Publication of NO923939L publication Critical patent/NO923939L/en
Publication of NO180491B publication Critical patent/NO180491B/en
Publication of NO180491C publication Critical patent/NO180491C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
NO923939A 1991-10-11 1992-10-09 Anti-endotoxin compounds, their intermediates, a pharmaceutical composition containing them, a process for coupling an alkyl side chain to an azidosaccharide having a free hydroxyl, and using said compounds NO180491C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77610091A 1991-10-11 1991-10-11
US07/935,050 US5530113A (en) 1991-10-11 1992-08-25 Anti-endotoxin compounds

Publications (4)

Publication Number Publication Date
NO923939D0 NO923939D0 (en) 1992-10-09
NO923939L true NO923939L (en) 1993-04-13
NO180491B NO180491B (en) 1997-01-20
NO180491C NO180491C (en) 1997-04-30

Family

ID=27119147

Family Applications (1)

Application Number Title Priority Date Filing Date
NO923939A NO180491C (en) 1991-10-11 1992-10-09 Anti-endotoxin compounds, their intermediates, a pharmaceutical composition containing them, a process for coupling an alkyl side chain to an azidosaccharide having a free hydroxyl, and using said compounds

Country Status (12)

Country Link
US (3) US5756718A (en)
EP (1) EP0536969A3 (en)
JP (1) JP3865411B2 (en)
CN (1) CN1071668A (en)
AU (1) AU660325B2 (en)
CA (1) CA2079971A1 (en)
FI (1) FI924579A (en)
HU (1) HUT64538A (en)
IL (1) IL103298A0 (en)
NO (1) NO180491C (en)
NZ (1) NZ244643A (en)
RU (1) RU2095366C1 (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530113A (en) * 1991-10-11 1996-06-25 Eisai Co., Ltd. Anti-endotoxin compounds
AU660325B2 (en) * 1991-10-11 1995-06-22 Eisai Co. Ltd. Anti-endotoxin compounds and related molecules and methods
US5648343A (en) * 1994-02-28 1997-07-15 The University Of Georgia Research Foundation Method for treating LPS-mediated disorders
US5681824A (en) 1995-06-05 1997-10-28 Eisai Co., Ltd. Substituted liposaccharides useful in the treatment and prevention of endotoxemia
US6417172B1 (en) * 1995-06-05 2002-07-09 Eisai Co., Ltd. Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs
US5952309A (en) * 1995-09-29 1999-09-14 Eisai Company, Ltd. Method for treating alcoholic liver disease
CN1150001C (en) * 1996-07-03 2004-05-19 卫材株式会社 Injections contg. lipid A analogues and process for preparation thereof
AU7799198A (en) * 1997-05-23 1998-12-21 Eisai Co. Ltd. Method for preparing pharmaceutical formulation
US6368604B1 (en) 1997-09-26 2002-04-09 University Of Maryland Biotechnology Institute Non-pyrogenic derivatives of lipid A
EP1111390A4 (en) 1998-09-01 2007-11-14 Eisai R&D Man Co Ltd Method for evaluating lipid a analog-containing injections
WO2000042994A2 (en) * 1999-01-21 2000-07-27 North Shore-Long Island Jewish Research Institute Inhibition of bacterial dissemination
US20040006242A1 (en) 1999-02-01 2004-01-08 Hawkins Lynn D. Immunomodulatory compounds and method of use thereof
CZ20012919A3 (en) 1999-02-10 2002-03-13 Sankyo Company, Limited Ether type lipid A1-carboxylic acid analogues
US7491707B1 (en) 1999-11-15 2009-02-17 Biomira, Inc. Synthetic lipid-a-analogs and uses thereof
US6861512B2 (en) 2000-03-01 2005-03-01 Eisai Co., Ltd. Separation of olefinic isomers
AU2001246858A1 (en) * 2000-04-06 2001-10-23 Sankyo Company Limited 1-carboxymethyl analogues of lipid a
MXPA02011486A (en) * 2000-05-19 2004-01-26 Corixa Corp Prophylactic and therapeutic treatment of infectious and other diseases with mono and disaccharide based compounds.
US20020042379A1 (en) * 2000-06-09 2002-04-11 Daniel Rossignol Administration of an anti-endotoxin drug by bolus or intermittent intravenous infusion
US20030105033A1 (en) 2000-06-09 2003-06-05 Rossignol Daniel P. Administration of an anti-endotoxin drug by bolus or intermittent intravenous infusion
US20040198652A1 (en) * 2001-04-24 2004-10-07 Carter J. Paul Methods and compositions for preventing and treating septic shock and endotoxemia
WO2002088156A1 (en) * 2001-04-26 2002-11-07 Sankyo Company, Limited Lipid a 1-carboxylic acid derivative
EP1420798A4 (en) 2001-08-10 2007-07-25 Eisai Co Ltd Treatment and prevention of heat shock protein-associated diseases and conditions
WO2004058788A1 (en) * 2002-12-24 2004-07-15 Sankyo Company, Limited Lipid a analogues having glucose as the right sugar
US7906633B2 (en) * 2003-02-20 2011-03-15 Eisai R&D Management Co., Ltd. Reagents and methods for preparing LPS antagonist B1287 and stereoisomers thereof
US7951232B2 (en) * 2006-02-09 2011-05-31 Elevance Renewable Sciences, Inc. Surface coating compositions and methods
MX2008010359A (en) * 2006-02-09 2009-01-30 Elevance Renewable Sciences Antimicrobial compositions, methods and systems.
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
ES2673046T3 (en) 2006-09-26 2018-06-19 Infectious Disease Research Institute Vaccine composition containing a synthetic adjuvant
US8518903B2 (en) 2007-04-19 2013-08-27 University of Pittsburgh—of the Commonwealth System of Higher Education Use of toll-like receptor-9 agonists
CA2764374C (en) 2009-06-05 2019-11-19 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
US10668092B2 (en) 2010-09-24 2020-06-02 The John Hopkins University Compositions and methods for treatment of inflammatory disorders
US9072760B2 (en) 2010-09-24 2015-07-07 University of Pittsburgh—of the Commonwealth System of Higher Education TLR4 inhibitors for the treatment of human infectious and inflammatory disorders
WO2012088425A2 (en) 2010-12-22 2012-06-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Gap junction-enhancing agents for treatment of necrotizing enterocolitis and inflammatory bowel disease
CN103596586A (en) 2011-04-08 2014-02-19 免疫设计公司 Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
CN107540730B (en) 2012-05-16 2021-07-16 免疫设计公司 Vaccines for HSV-2
US9562066B2 (en) 2012-09-25 2017-02-07 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Oral therapy of necrotizing enterocolitis
EA032326B1 (en) 2013-04-18 2019-05-31 Иммьюн Дизайн Корп. Gla monotherapy for use in cancer treatment
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
RU2564918C1 (en) * 2014-05-07 2015-10-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Оренбургская государственная медицинская академия" Министерства здравоохранения Российской Федерации /ГБОУ ВПО ОрГМА Минздрава России/ Agent for reducing systemic pathologic endotoxinemia
EP3522893A4 (en) * 2016-10-04 2020-08-26 University Of Maryland, Baltimore Methods of treating sepsis using anti-sepsis lipid a (asla) based therapeutics
CN114315893B (en) * 2021-12-22 2023-08-25 科之杰新材料集团有限公司 Quaternary ammonium salt functional monomer and preparation method thereof, high-adaptability polycarboxylic acid slump retaining agent and preparation method thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495346A (en) * 1981-03-30 1985-01-22 Wisconsin Alumni Research Foundation Method of preparing a disaccharide
US5057598A (en) * 1983-05-06 1991-10-15 Centocor, Inc. Monoclonal antibodies reactive with endotoxin core
US4629722A (en) * 1984-07-12 1986-12-16 Ribi Immunochem Research, Inc. Method of inhibiting the onset of acute radiation syndrome
US4844894A (en) * 1984-07-12 1989-07-04 Ribi Immunochem Research Inc. Method of inhibiting the onset of septicemia and endotoxemia
US5066794A (en) * 1984-08-24 1991-11-19 Daiichi Pharmaceutical Co., Ltd. Process for preparing a disaccharide derivative
JPS6153295A (en) * 1984-08-24 1986-03-17 Dai Ichi Seiyaku Co Ltd Disaccharide derivative
NL8601551A (en) * 1985-06-28 1987-01-16 Sandoz Ag NEW SACCHARIDES, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US4918163A (en) * 1985-09-27 1990-04-17 Pfizer Inc. Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria
US4877611A (en) * 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4929604A (en) * 1986-05-28 1990-05-29 Board Of Regents, The University Of Texas System Lipopolysaccharides of reduced toxicity and the production thereof
JP2535048B2 (en) * 1988-02-29 1996-09-18 第一製薬株式会社 Novel disaccharide derivative and its salt
US5134230A (en) * 1988-03-02 1992-07-28 Daiichi Pharmaceutical Co., Ltd. 2-Deoxy-2-aminoglucopyranoside derivatives
ZA881430B (en) * 1988-03-02 1988-10-28
IL90388A (en) * 1988-05-26 1993-08-18 Duphar Int Res Pharmaceutical compositions having anti- endotoxic activity containing a novel active fraction from lactulose syrup, and a method for its preparation
US4912094B1 (en) * 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5158939A (en) 1989-07-21 1992-10-27 Wisconsin Alumni Research Foundation Method of stimulating the immune systems of animals and compositions useful therefor
US5041427A (en) * 1989-07-21 1991-08-20 Wisconsin Alumni Research Foundation Lipid A derivatives
JPH0655749B2 (en) * 1989-09-20 1994-07-27 日本たばこ産業株式会社 Lipid A monosaccharide analog
JP2839916B2 (en) * 1989-10-20 1998-12-24 三共株式会社 Lipid A 3-position ether analogue
US5158941A (en) * 1990-06-08 1992-10-27 E. I. Du Pont De Nemours And Company Lipid A analog as stimulant for production of interleukin-1 in human monocytes and tumor cell growth inhibitor
AU660325B2 (en) * 1991-10-11 1995-06-22 Eisai Co. Ltd. Anti-endotoxin compounds and related molecules and methods
IL105131A (en) * 1992-03-27 2000-06-01 Igen Inc Compounds and compositions containing such compounds comprising lipid-A analogs for eliciting therapeutic antibodies

Also Published As

Publication number Publication date
NO180491C (en) 1997-04-30
FI924579A0 (en) 1992-10-09
NO923939D0 (en) 1992-10-09
US5612476A (en) 1997-03-18
AU2526692A (en) 1993-04-22
US5756718A (en) 1998-05-26
FI924579A (en) 1993-04-12
NZ244643A (en) 1995-07-26
EP0536969A2 (en) 1993-04-14
CN1071668A (en) 1993-05-05
IL103298A0 (en) 1993-02-21
NO180491B (en) 1997-01-20
EP0536969A3 (en) 1994-05-18
JP3865411B2 (en) 2007-01-10
CA2079971A1 (en) 1993-04-12
AU660325B2 (en) 1995-06-22
HUT64538A (en) 1994-01-28
RU2095366C1 (en) 1997-11-10
US5843918A (en) 1998-12-01
HU9203204D0 (en) 1992-12-28
JPH05194470A (en) 1993-08-03

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