NO923240L - NEW HEPARIN DERIVATIVES - Google Patents

NEW HEPARIN DERIVATIVES

Info

Publication number
NO923240L
NO923240L NO92923240A NO923240A NO923240L NO 923240 L NO923240 L NO 923240L NO 92923240 A NO92923240 A NO 92923240A NO 923240 A NO923240 A NO 923240A NO 923240 L NO923240 L NO 923240L
Authority
NO
Norway
Prior art keywords
heparin derivatives
treating
approximately
temperature
heparin
Prior art date
Application number
NO92923240A
Other languages
Norwegian (no)
Other versions
NO923240D0 (en
Inventor
Francesco Della Valle
Aurelio Romeo
Guenter Kirschner
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of NO923240D0 publication Critical patent/NO923240D0/en
Publication of NO923240L publication Critical patent/NO923240L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Lav-molekylvekt heparinderivater og salter derav er fremstilt ved behandling av et kvaternært ammoniumsalt av et heparin, opplest i et heterosyklisk organisk opplesningsmiddel eller i et aprotisk opplesningsmiddel, ned et alkylerende middel, som har fra 6-30 karbonatomer, ved en temperatur på tilnærmet 20°-60°C, i en forlenget tidsperiode, og behandling av det resulterende reaksjonsprodukt, ved en temperatur på tilnærmet 5e-120°C, med en uorganisk eller organisk base, såsom et alkalisk hydroksid, i vandig opplesning, og isolering av de oppnådde heparinderi- vater i sin frie form eller som et alkalisk salt derav. Heparinderivatene oppnådd i henhold til fremgangsmåten i den foreliggende oppfinnelse utgjør en blanding av for det meste depolymeriserte produkter med molekylvekter innenfor et trangt område. Disse produkter er nyttige som antitrombotiske midler.Low molecular weight heparin derivatives and salts thereof are prepared by treating a quaternary ammonium salt of a heparin, dissolved in a heterocyclic organic solvent or in an aprotic solvent, down an alkylating agent having from 6-30 carbon atoms at a temperature of approximately 20 ° -60 ° C, for an extended period of time, and treating the resulting reaction product, at a temperature of approximately 5e-120 ° C, with an inorganic or organic base, such as an alkaline hydroxide, in aqueous solution, and isolating the obtained heparin derivatives in their free form or as an alkaline salt thereof. The heparin derivatives obtained according to the process of the present invention comprise a mixture of mostly depolymerized products with molecular weights within a narrow range. These products are useful as antithrombotic agents.

NO92923240A 1990-12-20 1992-08-18 NEW HEPARIN DERIVATIVES NO923240L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT04175290A IT1243300B (en) 1990-12-20 1990-12-20 HEPARIN DERIVATIVES
PCT/EP1991/002479 WO1992011294A1 (en) 1990-12-20 1991-12-20 Heparin derivatives

Publications (2)

Publication Number Publication Date
NO923240D0 NO923240D0 (en) 1992-08-18
NO923240L true NO923240L (en) 1992-10-19

Family

ID=11253436

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92923240A NO923240L (en) 1990-12-20 1992-08-18 NEW HEPARIN DERIVATIVES

Country Status (13)

Country Link
EP (1) EP0516792A1 (en)
JP (1) JPH05504785A (en)
KR (1) KR920703644A (en)
CN (1) CN1062537A (en)
AU (1) AU658594B2 (en)
BR (1) BR9106234A (en)
CA (1) CA2075970A1 (en)
FI (1) FI923762A0 (en)
HU (1) HUT62917A (en)
IT (1) IT1243300B (en)
NO (1) NO923240L (en)
PT (1) PT99898A (en)
WO (1) WO1992011294A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663639B1 (en) * 1990-06-26 1994-03-18 Rhone Poulenc Sante LOW MOLECULAR WEIGHT POLYSACCHARIDE BLENDS PROCESS FOR PREPARATION AND USE.
FR2704861B1 (en) * 1993-05-07 1995-07-28 Sanofi Elf Purified heparin fractions, process for obtaining them and pharmaceutical compositions containing them.
ES2077533B1 (en) * 1994-02-28 1996-07-01 Bioiberica PROCEDURE FOR OBTAINING OLIGOSACCHARIDE FRACTIONS BY CHEMICAL DEPOLYMERIZATION OF HEPARIN.
US5639469A (en) * 1994-06-15 1997-06-17 Minnesota Mining And Manufacturing Company Transmucosal delivery system
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
AU1735097A (en) * 1996-03-15 1997-10-01 Takara Shuzo Co., Ltd. A product of heat treatment of uronic acid, food, drink or drug including the product
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
FR2763848B1 (en) * 1997-05-28 2000-01-28 Rhone Poulenc Rorer Sa USE OF LOW MOLECULAR WEIGHT HEPARINS FOR THE PREVENTION AND TREATMENT OF CENTRAL NERVOUS TRAUMA
JP4599604B2 (en) * 2002-04-19 2010-12-15 カーギル テクスチュアライジング ソリューションズ ドイチュラント ゲゼルシャフト ミット ベシュレクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト Matrix containing bioactive phospholipid-containing components
DE10217557A1 (en) * 2002-04-19 2003-11-06 Degussa Bioactives Gmbh Functional foods containing a phospholipid-containing stable matrix
CN100335506C (en) * 2004-05-20 2007-09-05 汕头市金丰医疗器械科技有限公司 Heparin compound, and its preparing method and use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2482603A1 (en) * 1980-05-14 1981-11-20 Pharmindustrie NOVEL HEPARIN ESTERS FOR USE IN THE PREPARATION OF MEDICAMENTS, AND METHODS FOR THEIR PREPARATION
DE3751275T2 (en) * 1986-08-20 1995-09-07 Univ Miami Low molecular weight alkyl esters of heparin.
SE8702254D0 (en) * 1987-05-29 1987-05-29 Kabivitrum Ab NOVEL HEPARIN DERIVATIVES

Also Published As

Publication number Publication date
IT1243300B (en) 1994-05-26
CA2075970A1 (en) 1992-06-21
EP0516792A1 (en) 1992-12-09
IT9041752A0 (en) 1990-12-20
IT9041752A1 (en) 1992-06-21
AU658594B2 (en) 1995-04-27
WO1992011294A1 (en) 1992-07-09
JPH05504785A (en) 1993-07-22
PT99898A (en) 1992-12-31
HUT62917A (en) 1993-06-28
CN1062537A (en) 1992-07-08
FI923762A (en) 1992-08-20
KR920703644A (en) 1992-12-18
NO923240D0 (en) 1992-08-18
BR9106234A (en) 1993-03-30
AU9096491A (en) 1992-07-22
FI923762A0 (en) 1992-08-20

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