NO921406L - GEM DYPHOSPHONIC ACIDS, PROCEDURES IN THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

GEM DYPHOSPHONIC ACIDS, PROCEDURES IN THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
NO921406L
NO921406L NO92921406A NO921406A NO921406L NO 921406 L NO921406 L NO 921406L NO 92921406 A NO92921406 A NO 92921406A NO 921406 A NO921406 A NO 921406A NO 921406 L NO921406 L NO 921406L
Authority
NO
Norway
Prior art keywords
alkyl
chain
hydrogen
phenyl
acids
Prior art date
Application number
NO92921406A
Other languages
Norwegian (no)
Other versions
NO921406D0 (en
Inventor
Sergio Tognella
Valeria Livi
Ernesto Menta
Silvano Spinneli
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT22004A external-priority patent/IT1241674B/en
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Publication of NO921406L publication Critical patent/NO921406L/en
Publication of NO921406D0 publication Critical patent/NO921406D0/en

Links

Abstract

Difosfonsyrer med formel (I) (A) 3 N-(C)-CK-C-N¿ (B) |l O II O U.-V .j_ ¿OR-, hvor R! og R2 er hydrogen eller C1-C4-alkyl; (A) er hydrogen, halogen, hydroksy eller C1-C12~ alkyl; (B) er en binding, en C^-Cg-alkylenkjede, en cyklo- alkylalkylenkjede, en alkylenkjede substituert med cykloheksyl eller cyklopentylgrupper, eller en aralkylkjede, en alkylkjede som inneholder et heteroatom (O, S eller N-CH3) eller en ureidorest - (CH2)ni-NHCONH-(CH2)n-, hvor n varierer fra l til 5, R3 er hydrogen, C^-Cg-alkyl, C3-C6-cykloalkyl, benzyl, fenyl eller p-metoksybenzyl; (C) er Ci-Cs-alkyl, fenyl eller en aralkylkjede; R4 er hydrogen, C1-C4-alkyl eller en aminogruppe eventuelt substituert med alkyl, fenyl, benzyl, p- metoksybenzyl, acyl, aminoeddiksyre- eller pep- tidgrupper, R5 og R6 er 2-halogenetyl eller de danner sammen en 1-aziridinylrest, er nyttige som atitumormidler.Diphosphonic acids of formula (I) (A) 3 N- (C) -CK-C-N¿ (B) | l O II O U.-V .j_ ¿OR-, where R! and R 2 is hydrogen or C 1 -C 4 alkyl; (A) is hydrogen, halogen, hydroxy or C1-C12 alkyl; (B) is a bond, a C1-C8 alkylene chain, a cycloalkylalkylene chain, an alkylene chain substituted by cyclohexyl or cyclopentyl groups, or an aralkyl chain, an alkyl chain containing a heteroatom (O, S or N-CH3) or a ureido residue - (CH2) nI-NHCONH- (CH2) n-, where n varies from 1 to 5, R3 is hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, benzyl, phenyl or p-methoxybenzyl; (C) is C 1 -C 6 alkyl, phenyl or an aralkyl chain; R 4 is hydrogen, C 1 -C 4 alkyl or an amino group optionally substituted with alkyl, phenyl, benzyl, p-methoxybenzyl, acyl, aminoacetic acid or peptide groups, R 5 and R 6 are 2-haloethyl or together form a 1-aziridinyl residue, are useful as atitum agents.

NO921406A 1989-10-12 1992-04-09 GEM DYPHOSPHONIC ACIDS, PROCEDURES IN THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM NO921406D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22004A IT1241674B (en) 1989-10-12 1989-10-12 GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
PCT/EP1990/001710 WO1991005791A1 (en) 1989-10-12 1990-10-11 Gem-diphosphonic acids, a process for the preparation thereof and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
NO921406L true NO921406L (en) 1992-04-09
NO921406D0 NO921406D0 (en) 1992-04-09

Family

ID=26069802

Family Applications (1)

Application Number Title Priority Date Filing Date
NO921406A NO921406D0 (en) 1989-10-12 1992-04-09 GEM DYPHOSPHONIC ACIDS, PROCEDURES IN THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (1)

Country Link
NO (1) NO921406D0 (en)

Also Published As

Publication number Publication date
NO921406D0 (en) 1992-04-09

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