NO920463L - INDOLE-DERIVATIVES - Google Patents

INDOLE-DERIVATIVES

Info

Publication number
NO920463L
NO920463L NO92920463A NO920463A NO920463L NO 920463 L NO920463 L NO 920463L NO 92920463 A NO92920463 A NO 92920463A NO 920463 A NO920463 A NO 920463A NO 920463 L NO920463 L NO 920463L
Authority
NO
Norway
Prior art keywords
carbon atoms
alkyl
atom
forms
hydrogen atom
Prior art date
Application number
NO92920463A
Other languages
Norwegian (no)
Other versions
NO920463D0 (en
Inventor
Hiroshi Nagase
Akira Mizusuna
Yoshihiro Onoda
Koji Kawai
Shu Matsumoto
Takashi Endo
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1991/000759 external-priority patent/WO1991018901A1/en
Application filed by Toray Industries filed Critical Toray Industries
Publication of NO920463D0 publication Critical patent/NO920463D0/en
Publication of NO920463L publication Critical patent/NO920463L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen angår indol-derivater med den generelle formel (l) hvor i^ står for alkyl med l til 5 karbonatomer, cykloalkyl- aikyl med 4 til 7 karbonatomer, cykloalkenylalkyl med 5 til 7 karbonatomer, aralkyl med 7 til 14 karbonatomer, trans-alkenyl med 4 eller 5 karbonatomer, allyl, furanyl-2-ylalkyl med l til 5 karbonatomer, tienyl-2-ylalkyl med l til 5 karbonatomer, vinyloksykarbonyl, trikloretoksykarbonyl, benzyloksykarbonyl, alkanoyl med l til 5 karbonatomer, aralkylkarbonyl med 7 til 14 karbonatomer, 2-furoyl, tiofen-2-karbonyl, cykloalkyl- karbonyl med 4 til 7 karbonatomer, alkenylkarbonyl med 3 ril 8 karbonatomer, eller anisoyl, P-2 står for et hydrogenatom, alkyl med l til 3 karbonatomer, benzyl, eller alkanoyl med 1 til 5 karbonatomer, R, .står for et hydrogenatom, et fluoratom, et kloratom, et bromatom, nitrc, eller alkyl med l til 5 karbonatomer, F:^ srår for BU hydrogenatom, alkyl med I ril 5 karsoriarcmer, -benzyl eller fenyl, og F., står for et hydrocen- atorr., hydroksy, eller alkanoyloksy med l til 5 karbonatomer, ider nevr.te generelle fcrrr;el (1) c~fatrer (+)-f ormer, (-)- former og (r)-former, eller er farmakologisk akseptabelt salr derav, samt immunosuppressive midler som har indol-derivatet, eller et farmakologisk akseptabelt salt derav, som virkestoff.The invention relates to indole derivatives of the general formula (I) wherein I represents alkyl of 1 to 5 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, cycloalkenylalkyl of 5 to 7 carbon atoms, aralkyl of 7 to 14 carbon atoms, trans-alkenyl with 4 or 5 carbon atoms, allyl, furanyl-2-ylalkyl of 1 to 5 carbon atoms, thienyl-2-ylalkyl of 1 to 5 carbon atoms, vinyloxycarbonyl, trichloroethoxycarbonyl, benzyloxycarbonyl, alkanoyl of 1 to 5 carbon atoms, aralkyl carbonyl of 7 to 14 2-furoyl, thiophene-2-carbonyl, cycloalkylcarbonyl of 4 to 7 carbon atoms, alkenylcarbonyl of 3 to 8 carbon atoms, or anisoyl, P-2 represents a hydrogen atom, alkyl of 1 to 3 carbon atoms, benzyl, or alkanoyl of 1 for 5 carbon atoms, R 1 stands for a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, nitrc, or alkyl of 1 to 5 carbon atoms, F: 5 substitutes for a BU hydrogen atom, alkyl of 1 to 5 carbons, benzyl or phenyl , and F., stands for a hydrocene atom, hy dioxide, or alkanoyloxy of 1 to 5 carbon atoms, of the general general forms; (1) cis-fatty (+) forms, (-) forms and (r) forms, or are pharmacologically acceptable salts thereof, as well as immunosuppressants having the indole derivative, or a pharmacologically acceptable salt thereof, as active ingredient.

NO92920463A 1990-06-05 1992-02-04 INDOLE-DERIVATIVES NO920463L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP14817990 1990-06-05
JP33545890 1990-11-29
PCT/JP1991/000759 WO1991018901A1 (en) 1990-06-05 1991-06-05 Indole derivative

Publications (2)

Publication Number Publication Date
NO920463D0 NO920463D0 (en) 1992-02-04
NO920463L true NO920463L (en) 1992-04-03

Family

ID=27306604

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92920463A NO920463L (en) 1990-06-05 1992-02-04 INDOLE-DERIVATIVES

Country Status (2)

Country Link
AU (1) AU644451B2 (en)
NO (1) NO920463L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3253077B2 (en) * 1991-07-05 2002-02-04 スミスクライン・ビーチャム・ファーマシューティチ・ソシエタ・ペル・アチオニ Hydroisoquinoline derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851417A (en) * 1988-05-26 1989-07-25 Rensselaer Polytechnic Institute 9-substituted 6H-pyrido[4,3-b]carbazoles

Also Published As

Publication number Publication date
AU644451B2 (en) 1993-12-09
AU7952691A (en) 1991-12-31
NO920463D0 (en) 1992-02-04

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