NO911049L - MATRIX WITH IMMUN MODULATIVE ACTIVITY. - Google Patents
MATRIX WITH IMMUN MODULATIVE ACTIVITY.Info
- Publication number
- NO911049L NO911049L NO91911049A NO911049A NO911049L NO 911049 L NO911049 L NO 911049L NO 91911049 A NO91911049 A NO 91911049A NO 911049 A NO911049 A NO 911049A NO 911049 L NO911049 L NO 911049L
- Authority
- NO
- Norway
- Prior art keywords
- matrix
- saponin
- adjuvants
- modulative
- immun
- Prior art date
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Iscom-matrise som Ikke er en lipidvesikkel omfattende minst ett llpid og minst en saponin uten tilsiktede antigenlske determinanter og eventuelt også adjuvants for anvendelse som et immunmodulerende middel, legemidler, vaksiner, klt som inneholder matrisen og nye saponlner, og en fremgangsmåte for fremstilling av nye saponlner, er beskrevet. Fremgangsmåten for fremstilling av matrisen kjennetegnet ved av minst en sterol blir oppløst i et oppløsningsmiddel eller en detergent, saponinen eller saponinene blir tilsatt, de andre adjuvantene og lipldene blir også eventuelt tilsatt, mens det organiske oppløsningsmidlet eller detergenten kan bli fjernet for eksempel ved dlalyse, ultraflltrerlng, gelfiltrerlng eller elektroforese, er også beskrevet. Sterolen og saponinen kan også bli oppløst i lipidene og/eller adjuvantene.Iscom matrix which is not a lipid vesicle comprising at least one lipid and at least one saponin without intended antigenic determinants and optionally also adjuvants for use as an immunomodulatory agent, drugs, vaccines, cloth containing the matrix and novel saponins, and a process for the preparation of novel saponlner, is described. The process for preparing the matrix characterized by at least one sterol is dissolved in a solvent or detergent, the saponin or saponins are added, the other adjuvants and lipids are also optionally added, while the organic solvent or detergent can be removed, for example, by dalysis. ultrafiltration, gel filtration or electrophoresis are also described. The sterol and saponin may also be dissolved in the lipids and / or adjuvants.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25157688A | 1988-09-30 | 1988-09-30 | |
| SE8901027A SE8901027D0 (en) | 1989-03-22 | 1989-03-22 | triterpenoids |
| SE8902780A SE8902780D0 (en) | 1989-08-16 | 1989-08-16 | CORNCERNING QA-MATRIX |
| PCT/SE1989/000528 WO1990003184A1 (en) | 1988-09-30 | 1989-09-28 | Matrix with immunomodulating activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO911049D0 NO911049D0 (en) | 1991-03-15 |
| NO911049L true NO911049L (en) | 1991-05-03 |
Family
ID=27484706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO91911049A NO911049L (en) | 1988-09-30 | 1991-03-15 | MATRIX WITH IMMUN MODULATIVE ACTIVITY. |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO911049L (en) |
-
1991
- 1991-03-15 NO NO91911049A patent/NO911049L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO911049D0 (en) | 1991-03-15 |
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