NO903851L - PROCEDURE FOR THE PREPARATION OF N-SUBSTITUTED-4-PYRIMIDAMINAMINES AND -PYRIMIDINE DIAMINES, AND THEIR USE AS MEDICINES. - Google Patents
PROCEDURE FOR THE PREPARATION OF N-SUBSTITUTED-4-PYRIMIDAMINAMINES AND -PYRIMIDINE DIAMINES, AND THEIR USE AS MEDICINES.Info
- Publication number
- NO903851L NO903851L NO90903851A NO903851A NO903851L NO 903851 L NO903851 L NO 903851L NO 90903851 A NO90903851 A NO 90903851A NO 903851 A NO903851 A NO 903851A NO 903851 L NO903851 L NO 903851L
- Authority
- NO
- Norway
- Prior art keywords
- loweralkyl
- hydrogen
- aryl
- pyrimidaminamines
- medicines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Abstract
This invention relates to N-heteroaryl-4-pyrimidinamines of the formula <CHEM> where R1 is hydrogen, loweralkyl, aryl, or arylloweralkyl; R2 and R3 are independently hydrogen or loweralkyl, or R2 and R3 taken together are aryl; R4 and R5 are independently hydrogen or loweralkyl, or R4 and R5 taken together are aryl; X is hydrogen, halogen, cyano, nitro, amino, loweralkyl, loweralkoxy, trifluoromethyl or <CHEM> where Y is hydrogen, halogen or loweralkyl; m is an integer of 1 to 3; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometrical and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as memory enhancing agents and as analgesic agents.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/402,415 US4983608A (en) | 1989-09-05 | 1989-09-05 | N-substituted-4-pyrimidinamines and pyrimidinediamines |
Publications (2)
Publication Number | Publication Date |
---|---|
NO903851D0 NO903851D0 (en) | 1990-09-04 |
NO903851L true NO903851L (en) | 1991-03-06 |
Family
ID=23591798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO90903851A NO903851L (en) | 1989-09-05 | 1990-09-04 | PROCEDURE FOR THE PREPARATION OF N-SUBSTITUTED-4-PYRIMIDAMINAMINES AND -PYRIMIDINE DIAMINES, AND THEIR USE AS MEDICINES. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4983608A (en) |
EP (1) | EP0417584B1 (en) |
JP (1) | JPH07116181B2 (en) |
KR (1) | KR0162641B1 (en) |
AT (1) | ATE163012T1 (en) |
AU (1) | AU626450B2 (en) |
CA (1) | CA2024572C (en) |
DE (1) | DE69032020T2 (en) |
DK (1) | DK0417584T3 (en) |
ES (1) | ES2112830T3 (en) |
FI (1) | FI904327A0 (en) |
GR (1) | GR3026318T3 (en) |
IE (1) | IE903213A1 (en) |
IL (1) | IL95568A (en) |
NO (1) | NO903851L (en) |
NZ (1) | NZ235145A (en) |
PT (1) | PT95202B (en) |
ZA (1) | ZA907033B (en) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5155098A (en) * | 1989-06-09 | 1992-10-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods employing them |
US5214038A (en) * | 1991-04-15 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof |
US5319096A (en) * | 1992-04-03 | 1994-06-07 | Hoechst-Roussel Pharmaceuticals Inc. | (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use |
US5459274A (en) * | 1994-05-13 | 1995-10-17 | Hoechst-Roussel Pharmaceuticals Inc. | Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines |
US5852028A (en) * | 1995-12-18 | 1998-12-22 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
WO1997009325A1 (en) * | 1995-09-01 | 1997-03-13 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
US5935966A (en) * | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
ZA989365B (en) * | 1997-10-15 | 1999-04-15 | Boehringer Mannheim Pharm Corp | Preparation for treating alzheimer's disease |
CA2321153A1 (en) | 1998-02-17 | 1999-08-19 | Timothy D. Cushing | Anti-viral pyrimidine derivatives |
ATE342892T1 (en) * | 1998-08-29 | 2006-11-15 | Astrazeneca Ab | PYRIMIDINE COMPOUNDS |
AU5438499A (en) | 1998-08-29 | 2000-03-21 | Astrazeneca Ab | Pyrimidine compounds |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
DE60039059D1 (en) * | 1999-10-07 | 2008-07-10 | Amgen Inc | TRIAZINE KINASE INHIBITORS |
US6410726B1 (en) | 2000-01-12 | 2002-06-25 | Tularik Inc. | Arylsulfonic acid salts of pyrimidine-based antiviral |
MXPA02007957A (en) * | 2000-02-17 | 2002-11-29 | Amgen Inc | Kinase inhibitors. |
GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004888D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
GB0021726D0 (en) * | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
GB0103926D0 (en) * | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
US7115617B2 (en) * | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
WO2003076434A1 (en) * | 2002-03-09 | 2003-09-18 | Astrazeneca Ab | 4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity |
GB0205693D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
GB0205688D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
GB0205690D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
BR0313059B8 (en) | 2002-07-29 | 2021-07-27 | Rigel Pharmaceuticals | compound, and, pharmaceutical composition |
EP2130541A3 (en) | 2002-07-29 | 2013-12-18 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
US7109337B2 (en) * | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
AU2003285614B2 (en) * | 2002-12-20 | 2009-05-14 | Pfizer Products, Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
GB0311274D0 (en) * | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
GB0311276D0 (en) * | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
RS53109B (en) | 2003-07-30 | 2014-06-30 | Rigel Pharmaceuticals Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
TW200528101A (en) * | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
US20060205945A1 (en) * | 2004-05-14 | 2006-09-14 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
CA2566477A1 (en) * | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
EP1758887A1 (en) * | 2004-05-14 | 2007-03-07 | Pfizer Products Incorporated | Pyrimidine derivatives for the treatment of abnormal cell growth |
MXPA06013164A (en) * | 2004-05-14 | 2007-02-13 | Pfizer Prod Inc | Pyrimidines derivatives for the treatment of abnormal cell growth. |
CA2578349A1 (en) * | 2004-09-01 | 2006-03-16 | Rigel Pharmaceuticals, Inc. | Synthesis of 2,4-pyrimidinediamine compounds |
ATE540035T1 (en) * | 2004-11-24 | 2012-01-15 | Rigel Pharmaceuticals Inc | SPIRO-2,4-PYRIMIDINEDIAMINE COMPOUNDS AND USES THEREOF |
BRPI0517426A (en) * | 2004-12-17 | 2008-10-07 | Astrazeneca Ab | compound, process for preparing same, pharmaceutical composition, use of a compound, and methods for producing an anti-cell proliferation effect, for producing a cdk2 inhibitory effect, and for treating a disease in a warm-blooded animal |
US20060270694A1 (en) * | 2005-05-03 | 2006-11-30 | Rigel Pharmaceuticals, Inc. | JAK kinase inhibitors and their uses |
AU2006274733B2 (en) * | 2005-07-30 | 2010-09-16 | Astrazeneca Ab | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders |
CA2623374A1 (en) * | 2005-09-30 | 2007-04-05 | Astrazeneca Ab | Imidazo [1,2-a] pyridine having anti-cell-proliferation activity |
TW200811169A (en) * | 2006-05-26 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
MX2009010536A (en) | 2007-04-13 | 2009-10-22 | Sanofi Aventis | A transition metal catalyzed synthesis of n-aminoindoles. |
US10239880B2 (en) * | 2015-04-17 | 2019-03-26 | Duquesne University Of The Holy Spirit | Cyclopenta[d]pyrimidines and substituted cyclopenta[d]pyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin inhibitors, and pyrrolopyrimidines as targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibition and antitumor agents |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4752610A (en) * | 1985-12-04 | 1988-06-21 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing properties |
US4792562A (en) | 1985-12-04 | 1988-12-20 | Hoechst-Roussel Pharmaceuticals, Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing activity |
EP0287982B1 (en) * | 1987-04-24 | 1994-12-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-(Pyridinyl)-1H-indol-1-amines, a process for their preparation and their use as medicaments |
US4806554A (en) * | 1988-01-11 | 1989-02-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Pyrazol and indazolpyridinamines |
US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
-
1989
- 1989-09-05 US US07/402,415 patent/US4983608A/en not_active Expired - Lifetime
-
1990
- 1990-09-01 ES ES90116826T patent/ES2112830T3/en not_active Expired - Lifetime
- 1990-09-01 DK DK90116826T patent/DK0417584T3/en active
- 1990-09-01 EP EP90116826A patent/EP0417584B1/en not_active Expired - Lifetime
- 1990-09-01 AT AT90116826T patent/ATE163012T1/en not_active IP Right Cessation
- 1990-09-01 DE DE69032020T patent/DE69032020T2/en not_active Expired - Lifetime
- 1990-09-03 IL IL9556890A patent/IL95568A/en unknown
- 1990-09-03 FI FI904327A patent/FI904327A0/en not_active IP Right Cessation
- 1990-09-03 NZ NZ235145A patent/NZ235145A/en unknown
- 1990-09-04 CA CA002024572A patent/CA2024572C/en not_active Expired - Lifetime
- 1990-09-04 AU AU62089/90A patent/AU626450B2/en not_active Ceased
- 1990-09-04 NO NO90903851A patent/NO903851L/en unknown
- 1990-09-04 ZA ZA907033A patent/ZA907033B/en unknown
- 1990-09-04 IE IE321390A patent/IE903213A1/en not_active IP Right Cessation
- 1990-09-04 PT PT95202A patent/PT95202B/en not_active IP Right Cessation
- 1990-09-04 JP JP2232639A patent/JPH07116181B2/en not_active Expired - Lifetime
- 1990-09-04 KR KR1019900013896A patent/KR0162641B1/en not_active IP Right Cessation
-
1998
- 1998-03-11 GR GR980400509T patent/GR3026318T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
JPH07116181B2 (en) | 1995-12-13 |
IE903213A1 (en) | 1991-03-13 |
DE69032020T2 (en) | 1998-07-09 |
PT95202B (en) | 1997-06-30 |
EP0417584B1 (en) | 1998-02-04 |
ES2112830T3 (en) | 1998-04-16 |
AU6208990A (en) | 1991-03-14 |
KR0162641B1 (en) | 1998-12-01 |
DK0417584T3 (en) | 1998-09-23 |
DE69032020D1 (en) | 1998-03-12 |
KR910006277A (en) | 1991-04-29 |
NZ235145A (en) | 1992-12-23 |
EP0417584A2 (en) | 1991-03-20 |
CA2024572A1 (en) | 1991-03-06 |
GR3026318T3 (en) | 1998-06-30 |
NO903851D0 (en) | 1990-09-04 |
CA2024572C (en) | 2000-09-26 |
ATE163012T1 (en) | 1998-02-15 |
US4983608A (en) | 1991-01-08 |
IL95568A0 (en) | 1991-06-30 |
IL95568A (en) | 1995-01-24 |
FI904327A0 (en) | 1990-09-03 |
AU626450B2 (en) | 1992-07-30 |
ZA907033B (en) | 1991-06-26 |
JPH0393784A (en) | 1991-04-18 |
PT95202A (en) | 1991-05-22 |
EP0417584A3 (en) | 1992-02-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO903851D0 (en) | PROCEDURE FOR THE PREPARATION OF N-SUBSTITUTED-4-PYRIMIDAMINAMINES AND -PYRIMIDINE DIAMINES, AND THEIR USE AS MEDICINES. | |
DK441187D0 (en) | ALFA-ALKYL-4-AMINO-3-QUINOLINMETHANOLS AND 1- (4-ARALKYLAMINO-3-QUINOLINYL) ALKANONS, THEIR PREPARATION AND USE | |
DK0637586T3 (en) | 2- (Piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl) -benzofuran-7-carbamate derivatives, their preparation and use | |
DK0402752T3 (en) | N-Heteroberl-purine-6-amines, process for their preparation and their use as drugs | |
HUT57773A (en) | Process for produicng n-(aminocarbonyl)-carbamates related to physostigmine, as well as pharmaceutical compositions comprising such compounds | |
NO903388L (en) | PROCEDURE FOR THE PREPARATION OF 1- (PYRIDINYLAMINO) -2-PYRROLIDINONES, AND USE AS MEDICINES. | |
NO920438D0 (en) | N- (ARYLOXYLKYL) HETEROARYL-8-AZABICYCLO (3.2.1.) OCTANES, INTERMEDIATES AND A PROCEDURE FOR PREPARING USE AS MEDICINES | |
NO903390L (en) | PROCEDURE FOR THE PREPARATION OF 2,3-DIHYDRO-1- (PYRIDINYLAMINO) INDOLES AND THEIR USE AS PHARMACEUTICALS. | |
ES2044043T3 (en) | PROCEDURE FOR PREPARING N-PIRIDINIL-9H-CARBAZOL-9-AMINAS. | |
NO894445L (en) | PROCEDURE FOR THE PREPARATION OF 1,2,3,4-TETRAHYDRO-1,9-ACRIDINE DIAMINES, AND THEIR USE AS MEDICINES. | |
BR0212932A (en) | Substituted alkylaminopyridazinone derivatives, process for their preparation, pharmaceutical composition containing them and their uses | |
NO913543L (en) | PROCEDURE FOR THE PREPARATION OF 3- (1H-INDAZOL-3-YL) -4-PYRIDINAMINES AND INTERMEDIATES, AND USE AS MEDICINES. | |
DK592589A (en) | CONDENSED HETEROCYCLIC DERIVATIVES OF 1,2,3,4-TETRAHYDROACRIDINE, THEIR PREPARATION AND USE | |
DK0401779T3 (en) | 4,5,5a, 6-Tetrahydro-3H-isoazolo (5,4,3-cl) acridine derivatives, a process for their preparation and their use as pharmaceuticals |