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Priority claimed from DK531986Aexternal-prioritypatent/DK531986D0/en
Application filed by Novo Industri AsfiledCriticalNovo Industri As
Publication of NO883021D0publicationCriticalpatent/NO883021D0/en
Publication of NO883021LpublicationCriticalpatent/NO883021L/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
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Peptides Or Proteins
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Abstract
Derivater av atriale natriuretislce peptider (ANP) hvori minst to av aainosyrerestene i ringstrukturen (posisjoner 7-23) er skiftet ut sed andre aainosyrerester og/eller son 1 den C-terminale ende (posisjon 28) er forlenget sed Pro, Trp. Phe eller H-MePhe eller en polypeptidrest sed én av de sistnevnte 4 aainosyrerester i den M-terainale ende bar forbedrede farmako-logiske egenskaper.'Derivatives of atrial natriuretislce peptides (ANP) in which at least two of the amino acid residues in the ring structure (positions 7-23) have been replaced with other amino acid residues and / or son 1 the C-terminal end (position 28) have been extended as Pro, Trp. Phe or H-MePhe or a polypeptide residue but one of the latter 4 amino acid residues at the M-terminal end had improved pharmacological properties.