NO880931L - BIODEGRADABLE SUPERPARAMAGNETIC MATERIALS FOR USE FOR CLINICAL APPLICATIONS. - Google Patents
BIODEGRADABLE SUPERPARAMAGNETIC MATERIALS FOR USE FOR CLINICAL APPLICATIONS.Info
- Publication number
- NO880931L NO880931L NO880931A NO880931A NO880931L NO 880931 L NO880931 L NO 880931L NO 880931 A NO880931 A NO 880931A NO 880931 A NO880931 A NO 880931A NO 880931 L NO880931 L NO 880931L
- Authority
- NO
- Norway
- Prior art keywords
- metal oxides
- superparamagnetic
- biological molecules
- tissues
- clinical applications
- Prior art date
Links
Abstract
In vivo bruk av biologisk nedbrytbare og metaboliser-bare supermagnetlserbare metalloksyder som MR kontrast-mldler avhenger av deres fremstilling, idet disse metalloksyder foreligger i form av superparamagnetiske partikkeldispersoider eller superparamagnetiske fluider der det omgivende medium er en fysiologisk aksepterbar bærer, hvorved partiklene kan være naken eller omgitt av et polymerbelegg hvortil biologiske molekyler kan forbindes.Når det gjelder belagte partikler kan de biologiske molekyler velges for målrettet å finne spesifikke organer eller vev.Biofordelingen av metalloksydene i målorganene eller -vevene resulterer i et mere detaljert billede av slike organer eller vev på grunn av metalloksydene, på grunn av deres superparamagnetiske egenskaper idet disse viser en grunnleggende virkning på hydrogenkjernen som er ansvarlig for MR billedet.In vivo use of biodegradable and metabolizable supermagnetizable metal oxides as MRI contrast agents depends on their preparation, these metal oxides being in the form of superparamagnetic particle dispersoids or superparamagnetic fluids where the surrounding medium is a physiologically acceptable carrier, whereby the particles may be surrounded by a polymeric coating to which biological molecules can be attached. In the case of coated particles, the biological molecules can be selected to purposefully find specific organs or tissues. The biodistribution of the metal oxides in the target organs or tissues results in a more detailed of the metal oxides, due to their superparamagnetic properties as they show a fundamental effect on the hydrogen core which is responsible for the MRI image.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/882,044 US4770183A (en) | 1986-07-03 | 1986-07-03 | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents |
| US07/067,586 US4827945A (en) | 1986-07-03 | 1987-06-26 | Biologically degradable superparamagnetic materials for use in clinical applications |
| PCT/US1987/001588 WO1988000060A1 (en) | 1986-07-03 | 1987-07-01 | Biodegradable superparamagnetic materials used in clinical applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO880931D0 NO880931D0 (en) | 1988-03-02 |
| NO880931L true NO880931L (en) | 1988-03-02 |
Family
ID=27371199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO880931A NO880931L (en) | 1986-07-03 | 1988-03-02 | BIODEGRADABLE SUPERPARAMAGNETIC MATERIALS FOR USE FOR CLINICAL APPLICATIONS. |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO880931L (en) |
-
1988
- 1988-03-02 NO NO880931A patent/NO880931L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO880931D0 (en) | 1988-03-02 |
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