NO865192L - FUSION PROTEINS WITH EUKARYOTIC BALL STANDARD. - Google Patents
FUSION PROTEINS WITH EUKARYOTIC BALL STANDARD.Info
- Publication number
- NO865192L NO865192L NO86865192A NO865192A NO865192L NO 865192 L NO865192 L NO 865192L NO 86865192 A NO86865192 A NO 86865192A NO 865192 A NO865192 A NO 865192A NO 865192 L NO865192 L NO 865192L
- Authority
- NO
- Norway
- Prior art keywords
- fusion proteins
- eukaryotic
- ball standard
- amino
- ball
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Abstract
Suitable as "ballast portion" for fusion proteins is a part of the amino-acid sequence of interleukin-2 (IL-2) which comprises considerably less than 100 amino acids. It is advantageous to start from a synthetic IL-2 gene which is divided by unique cleavage sites into six segments of which up to three can be linked in any desired sequence by the building block principle. Specific constructions allowing the solubility of the fusion protein to be varied are possible.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3545565 | 1985-12-21 | ||
DE19863636903 DE3636903A1 (en) | 1985-12-21 | 1986-10-30 | FUSION PROTEINS WITH EUKARYOTIC BALLASTES |
Publications (4)
Publication Number | Publication Date |
---|---|
NO865192D0 NO865192D0 (en) | 1986-12-19 |
NO865192L true NO865192L (en) | 1987-06-22 |
NO175003B NO175003B (en) | 1994-05-09 |
NO175003C NO175003C (en) | 1994-08-17 |
Family
ID=25839208
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO865192A NO175003C (en) | 1985-12-21 | 1986-12-19 | Fusion proteins with eukaryotic ballast fraction, vector containing a DNA encoding the fusion protein as well as E.coli cell containing the vector |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0229998B1 (en) |
JP (2) | JP2553058B2 (en) |
KR (1) | KR950000301B1 (en) |
AT (1) | ATE78296T1 (en) |
AU (1) | AU599943B2 (en) |
CA (1) | CA1339894C (en) |
DE (1) | DE3636903A1 (en) |
DK (1) | DK168823B1 (en) |
ES (1) | ES2033678T3 (en) |
FI (1) | FI93734C (en) |
GR (1) | GR3005985T3 (en) |
HU (1) | HU209747B (en) |
IE (1) | IE58935B1 (en) |
IL (1) | IL81018A (en) |
NO (1) | NO175003C (en) |
PT (1) | PT83973B (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3545568A1 (en) * | 1985-12-21 | 1987-07-16 | Hoechst Ag | GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE |
DE3844211A1 (en) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | NEW INSULINE DERIVATIVES, THE PROCESS FOR THEIR PRODUCTION, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM |
FR2643646B1 (en) * | 1989-02-27 | 1993-09-17 | Pasteur Institut | EXPRESSION OF NUCLEOTIDES SEQUENCES ENCODING FOR GAS VESICLES |
CU22222A1 (en) * | 1989-08-03 | 1995-01-31 | Cigb | PROCEDURE FOR THE EXPRESSION OF HETEROLOGICAL PROTEINS PRODUCED IN A FUSION FORM IN ESCHERICHIA COLI, ITS USE, EXPRESSION VECTORS AND RECOMBINANT STRAINS |
DE3942580A1 (en) * | 1989-12-22 | 1991-06-27 | Basf Ag | METHOD FOR PRODUCING HIRUDINE |
DE4105480A1 (en) * | 1991-02-21 | 1992-08-27 | Boehringer Mannheim Gmbh | IMPROVED ACTIVATION OF RECOMBINANT PROTEINS |
PT821006E (en) | 1996-07-26 | 2004-09-30 | Aventis Pharma Gmbh | INSULIN DERIVATIVES WITH ENHANCED ZINC LINK |
DE19825447A1 (en) | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | New insulin analogues with increased zinc formation |
DE102006031955A1 (en) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Process for the preparation of dibasic B chain end insulin analogs |
DE102006031962A1 (en) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidated insulin glargine |
PT2349324T (en) | 2008-10-17 | 2017-12-06 | Sanofi Aventis Deutschland | Combination of an insulin and a glp-1 agonist |
PL2498802T3 (en) | 2009-11-13 | 2015-06-30 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist, an insulin, and methionine |
EP2498801B1 (en) | 2009-11-13 | 2018-01-24 | Sanofi-Aventis Deutschland GmbH | PHARMACEUTICAL COMPOSITION COMPRISING desPro36Exendin-4(1-39)-Lys6-NH2 AND METHIONINE |
EP2611458B1 (en) | 2010-08-30 | 2016-09-21 | Sanofi-Aventis Deutschland GmbH | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
BR112014004726A2 (en) | 2011-08-29 | 2017-04-04 | Sanofi Aventis Deutschland | pharmaceutical combination for use in glycemic control in type 2 diabetes patients |
AR087744A1 (en) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF A NEURODEGENERATIVE DISEASE |
EP3229828B1 (en) | 2014-12-12 | 2023-04-05 | Sanofi-Aventis Deutschland GmbH | Insulin glargine/lixisenatide fixed ratio formulation |
TWI748945B (en) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | Treatment type 2 diabetes mellitus patients |
TW201705975A (en) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | Treatment of type 2 diabetes mellitus patients |
KR20200080748A (en) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | A Method for Purifying Proinsulin Using Anion Exchange Chromatography |
KR20200080747A (en) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | An Enzymatic Conversion Composition for Producing Insulin from Proinsulin and a Method for Producing Insulin from Proinsulin Using the Same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK108685A (en) * | 1984-03-19 | 1985-09-20 | Fujisawa Pharmaceutical Co | GROWTH FACTOR I |
EP0158198A1 (en) * | 1984-03-29 | 1985-10-16 | Takeda Chemical Industries, Ltd. | DNA and use thereof |
GB8412517D0 (en) * | 1984-05-16 | 1984-06-20 | Nagai K | Recombinant fusion proteins |
-
1986
- 1986-10-30 DE DE19863636903 patent/DE3636903A1/en not_active Withdrawn
- 1986-12-16 EP EP86117481A patent/EP0229998B1/en not_active Expired - Lifetime
- 1986-12-16 AT AT86117481T patent/ATE78296T1/en not_active IP Right Cessation
- 1986-12-16 ES ES198686117481T patent/ES2033678T3/en not_active Expired - Lifetime
- 1986-12-18 FI FI865187A patent/FI93734C/en not_active IP Right Cessation
- 1986-12-18 IL IL81018A patent/IL81018A/en not_active IP Right Cessation
- 1986-12-19 AU AU66760/86A patent/AU599943B2/en not_active Expired
- 1986-12-19 HU HU865354A patent/HU209747B/en unknown
- 1986-12-19 PT PT83973A patent/PT83973B/en unknown
- 1986-12-19 DK DK619186A patent/DK168823B1/en not_active IP Right Cessation
- 1986-12-19 NO NO865192A patent/NO175003C/en not_active IP Right Cessation
- 1986-12-19 CA CA000525858A patent/CA1339894C/en not_active Expired - Lifetime
- 1986-12-19 IE IE333486A patent/IE58935B1/en not_active IP Right Cessation
- 1986-12-20 KR KR1019860011010A patent/KR950000301B1/en not_active IP Right Cessation
- 1986-12-22 JP JP61306185A patent/JP2553058B2/en not_active Expired - Lifetime
-
1992
- 1992-10-15 GR GR920402187T patent/GR3005985T3/el unknown
-
1995
- 1995-10-11 JP JP7263310A patent/JP2774260B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPS62167799A (en) | 1987-07-24 |
KR870006187A (en) | 1987-07-09 |
FI93734C (en) | 1995-05-26 |
IL81018A0 (en) | 1987-03-31 |
JP2774260B2 (en) | 1998-07-09 |
AU6676086A (en) | 1987-06-25 |
AU599943B2 (en) | 1990-08-02 |
DK168823B1 (en) | 1994-06-20 |
NO175003B (en) | 1994-05-09 |
PT83973B (en) | 1989-07-31 |
NO865192D0 (en) | 1986-12-19 |
GR3005985T3 (en) | 1993-06-07 |
ATE78296T1 (en) | 1992-08-15 |
FI93734B (en) | 1995-02-15 |
EP0229998B1 (en) | 1992-07-15 |
DK619186A (en) | 1987-06-22 |
IE58935B1 (en) | 1993-12-01 |
CA1339894C (en) | 1998-06-02 |
DK619186D0 (en) | 1986-12-19 |
DE3636903A1 (en) | 1987-07-02 |
FI865187A (en) | 1987-06-22 |
FI865187A0 (en) | 1986-12-18 |
EP0229998A2 (en) | 1987-07-29 |
NO175003C (en) | 1994-08-17 |
HUT44614A (en) | 1988-03-28 |
EP0229998A3 (en) | 1988-08-03 |
IL81018A (en) | 1992-03-29 |
IE863334L (en) | 1987-06-21 |
HU209747B (en) | 1994-10-28 |
PT83973A (en) | 1987-01-01 |
JPH08187089A (en) | 1996-07-23 |
ES2033678T3 (en) | 1993-04-01 |
KR950000301B1 (en) | 1995-01-13 |
JP2553058B2 (en) | 1996-11-13 |
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FI863041A0 (en) | FUSIONSPROTEIN, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING. | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |