NO822706L - PROCEDURE FOR PREPARING NON-STEROID ANTI-INFLAMMATORY AND ANALGETIC ACTIVE COMPOUNDS - Google Patents

PROCEDURE FOR PREPARING NON-STEROID ANTI-INFLAMMATORY AND ANALGETIC ACTIVE COMPOUNDS

Info

Publication number
NO822706L
NO822706L NO822706A NO822706A NO822706L NO 822706 L NO822706 L NO 822706L NO 822706 A NO822706 A NO 822706A NO 822706 A NO822706 A NO 822706A NO 822706 L NO822706 L NO 822706L
Authority
NO
Norway
Prior art keywords
loweralkyl
pyrryl
substituted
hydrogen
inflammatory
Prior art date
Application number
NO822706A
Other languages
Norwegian (no)
Other versions
NO157697C (en
NO157697B (en
Inventor
James B Doherty
Michael N Chang
Conrad P Dorn
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO822706L publication Critical patent/NO822706L/en
Publication of NO157697B publication Critical patent/NO157697B/en
Publication of NO157697C publication Critical patent/NO157697C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Measurement Of Optical Distance (AREA)
  • Eye Examination Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Power Steering Mechanism (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Pyrrole compounds of the structural formula: <CHEM> or a pharmaceutically acceptable salt, ester or amide thereof have been prepared via hydrolysis of a precursor-ester after high temperature decarboxylation of from direct acidic decarboxylation of a precursor diacid. In the above formula, Ar is phenyl, substituted phenyl, pyridyl, pyrryl, substituted pyrryl, furyl or thienyl; R is, e.g., hydrogen, loweralkyl, lowercycloalkyl, lower(cycloalkyl-alkyl), loweralkenyl or halo-loweralkyl; R<1> is hydrogen or loweralkyl; R<2> is hydrogen, loweralkyl or halo; R<3> is, e.g., hydroxy, loweralkoxy, substituted loweralkoxy, amino, substituted amino, morpholinyl, glucosamino or heterocyclyl-oxy; X is (CH2)0-10-, -COCH2- or -CH2CO-; and Y is oxygen, sulfur, sulfinyl, sulfonyl, CH2 or H with the proviso that when Y is CH2-, Ar can only be pyrryl, and when Y is H, Ar is pyrryl and R is not present. The compounds are analgesic and anti-inflammatory agents of high activities out low ulcerogenic side effects.
NO822706A 1981-08-10 1982-08-09 ANALOGY PROCEDURE FOR THE PREPARATION OF NON-STEROIDAL COMPOUNDS WITH ANTI-INFLAMMATORY AND ANALGICAL EFFECT. NO157697C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29168881A 1981-08-10 1981-08-10

Publications (3)

Publication Number Publication Date
NO822706L true NO822706L (en) 1983-02-11
NO157697B NO157697B (en) 1988-01-25
NO157697C NO157697C (en) 1988-05-04

Family

ID=23121395

Family Applications (1)

Application Number Title Priority Date Filing Date
NO822706A NO157697C (en) 1981-08-10 1982-08-09 ANALOGY PROCEDURE FOR THE PREPARATION OF NON-STEROIDAL COMPOUNDS WITH ANTI-INFLAMMATORY AND ANALGICAL EFFECT.

Country Status (15)

Country Link
EP (1) EP0072013B1 (en)
JP (1) JPS5838255A (en)
AT (1) ATE19239T1 (en)
AU (1) AU556243B2 (en)
CA (1) CA1209989A (en)
DE (1) DE3270625D1 (en)
DK (1) DK356382A (en)
ES (1) ES8402818A1 (en)
FI (1) FI77022C (en)
GR (1) GR77260B (en)
IE (1) IE53667B1 (en)
NO (1) NO157697C (en)
NZ (1) NZ201468A (en)
PT (1) PT75381A (en)
ZA (1) ZA825746B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170244B (en) * 1983-11-14 1987-06-03 Poli Ind Chimica Spa PYRROL-3 CARBOXYLIC ACIDS WITH CENTRAL ANALGESIC ACTIVITY
DE10331496A1 (en) * 2003-07-01 2005-01-27 Bayer Cropscience Ag Process for preparing alkyl difluoroacetoacetates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3952012A (en) * 1970-01-26 1976-04-20 Mcneil Laboratories, Incorporated Aroyl-substituted pyrroles
US3998844A (en) * 1975-06-02 1976-12-27 Mcneil Laboratories, Incorporated Uncatalyzed aroylation of 1-alkylpyrrole-2-acetic acid derivatives
GB1592997A (en) * 1977-10-14 1981-07-15 Rolland Sa A Aroyl-pyrrole carboxylic acids and derivatives thereof
EP0006845B1 (en) * 1978-07-10 1982-02-03 McNeilab, Inc. Pharmaceutical composition comprising a 5-aroyl-1-c1-5 alkyl-pyrrole-2-acetic acid compound and acetaminophen or acetylsalicylic acid
EP0032048A1 (en) * 1980-01-08 1981-07-15 Beecham Group Plc Pyrroloylpyrrole derivatives, processes for their preparation and their use
NZ196700A (en) * 1980-04-18 1983-04-12 Smith & Nephew Ass Anti-inflammatory compositions containing 5-benzoyl-1-methylpyrrole-2-acetic acid derivatives

Also Published As

Publication number Publication date
ES514783A0 (en) 1984-02-01
IE821915L (en) 1983-02-10
DK356382A (en) 1983-02-11
ES8402818A1 (en) 1984-02-01
ATE19239T1 (en) 1986-05-15
EP0072013B1 (en) 1986-04-16
FI77022C (en) 1989-01-10
PT75381A (en) 1982-09-01
FI77022B (en) 1988-09-30
DE3270625D1 (en) 1986-05-22
JPS5838255A (en) 1983-03-05
GR77260B (en) 1984-09-11
FI822692L (en) 1983-02-11
EP0072013A1 (en) 1983-02-16
NO157697C (en) 1988-05-04
NO157697B (en) 1988-01-25
NZ201468A (en) 1986-02-21
AU556243B2 (en) 1986-10-30
FI822692A0 (en) 1982-08-02
AU8669082A (en) 1983-02-17
IE53667B1 (en) 1989-01-04
CA1209989A (en) 1986-08-19
ZA825746B (en) 1984-03-28

Similar Documents

Publication Publication Date Title
DE69013836D1 (en) Benzimidazole compounds and their application.
NO890074L (en) PROCEDURE FOR THE PREPARATION OF SUBSTITUTED PYRROL, PYRAZOL, AND TRIAZOLD DERIVATIVES.
AU589155B2 (en) Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido) azabicycloalkanes
PH25906A (en) Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)azabicycloalkanes
DK162644C (en) N, 3-DISUBSTITUTED 2-OXINDOL-1-CARBOXAMIDE DERIVATIVES AND 2-OXINDOL-1-CARBOXAMIDE COMPOUNDS FOR USE AS INTERMEDIATES IN THEIR PREPARATION
NO165799C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE 3-SUBSTITUTED 2-OXINDOL-1 CARBOXAMIDES AND INTERMEDIATES FOR USE IN THE PROGRESS.
NO175256C (en) Analogous Process for Preparing Therapeutically Active 4-Oxoquinoline-3-Carboxylic Acid Derivatives
GR3032220T3 (en) Use of 2-(N-(2-aminoethyl)amino)acetic acid derivatives for the treatment of diseases which are mediated by non-enzymatical glycosylation
PL289935A1 (en) Method of obtaining novel derivatives of 4h-pyrido-(1,2-a) pyrimidone-4
NO175310C (en) Analogous Process for Preparation of Therapeutically Active Pyrrolo (2,3-b) Indole Derivatives
NO822706L (en) PROCEDURE FOR PREPARING NON-STEROID ANTI-INFLAMMATORY AND ANALGETIC ACTIVE COMPOUNDS
FI894125A (en) An analogous method for preparing a therapeutically useful 3-piperidinyl indazole
AU637249B2 (en) 1-(pyridinylalkyl)-1h-indoles, indolines and related analogs
NZ215439A (en) Benzo(c) 1,5 naphthyridines and pharmaceutical compositions
CA2272665A1 (en) Method of treating glaucoma and ischemic retinopathy
NO832053L (en) PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 5-AROYL-6-ALKYLTHIO-1,2-DIHYDRO-3H-PYRROLO- (1,2-A) -PYRROL-1-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF